Protective Mechanisms of Quercetin in Various Lung-induced Injuries

Rizky, Wahyu Choirur; Jihwaprani, Muhammad Candragupta; Mushtaq, Mazhar

doi:10.54647/cm32844

Cited by 2 publications

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“…QUE is the most studied phytochemical and an important flavonoid for research [4]. Specifically, a growing body of well-documented evidence suggests numerous therapeutic and prophylactic roles of QUE in various diseases (e.g., neurodegenerative, infectious, and cardiovascular) and other bioactive processes (e.g., antimicrobial, antiviral, antioxidants, and antiaging) [5,6]. Most recently, numerous clinical trials have been conducted to examine the roles of QUE as an adjunct therapy for the coronavirus disease 2019 (COVID-19) [7].…”

Section: Introductionmentioning

confidence: 99%

Pharmacokinetics of Quercetin

Candragupta Jihwaprani,

Choirur Rizky,

Mushtaq

2023

Quercetin - Effects on Human Health [Working Title]

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Quercetin (QUE) is a primary polyphenol in the flavonoid family. It is categorized as one of the six subclasses of flavonoid compounds. As an abundant form of flavonoid molecules, quercetins are ubiquitously distributed in various dietary plants, including apples, berries, onions, bananas, tomatoes, and grapes. Furthermore, it is affordably marketed in the form of dietary supplement tablets. QUE is relatively lipophilic with low solubility in the water. Withal, QUE glucoside is more water soluble than the aglycone, and its absorption is limited to sodium-dependent glucose transporter-1 (SGLT-1); however, glucose transporter-2 (GLUT-2)-dependent absorption is also a significant contributor. Following absorption, QUE undergoes extensive metabolism in the liver, generating numerous metabolites. Data on the bioavailability of QUE differ substantially depending on the methods used for measuring QUE level. Pharmacokinetic interactions of QUE and its metabolites on cytochrome P450 enzymes have been studied extensively, but the results among the studies were inconsistent, such as weak inhibition toward CYP3A4 and no inhibition of CYP2D6 activity. Additionally, inhibition affects ATP- (adenosine triphosphate) binding cassette (ABC). Based on the pharmacokinetics profile, QUE has variable bioavailability based on the polymorphism of intestinal enzymes and transporters.

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Section: Introductionmentioning

confidence: 99%

Pharmacokinetics of Quercetin

Candragupta Jihwaprani,

Choirur Rizky,

Mushtaq

2023

Quercetin - Effects on Human Health [Working Title]

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Protective mechanism of quercetin and its derivatives in viral-induced respiratory illnesses

2022

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Globally, acute respiratory illnesses are the most commonly manifesting illness in all age group. The disease mostly affects the upper respiratory tract (URT) and is self-limiting. However, a small percentage progresses to lower respiratory tract infections (LRTI). The most important causative agents of severe LRTIs are bacteria and viruses. Various viruses can cause respiratory tract infections, being the most essential belonging to the Orthomyxoviridae, Paramyxoviridae, Picornaviridae, coronaviruses, and adenoviruses. Quercetin is classified as a flavonoid compound and was previously known to have antiviral, antibacterial, antioxidant, and anti-inflammatory activities. Some preclinical studies highlight quercetin could also interfere with coronavirus infection and modulate the release of pro-inflammatory cytokines. Since there is no comprehensive compilation addressing the antiviral activities of quercetin and its derivatives, this narrative review provides a summary of the preclinical evidence of their antiviral activities on respiratory illnesses induced by viruses other than coronaviruses. The literature research was performed in PubMed, Scopus, and Google Scholar. The results explain that quercetin has a wide range of actions in viral-induced respiratory illnesses including, but not limited to suppressing pro-inflammatory cytokines and chemokines, promoting antioxidant-related genes expression, blocking viral entry and replication, accelerating viral clearance, reducing the accumulation of alveolar macrophages, and reducing goblet cells marker and mucin gene expression.

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Protective Mechanisms of Quercetin in Various Lung-induced Injuries

Cited by 2 publications

References 0 publications

Pharmacokinetics of Quercetin

Pharmacokinetics of Quercetin

Protective mechanism of quercetin and its derivatives in viral-induced respiratory illnesses

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