Protective role of aqueous rosemary extract against hepatorenal toxicity of paracetamol in male rats

Hozayen, Walaa G.; Soliman, Hanan A.; Desouky, Ekram M.

doi:10.1097/01.mjx.0000446935.02536.1b

Cited by 13 publications

(18 citation statements)

References 44 publications

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“…These observations agreed with who viewed that the histopathological profile of the rat kidney treated with ASP showed congestion in the sclerotic cortical blood vessels with swelling in the coating epithelial cells of the tubules [93].…”

Section: Histopathological Examinationsupporting

confidence: 91%

Ameliorative Role of Silymarin Against Aspartame–induced Biochemical Changes, Oxidative Stress, Inflammatory Effect and Genotoxicity in Male Albino Rats

Elballat

Abas

2020

Int J Curr Pharm Sci

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Objective: Aspartame (ASP) is one of the most common artificial sweeteners. It has been recorded to be safe by World Health Organization. However, numerous publications have concluded that ASP is a genotoxic and carcinogenic sweetener. Methods: The current study aims to examine the effect of ASP consumption (250 mg/kg body weight/day for 90 d) on some biochemical parameters, oxidative/antioxidative status in different tissues, Tumor Necrosis Factor-α (TNF-α), chromosomal aberration (CA) frequency and mitotic index (MI) percentage in addition to the possible ameliorative role of silymarin (50 mg/kg body weight/day for 90 d) against ASP-induced toxicity in male albino rats. Results: The present results have confirmed that ASP is able to induce significant increase in the blood glucose level, liver, kidney and lipid function tests, Malondialdehyde (MDA) level, serum TNF-α level, frequency of CA and MI%. Meanwhile, Glutathione reduced level (GSH), Glutathione–S-transferase (GST) and catalase activity (CAT) were decreased by ASPadministration. Recovery group showed slight enhancement in all parameters but remained significant as compared to the control group. Co-administration of ASP with silymarin showed greater improvement than the recovery group. Conclusion: Silymarin have an ameliorative role against biochemical oxidative stress, inflammatory changes in blood and different tissues, chromosomal aberrations and MI% induced by ASP administration.

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Section: Histopathological Examinationsupporting

confidence: 91%

Ameliorative Role of Silymarin Against Aspartame–induced Biochemical Changes, Oxidative Stress, Inflammatory Effect and Genotoxicity in Male Albino Rats

Elballat

Abas

2020

Int J Curr Pharm Sci

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“…In addition, rosmarinic acid at the low concentration of 20 mg/kg BW had the ability in rats to increase serum testosterone and sexual behaviour, such as ejaculation, mounts and lordosis in comparison to other groups (Farzadi et al, 2011). Aspartame rats treated with rosemary extract produced a significant increase (P < 0.05) in serum FSH levels compared to the unsupplemented group, but the changes (P>0.05) in LH and testosterone levels were insignificant (Hozayen et al, 2014). Table 4 illustrates the effect of MTS and/or RL supplementations on the liver and renal functions of rabbit bucks.…”

Section: Resultsmentioning

confidence: 99%

“…Similarly, rosemary significantly enhanced glutathione and antioxidant enzyme activities in kidneys and testes compared to aspartame controls (Hozayen et al, 2014 andPerez-Fons et al, 2006). They also observed an almost normal histological architecture of the kidneys in the treated groups compared to the aspartame controls.…”

Section: Data Inmentioning

confidence: 86%

“…Carnosol, rosmanol and epirosmanol phenolic diterpenes of rosemary inhibit lipid peroxidation (Zeng and Wang, 2001). Moreover rosemary significantly attenuated the increase of lipid peroxidation and enhanced the levels of reduced glutathione and antioxidant enzyme activities in the kidney and testis in comparison to aspartame controls (Hozayen et al, 2014;Perez-Fons et al, 2006). The purpose of this study was to investigate the impact of milk thistle seeds and rosemary leaves as antioxidant diet supplements on semen quality, fertility, blood constituents and antioxidant profiles of rabbit bucks.…”

Section: Introductionmentioning

confidence: 99%

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Impact of Supplementation With Milk Thistle Seeds and Rosemary Leaves on Semen Quality, Antioxidants Status and Reproductive Performance of Rabbit Bucks

Hamed

Attila

El-Hamid

et al. 2016

EPSJ

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This experiment aimed at investigating the effects of milk thistle seeds (MTS) and rosemary leaves (RL) at 5 and 10 g/kg diet as feed additives on semen quality, blood metabolites and reproductive performance on rabbit bucks. A total number of 35 male V-line rabbit bucks were distributed randomly into five experimental groups of 7 bucks each. The 1 st group, which served as a control, did not supplement with MTS and RL in their basal diet. The 2 nd and the 3 rd groups were supplemented with MTS at 5 and 10 g/kg in their basal diet, respectively. The 4 th and the 5 th groups were fed the basal diet supplemented with RL at 5 and 10 g/kg, respectively. The best sperm concentration (SC), total sperm output (TSO), live sperm (LS), total live sperm (TLS) and total motile sperm (TMS) were obtained from bucks fed MTS at 10 g/kg diet followed by RL at 5 g/kg diet. Bucks received MTS 10g/kg diet significantly increased their blood serum testosterone compared to the control and this was associated with a significant increase in the fertility rate of the 10 g MTS group. In addition, RL at 5 g/kg significantly increased blood serum testosterone and fertility compared to the control, but the MTS group had the highest serum testosterone and fertility. In conclusion, MTS and RL at 10 and 5g/kg, respectively, significantly improved antioxidant status and liver markers, which led to a significant increase in semen quality and fertility in rabbit bucks.

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“…However, there are inconsistencies in findings between the studies concerning the effects of rosemary on the reproductive system of male mammals. While findings in some studies indicate that rosemary has a contraceptive (Nusier et al, 2007) and deteriorating effects (El-Din et al, 2012;Heidari-Vala et al, 2013) on testicular tissues, findings in other studies indicate that rosemary and its different extracts are able to prevent both functional spermatozoa damage that is induced by cryopreservation (Luno et al, 2014;Motlagh et al, 2014) and various toxicant-induced testicular, hormonal and spermatozoa damage (Hozayen et al, 2014;Uyeturk et al, 2014). In addition, Superchi et al (2005) suggested that the antioxidant activity of rosemary extract limits the negative effects of temperatures that induce HS on reproductive efficiency of boars.…”

Section: Alleviating Effects Of Romentioning

confidence: 99%

Dietary rosemary oil alleviates heat stress-induced structural and functional damage through lipid peroxidation in the testes of growing Japanese quail

Türk

Çeribaşı

Şimşek

et al. 2016

Animal Reproduction Science

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Supplementation of natural antioxidants to diets of male poultry has been reported to be effective in reducing or completely eliminating heat stress (HS)-induced reproductive failures. In this study, the aim is to investigate whether rosemary oil (RO) has a protective effect on HS-induced damage in spermatozoa production, testicular histologic structures, apoptosis, and androgenic receptor (AR) through lipid peroxidation mechanisms in growing Japanese quail. Male chicks (n=90) at 15-days of age were assigned to two groups. The first group (n=45) was kept in a thermo-neutral (TN) room at 22°C for 24h/d. The second group (n=45) was kept in a room with a greater ambient temperature of 34°C for 8h/d (from 9:00 AM to 5:00 PM) and 22°C for 16h/d. Animals in each of these two groups were randomly assigned to three subgroups (RO groups: 0, 125, 250ppm), consisting of 15 chicks (six treatment groups in 2×3 factorial design). Each of subgroups was replicated three times with each replicate including five chicks. The HS treatment significantly reduced the testicular spermatogenic cell counts, amount of testicular Bcl-2 (anti-apoptotic marker) and amount of AR. In addition, it significantly increased testicular lipid peroxidation, Bax (apoptotic marker) immunopositive staining, and the Bax/Bcl-2 ratio in conjunction with some histopathologic damage. Dietary supplementation of RO to diets of quail where the HS treatment was imposed alleviated HS-induced almost all negative changes such as increased testicular lipid peroxidation, decreased numbers of spermatogenic cells, and decreased amounts of Bcl-2 and AR, increased ratio of Bax/Bcl-2 and some testicular histopathologic lesion. In conclusion, dietary supplementation of RO for growing male Japanese quail reared in HS environmental conditions alleviates the HS-induced structural and functional damage by providing a decrease in lipid peroxidation.

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Protective role of aqueous rosemary extract against hepatorenal toxicity of paracetamol in male rats

Cited by 13 publications

References 44 publications

Ameliorative Role of Silymarin Against Aspartame–induced Biochemical Changes, Oxidative Stress, Inflammatory Effect and Genotoxicity in Male Albino Rats

Ameliorative Role of Silymarin Against Aspartame–induced Biochemical Changes, Oxidative Stress, Inflammatory Effect and Genotoxicity in Male Albino Rats

Impact of Supplementation With Milk Thistle Seeds and Rosemary Leaves on Semen Quality, Antioxidants Status and Reproductive Performance of Rabbit Bucks

Dietary rosemary oil alleviates heat stress-induced structural and functional damage through lipid peroxidation in the testes of growing Japanese quail

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