Protective mechanism of Paeonol on central nervous system

Abstract

Cerebrovascular diseases involve neuronal damage, resulting in degenerative neuropathy and posing a serious threat to human health. The discovery of effective drug components from natural plants and the study of their mechanism are a research idea different from chemical synthetic medicines. Paeonol is the main active component of traditional Chinese medicine Paeonia lactiflora Pall. It widely exists in many medicinal plants and has pharmacological effects such as anti‐atherosclerosis, antiplatelet aggregation, anti‐oxidation, and anti‐inflammatory, which keeps generally used in the treatment of cardiovascular and cerebrovascular diseases. Based on the therapeutic effects of Paeonol for cardiovascular and cerebrovascular diseases, this article reviewed the pharmacological effects of Paeonol in Alzheimer's disease, Parkinson's disease, stroke, epilepsy, diabetes encephalopathy, and other neurological diseases, providing a reference for the research of the mechanism of Paeonol in central nervous system diseases.

Design, synthesis, and evaluation of the novel ozagrel–paeonol codrug with antiplatelet aggregation activities as a potent anti-stroke therapeutic agent

“…Paeonol (2′-hydroxy-4′-methoxyacetophenone), a bioactive ingredient in the Cortex Moutan of traditional Chinese medicine, has been found to inhibit antiplatelet aggregation and anti-inflammatory activity and suppress oxidative stress ( Zhang et al, 2019 ). Numerous studies have demonstrated that paeonol can protect the brain from damage and reduce the area of cerebral infarction caused by ischemic stroke ( Zhao et al, 2018 ; Wu et al, 2023 ). Nevertheless, paeonol has poor water solubility and a high metabolic rate, both of which impede its use in clinical applications ( Zhang M. et al, 2021 ).…”