Protective Mechanisms of SGLTi in Ischemic Heart Disease

Liao, Lei; Wang, Tong; Zhang, Lu; Wei, Yan; Fan, Xinrong

doi:10.1007/s12265-024-10513-x

J. of Cardiovasc. Trans. Res.

2024

DOI: 10.1007/s12265-024-10513-x

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Protective Mechanisms of SGLTi in Ischemic Heart Disease

Lei Liao,

Tong Wang,

Lu Zhang

et al.

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2024

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Cited by 1 publication

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The Off-Target Cardioprotective Mechanisms of Sodium–Glucose Cotransporter 2 Inhibitors: An Overview

Ionică,

Lința,

Bătrîn

et al. 2024

IJMS

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Sodium–glucose cotransporter 2 inhibitors (SGLT2i), a novel class of glucose-lowering drugs, have revolutionized the management of heart failure with reduced and preserved ejection fraction, regardless of the presence of diabetes, and are currently incorporated in the heart failure guidelines. While these drugs have consistently demonstrated their ability to decrease heart failure hospitalizations in several landmark clinical trials, their cardioprotective effects are far from having been completely elucidated. In the past decade, a growing body of experimental research has sought to address the molecular and cellular mechanisms of SGLT2i in order to provide a better understanding of the off-target acute and chronic cardiac benefits, beyond the on-target renal effect responsible for blood glucose reduction. The present narrative review addresses the direct cardioprotective effects of SGLT2i, delving into the off-target mechanisms of the drugs currently approved for heart failure therapy, and provides insights into future perspectives.

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The Off-Target Cardioprotective Mechanisms of Sodium–Glucose Cotransporter 2 Inhibitors: An Overview

Ionică,

Lința,

Bătrîn

et al. 2024

IJMS

View full text Add to dashboard Cite

show abstract

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Protective Mechanisms of SGLTi in Ischemic Heart Disease

Cited by 1 publication

References 134 publications

The Off-Target Cardioprotective Mechanisms of Sodium–Glucose Cotransporter 2 Inhibitors: An Overview

The Off-Target Cardioprotective Mechanisms of Sodium–Glucose Cotransporter 2 Inhibitors: An Overview

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