Protective of Ethanolic Extract of Saussurea Lappa Against Paracetamol-Induced Hepatic and Renal Damage in Male Rabbits

Abstract

Objective: The objective of our study is to investigate the effect of the ethanolic extract of Saussurea lappa against paracetamol-induced hepatorenal toxicity in male rabbits.
 Methods: Eighteen male rabbits were used for this study and were divided into three groups of six rabbits each. Group 1: Rabbits were the normal (negative control), Group 2: (Positive control) Rabbits were administered paracetamol at dose 300 mg/kg body weight (B.W) for 14 day, and Group 3: Rabbits received paracetamol at dose 300 mg/kg B.W then treated with ethanolic extract of S. lappa at dose 300 mg/kg B.W for 14 day.
 Results: The obtained results showed a significant decrease (p≤0.05) in B.W, red blood cells count, white blood cells count, neutrophil, total protein, and albumin with significant (p≤0.05) increase in lymphocyte, alanine aminotransferase, aspartate aminotransferase, creatinine, urea, and malondialdehyde in rabbits of positive control group, histological studies showed many pathological changes in liver and kidney when compared with negative control group. The oral administration of the ethanolic extract of S. lappa significantly protected the hepatic and kidney cells from damage, the hematological and biochemical parameters were also almost normal in extract treated rabbits compared to the control group.
 Conclusion: Our study indicates that the roots of S. lappa act as antioxidant substance and have hepato and renoprotective effect against toxicity induced by paracetamol.

Saussurea lappa Ethanolic Extract Attenuates Triamcinolone Acetonide-Induced Pulmonary and Splenic Tissue Damage in Rats via Modulation of Oxidative Stress, Inflammation, and Apoptosis

“…Initially, the erythrogram and leukogram components were not significantly altered in the S. lappa ethanolic-extract-treated group except for notable leukocytosis and lymphocytosis. A comparable hemogram was previously reported following S. lappa oral administration in rats [56] and rabbits [57]. The increment of lymphocyte count is usually associated with the enhancement of murine immunological function [58].…”

Evaluation of the hepatoprotective role of ethanolic Saussurea lappa root extract in female rats experimentally exposed to propylthiouracil

“…In contrast, liver tissue of GIII and GIV rats improved greatly, as shown by current histological examination compared to GII. The results of our current study agree with [30]. In a recent study, it was found that the extract of the S.lappa root can protect the liver from the toxic effect of CCL 4 [31].…”

“…These results are in agreement with [35,36]. This might be because phytochemical components including flavonoids, and chlorogenic acid function as antioxidants, reducing PTU toxicity by decreasing free radical-induced lipid peroxidation [30,37].…”

Influence of Costus Roots Extract on Productive Performance, Physiological Responses and Bacterial Count in Weaning Rabbits

“…The same results obtained by Saad et al, (2018) who reported that oral administration of an aqueous extract of Indian costus significantly increased body weights when compared to the control group, also, Kadhem (2019) showed a significant increase (P≤0.05) in final LBW and BWG of rabbits treated with the ethanolic extract of Saussurea lappa compared to the control group, through its contents which were flavonoids, proteins, and carbohydrates, which are necessary for growth, body repair, and maintenance.…”