Protective Role of Alpha Lipoic Acid against the Deleterious Effects of both Natural and Artificial Sweetener (Sucrose and Aspartame) in Albino Rats

Gafar, Hamdy B.; Taha, Nabil M.; Noeman, Saad N.; Mandour, Abdelwahab; Lepda, Mohamed

doi:10.5455/ajvs.226301

Cited by 3 publications

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“…These outcomes agreed with who announced that the administration of ASP had a fundamentally expanded level of cholesterol and triglycerides in rats [37,54].…”

Section: Effect On Glucose Liver Kidney and Lipid Function Testssupporting

confidence: 72%

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Ameliorative Role of Silymarin Against Aspartame–induced Biochemical Changes, Oxidative Stress, Inflammatory Effect and Genotoxicity in Male Albino Rats

Elballat

Abas

2020

Int J Curr Pharm Sci

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Objective: Aspartame (ASP) is one of the most common artificial sweeteners. It has been recorded to be safe by World Health Organization. However, numerous publications have concluded that ASP is a genotoxic and carcinogenic sweetener. Methods: The current study aims to examine the effect of ASP consumption (250 mg/kg body weight/day for 90 d) on some biochemical parameters, oxidative/antioxidative status in different tissues, Tumor Necrosis Factor-α (TNF-α), chromosomal aberration (CA) frequency and mitotic index (MI) percentage in addition to the possible ameliorative role of silymarin (50 mg/kg body weight/day for 90 d) against ASP-induced toxicity in male albino rats. Results: The present results have confirmed that ASP is able to induce significant increase in the blood glucose level, liver, kidney and lipid function tests, Malondialdehyde (MDA) level, serum TNF-α level, frequency of CA and MI%. Meanwhile, Glutathione reduced level (GSH), Glutathione–S-transferase (GST) and catalase activity (CAT) were decreased by ASPadministration. Recovery group showed slight enhancement in all parameters but remained significant as compared to the control group. Co-administration of ASP with silymarin showed greater improvement than the recovery group. Conclusion: Silymarin have an ameliorative role against biochemical oxidative stress, inflammatory changes in blood and different tissues, chromosomal aberrations and MI% induced by ASP administration.

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“…These outcomes agreed with who announced that the administration of ASP had a fundamentally expanded level of cholesterol and triglycerides in rats [37,54].…”

Section: Effect On Glucose Liver Kidney and Lipid Function Testssupporting

confidence: 72%

“…Previous studies indicated a critical diminishing of level of serum albumin in contrast with the untreated group. Oral dosing of ASP had no impact on total serum protein at 45 d, but it essentially diminished at 90 d of administration [54].…”

Section: Effect On Glucose Liver Kidney and Lipid Function Testsmentioning

confidence: 90%

Ameliorative Role of Silymarin Against Aspartame–induced Biochemical Changes, Oxidative Stress, Inflammatory Effect and Genotoxicity in Male Albino Rats

Elballat

Abas

2020

Int J Curr Pharm Sci

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“…The shielding effects of LA on testis and cauda epididymis against oxidative damage-induced Sertoli-and Leydig cell toxicity, reduced sperm motility, reduced sperm DNA damage, disrupted testicular and caudaepididymal structural integrity via enhancement of superoxide dismutase (SOD), and catalase (CAT) and restoration of glutathione system has been demonstrated [115][116][117][122][123][124] . The positive role of GSH (reduced glutathione) GSH synthesis enzymes have been reported.…”

Section: Fig 3: Chemical Structure Of Alpha Lipoic Acidmentioning

confidence: 99%

Untitled

2023

IJPSR

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Male reproduction is controlled and coordinated by endocrine factors and therefore, even minute changes can able to interfere with the male fertility. Accumulation of data have shown that the humans are exposed to chemicals that can able to interfere with endocrine factors. Interestingly, published reports have shown that the continuous exposure to such chemicals occurs mainly due to their wide usage in a variety of personal care and daily products such as plastics, food, water, fertilizers, textiles, shampoos, toys and pharma drugs etc. In view of ongoing interest in exposure of humans to such agents and compromised male fertility, there is a major concern and attention towards the endocrine disrupting chemicals among the public, endocrinologists, andrologists and scientific community. These chemicals interfere with the endocrine functions via mimicking their structure, blocking the hormone receptor and/or function of genes and proteins that facilitate normal spermatogenesis and testosterone biosynthesis. The present review provides an overview of endocrine disrupting chemicals on male reproductive health with a special focus on thyroid hormone disrupting chemicals. The present review was categorized into three broad aspects. The first aspect deals with the endocrine disruption of spermatogenesis and steroidogenesis. The second aspect deals with the effect of thyroid hormone disrupting chemicals on testicular functions and the final aspect deals with the role of α-lipoic acid induced amelioration of male fertility efficacy against the thyroid hormone disrupting chemicals. Finally the challenges and gaps were highlighted.

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α-lipoic acid inhibits oxidative stress in testis and attenuates testicular toxicity in rats exposed to carbimazole during embryonic period

et al. 2017

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Protective Role of Alpha Lipoic Acid against the Deleterious Effects of both Natural and Artificial Sweetener (Sucrose and Aspartame) in Albino Rats

Cited by 3 publications

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Ameliorative Role of Silymarin Against Aspartame–induced Biochemical Changes, Oxidative Stress, Inflammatory Effect and Genotoxicity in Male Albino Rats

Ameliorative Role of Silymarin Against Aspartame–induced Biochemical Changes, Oxidative Stress, Inflammatory Effect and Genotoxicity in Male Albino Rats

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α-lipoic acid inhibits oxidative stress in testis and attenuates testicular toxicity in rats exposed to carbimazole during embryonic period

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