Protective potential of misoprostol against kidney alteration via alleviating oxidative stress in rat following exposure to paclitaxel

Aktaş, İbrahim; Yahyazadeh, Ahmad

doi:10.1016/j.tice.2022.101966

Cited by 8 publications

(5 citation statements)

References 38 publications

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Section: Discussionmentioning

confidence: 85%

“…[22] It was also reported that SOD activity, which decreased with CP application, increased with CUR application. [42] MDA causes serious oxidative stress in the brain with the phagocytosis of ROS and macrophages produced as a by-product of the metabolic process. [14] Overproduction of NO, considered a proinflammatory mediator, directly causes DNA damage, mitochondrial membrane damage, and apoptosis.…”

Section: Discussionmentioning

confidence: 99%

“…[ 4,20,40,41 ] In another study, CP application also caused a decrease in SOD activity. [ 42 ] A significant increase in SOD, CAT, and GPx activities, and GSH levels after treatment in groups 5 (CP + 200 CUR–PP) and 6 (CP + 300 CUR–PP) may reveal the regulatory effects of the CUR–PP combination against oxidative damage, thus preventing the moderate decrease in the activities of antioxidant enzymes in rats. In line with the data of this study, other studies have shown that a CUR–PP combination prevents oxidative stress by restoring antioxidant enzymes and protecting against peroxynitrite.…”

Section: Discussionmentioning

confidence: 99%

“…[ 22 ] It was also reported that SOD activity, which decreased with CP application, increased with CUR application. [ 42 ]…”

Section: Discussionmentioning

confidence: 99%

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Investigation of the effects of curcumin and piperine on cyclophosphamide‐induced brain injury in rats

Aygörmez,

Maraşli

2024

J Biochem & Molecular Tox

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Cyclophosphamide (CP) is an antineoplastic drug widely used in chemotherapy. Curcumin (CUR) and piperine (PP) show a protective effect on neurodegenerative and neurological diseases. This research was designed to measure several biochemical parameters in the brain tissue of CP‐applied rats to investigate the impact of combined CUR–PP administration. The study evaluated six groups of eight rats: Group 1 was the control; Groups 2 and 3 were administered 200 or 300 mg/kg CUR‐PP via oral gavage; Group 4 received only 200 mg/kg CP on day 1; Groups 5 and 6 received CP + CUR‐PP for 7 days. Data from all parameters indicated that CP caused brain damage. Phosphorylated TAU (pTAU), amyloid‐beta peptide 1–42 (Aβ1–42), glutamate (GLU), and gamma amino butyric acid (GABA) parameters were the same in Groups 4, 5, and 6. On the other hand, 8‐hydroxy‐2‐deoxyguanosine (8‐OHdG), nitric oxide (NO), interleukin‐6 (IL‐6), nuclear factor kappa beta (NF‐kβ), malondialdehyde (MDA), and tumor necrosis factor‐alpha (TNF‐α) levels in the CP + CUR‐PP groups were lower than those in the CP group (p < 0.05). However, superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GPx), and reduced glutathione (GSH) parameters were higher in the CP + CUR‐PP groups compared to the CP group (p < 0.05). It is thought that the similarity of Groups 5 and 6 with Group 4 in Aβ1–42, pTAU, GLU, and GABA parameters hinder the determination of treatment protection however, they might have a therapeutic effect if the applied dose or study duration were changed. This study attempted to evaluate the effects of a CUR–PP combination on CP‐induced brain damage in rats by measuring biochemical parameters and performing histopathological examinations. Based on the findings, this CUR–PP combination could be considered an alternative medicine option in cases with conditions similar to those evaluated in this study.

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Section: Discussionmentioning

confidence: 85%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

“…[ 22 ] It was also reported that SOD activity, which decreased with CP application, increased with CUR application. [ 42 ]…”

Section: Discussionmentioning

confidence: 99%

See 2 more Smart Citations

Investigation of the effects of curcumin and piperine on cyclophosphamide‐induced brain injury in rats

Aygörmez,

Maraşli

2024

J Biochem & Molecular Tox

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“…Thus, it shows its therapeutic effect by preventing the proliferation of tumor cells. [ 11 ] Appropriate doses for treatment with PTX are generally high, and these doses cause toxic effects. [ 12 ] PTX caused pathological changes in testicular tissue and decreased spermatozoa activity.…”

Section: Introductionmentioning

confidence: 99%

Naringin protects against paclitaxel‐induced toxicity in rat testicular tissues by regulating genes in pro‐inflammatory cytokines, oxidative stress, apoptosis, and JNK/MAPK signaling pathways

Kankılıç,

Küçükler,

Gür

et al. 2024

J Biochem & Molecular Tox

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Paclitaxel (PTX), which is actively used in the treatment of many types of cancer, has a toxic effect by causing increased oxidative stress in testicular tissues. Naringin (NRG) is a natural flavonoid found in plants, and its antioxidant properties are at the forefront. This study aims to investigate the protective feature of NRG in PTX‐induced testicular toxicity.Thirty‐five male Sprague rats were divided into five groups: control, NRG, PTX, PTX + NRG50, and PTX + NRG100. Rats were administered PTX (2 mg/kg, BW) intraperitoneally once daily for the first 5 days. Then, between the 6th and 14th days, NRG (50 and 100 mg/kg) was administered orally once a day.NRG reduced PTX‐induced lipid peroxidation and increased testicular tissue antioxidant capacity (superoxide dismutase, catalase, glutathione peroxidase, and glutathione). While NRG reduces the mRNA expression levels of nuclear factor kappa B, tumor necrosis factor‐alpha, interleukin‐1 beta, cyclooxygenase‐2, interleukin‐6, inducible‐nitric oxide synthase, mitogen‐activated protein kinase 14 (MAPK)14, MAPK15, c‐Jun N‐terminal kinase, P53, Apaf1, Caspase3, Caspase6, Caspase9, and Bax in testicular tissues; it caused an increase in Nrf2, HO‐1, NQO1 and Bcl‐2 levels. NRG also improved the structural and functional integrity of testicular tissue disrupted by PTX. PTX‐induced sperm damage was alleviated by NRG.NRG showed a protective effect by alleviating the PTX‐induced testicular toxicity by increasing oxidative stress, inflammation, apoptosis, and autophagy.

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Promising the potential of β-caryophyllene on mercury chloride–induced alteration in cerebellum and spinal cord of young Wistar albino rats

Yahyazadeh,

Gur

2024

Naunyn-Schmiedeberg's Arch Pharmacol

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Mercury chloride (ME) is a chemical pollutant commonly found in the environment, which can contribute to undesirable health consequence worldwide. The current study investigated the detrimental impact of ME on the cerebellum and spinal cord tissues in 6–8-week-old female rats. We also evaluated the neuroprotective efficacy of β-caryophyllene (BC) against spinal and cerebellar changes caused by ME. Thirty-five young Wistar albino rats were randomly chosen and assigned into five groups: control (CO), olive oil (OI), ME, BC, ME + BC. All samples were analysed by means of unbiased stereological, biochemical, immunohistochemical, and histopathological methods. Our biochemical findings showed that SOD level was significantly increased in the ME group compared to the CO group (p < 0.05). We additionally detected a statistically significant decrease in the number of cerebellar Purkinje cells and granular cells, as well as spinal motor neuron in the ME group compared to the CO group (p < 0.05). In the ME + BC group, the number of Purkinje cells, granular cells, and spinal motor neurons was significantly higher compared to the ME group (p < 0.05). Decreased SOD activity in the ME + BC group was also detected than the ME group (p < 0.05). Immunohistochemical (the tumour necrosis factor-alpha (TNF-α)) and histopathological examinations also exhibited crucial information in each of the group. Taken together, ME exposure was associated with neurotoxicity in the cerebellum and spinal cord tissues. BC treatment also mitigated ME-induced neurological alteration, which may imply its potential therapeutic benefits.

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Protective potential of misoprostol against kidney alteration via alleviating oxidative stress in rat following exposure to paclitaxel

Cited by 8 publications

References 38 publications

Investigation of the effects of curcumin and piperine on cyclophosphamide‐induced brain injury in rats

Investigation of the effects of curcumin and piperine on cyclophosphamide‐induced brain injury in rats

Naringin protects against paclitaxel‐induced toxicity in rat testicular tissues by regulating genes in pro‐inflammatory cytokines, oxidative stress, apoptosis, and JNK/MAPK signaling pathways

Promising the potential of β-caryophyllene on mercury chloride–induced alteration in cerebellum and spinal cord of young Wistar albino rats

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