Protective potential of pterostilbene against cyclophosphamide-induced nephrotoxicity and cystitis in rats

Keri̇moğlu, Gökçen; Arıcı, Tuğba; Bıyık, Ayşe Firuze; Kulaber, Ali; Alemdar, Nihal Türkmen; Demir, Selim; Aliyazıcıoğlu, Yüksel; Yenilmez, Engin

doi:10.1007/s11255-023-03735-6

Cited by 2 publications

(4 citation statements)

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“…Acrolein is considered a toxic metabolite and shows potential and deleterious toxic effects leading to multiorgan toxicity, including nephrotoxicity . This is because when CPM is administered at the therapeutic dose, it exhibits anticancer and organ damage . This property of CPM sometimes limits its clinical use and, when used, significantly hampers the clinical outcome and quality of life of patients.…”

Section: Introductionmentioning

confidence: 99%

“…This property of CPM sometimes limits its clinical use and, when used, significantly hampers the clinical outcome and quality of life of patients. Among various toxicity manifested by CPM, renal toxicity is considered the most deleterious and potential one . Since the kidney is one of the vital organs, any minor damage to this reflects altered homeostasis and hampers physiological function.…”

Section: Introductionmentioning

confidence: 99%

“… 2 This is because when CPM is administered at the therapeutic dose, it exhibits anticancer and organ damage. 3 This property of CPM sometimes limits its clinical use and, when used, significantly hampers the clinical outcome and quality of life of patients. Among various toxicity manifested by CPM, renal toxicity is considered the most deleterious and potential one.…”

Section: Introductionmentioning

confidence: 99%

“…Among various toxicity manifested by CPM, renal toxicity is considered the most deleterious and potential one. 3 Since the kidney is one of the vital organs, any minor damage to this reflects altered homeostasis and hampers physiological function.…”

Section: Introductionmentioning

confidence: 99%

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Nephroprotective Effect of Bergapten Against Cyclophosphamide-Mediated Renal Stress, Inflammation, and Fibrosis in Wistar Rats: Probable Role of NF-kB and TGF-β1 Signaling Molecules

Mohsin,

Akhtar,

Alkahtani

et al. 2024

ACS Omega

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Cyclophosphamide (CPM) is a well-established antineoplastic drug with marked clinical outcomes in various types of cancers. Despite being a promising drug, its use is associated with significant renal toxicity and often limits its use, leading to compromised clinical outcomes. Therefore, this study explored the renal protective effect of bergapten (BGP), a natural bioactive compound that showed marked antioxidant, anti-inflammatory, anticancer, and neuroprotective effects. Till now, BGP has not been studied for its renal protective effect in an in vivo model. Animals were divided into control, toxic, BGP-3, BGP-10, and BGP Per se. The control group was treated with normal saline for 2 weeks. To the toxic group, CPM 200 mg/kg was given on day 7 as i.p. To BGP-3, 10, and Per se, BGP-3 and 10 mg/kg, ip was given 2 weeks with a single shot of CPM 200 day 7. To the Per se group, only BGP 10 mg/kg, ip was given from day 1 to day 14. After 14 days, animals were sacrificed, and kidneys were removed and studied for the markers of oxidative stress, inflammation, renal injury, renal fibrosis, and renal damage using biochemical, histopathological, and immunohistochemical studies. We found that BGP-10 effectively reversed the damage toward normal, whereas BGP-3 failed to exhibit a significant renal protective effect. We conclude that bergapten could be a potential renal protective drug, and hence, more detailed cellular molecular-based studies are needed to bring this drug from the bench to the bedside.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%