Protective role of epigallocatechin-3-gallate in health and disease: A perspective

Chowdhury, A.A.; Sarkar, Jaganmay; Chakraborti, Tapati; Pramanik, Pijush Kanti; Chakraborti, Sajal

doi:10.1016/j.biopha.2015.12.013

Cited by 144 publications

(85 citation statements)

References 132 publications

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“…It has antiviral, antitumor, antihypertensive, antimalarial and hepatoprotective properties [143]. Some studies have further identified it as a potential therapeutic agent for diseases like Alzheimer's [144] and arthritis [145].…”

Section: Pkc Modulation By Polyphenolsmentioning

confidence: 99%

Polyphenol compounds and PKC signaling

Das

Ramani

Suraju

2016

Biochimica et Biophysica Acta (BBA) - General Subjects

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Background Naturally occurring polyphenols found in food sources provide huge health benefits. Several polyphenolic compounds are implicated in the prevention of disease states, such as cancer. One of the mechanisms by which polyphenols exert their biological actions is by interfering in the protein kinase C (PKC) signaling pathways. PKC belongs to a superfamily of serine-threonine kinase and are primarily involved in phosphorylation of target proteins controlling activation and inhibition of many cellular processes directly or indirectly. Scope of review Despite the availability of substantial literature data on polyphenols' regulation of PKC, no comprehensive review article is currently available on this subject. This article reviews PKC-polyphenol interactions and its relevance to various disease states. In particular, salient features of polyphenols, PKC, interactions of naturally occurring polyphenols with PKC, and future perspective of research on this subject are discussed. Major conclusions Some polyphenols exert their antioxidant properties by regulating the transcription of the antioxidant enzyme genes through PKC signaling. Regulation of PKC by polyphenols is isoform dependent. The activation or inhibition of PKC by polyphenols has been found to be dependent on the presence of membrane, Ca2+ ion, cofactors, cell and tissue types etc. Two polyphenols, curcumin and resveratrol are in clinical trials for the treatment of colon cancer. General significance The fact that 74% of the cancer drugs are derived from natural sources, naturally occurring polyphenols or its simple analogs with improved bioavailability may have the potential to be cancer drugs in the future.

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Section: Pkc Modulation By Polyphenolsmentioning

confidence: 99%

Polyphenol compounds and PKC signaling

Das

Ramani

Suraju

2016

Biochimica et Biophysica Acta (BBA) - General Subjects

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“…Epigallocatechin‐3‐gallate (EGCG) is the major polyphenolic catechin in green tea, accounting for approximately 50–80% of the catechin content; 200 to 300 mg of EGCG is present in a brewed cup of green tea . Although the biological effects of EGCG are not fully understood, studies have indicated that EGCG reduces tumor incidence and multiplicity in different organ sites, and plays roles in cardiovascular, neurodegenerative diseases and metabolic syndromes including obesity, insulin resistance and dyslipidemia . In addition, EGCG has many beneficial effects on different kinds of liver injuries, such as immune‐mediated liver injury, NaF‐induced oxidative hepatic injury, and chronic alcohol‐induced liver injury…”

Section: Introductionmentioning

confidence: 99%

Potential Biological Effects of (‐)‐Epigallocatechin‐3‐gallate on the Treatment of Nonalcoholic Fatty Liver Disease

Cheng

Liu

et al. 2017

Molecular Nutrition Food Res

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Nonalcoholic fatty liver disease (NAFLD) is a major health issue throughout the world. However, no validated treatments for NAFLD are currently available. In‐depth studies have demonstrated the efficacy of (‐)‐epigallocatechin‐3‐gallate (EGCG), a main bioactive chemical extracted from green tea, in treating NAFLD. EGCG exhibits multi‐pronged preventive and therapeutic activities, including promoting lipid and glucose metabolism, anti‐lipid peroxidation and anti‐inflammation activities, anti‐fibrosis, and anti‐NAFLD related tumor, thus contributing to the mitigation of NAFLD occurrence and progression. The objectives of this paper are to review and discuss the currently known targets, signaling pathways and roles of EGCG that interfere with NAFLD pathogenesis, then providing additional experimental evidence and the foundation for the further studies and clinical applications of EGCG in the prevention and treatment of NAFLD.

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“…Numerous epidemiological in vivo and in vitro studies suggest that the molecules present in green tea, chiefly catechins and the most abundant catechin epigallocatechin-3-gallate (EGCG), have many biological activities, including antioxidant, free radical scavenging and iron chelating properties [1–3]. Green tea catechin activity has also been widely associated with cancer prevention and treatment: epidemiological and laboratory studies have found tea consumption inversely associated with the onset and development of certain cancer types [4–7]. EGCG was found to behave as a multitarget molecule, with minimal or no side-effects, numerous sites of action and different mechanisms.…”

Section: Introductionmentioning

confidence: 99%

EGFR inhibition by (-)-epigallocatechin-3-gallate and IIF treatments reduces breast cancer cell invasion

et al. 2017

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Epidermal growth factor receptor (EGFR) expression is an important marker in breast carcinoma pathology and is considered a pivotal molecule for cancer cell proliferation, invasion and metastasis. We investigated the effects of epigallocatechin-3-gallate (EGCG), the most active green tea catechin, in combination with 6-OH-11-O-hydroxyphenanthrene (IIF), a synthetic retinoid X receptor-γ (RXRγ) agonist, on three breast carcinoma cell lines: MCF-7, MCF-7TAM and MDA-MB-231. EGFR and AKT activation and molecular markers of cell motility and migration (CD44, extracellular matrix metalloproteinase (MMP) inducer (EMMPRIN), MMP-2, MMP-9 and tissue inhibitor of metalloproteinases (TIMPs)) were studied after EGCG and IIF treatments. The EGCG + IIF treatment was the most active in down-regulating EGFR phosphorylation at Tyr1068 in all the investigated cell lines; p473AKT was also down-regulated in MCF-TAM cells. EGCG + IIF was also the most active treatment in reducing the expression of markers of invasion and migration in all the three cell lines: CD44, EMMPRIN, MMP-2 and -9 expression decreased, whereas TIMPs were up-regulated. Zymography and scratch assay also confirmed the reduced invasion tendency. We considered that EGCG and IIF treatments could alter the molecular network based on EGFR, CD44 and EMMPRIN expression interdependence and reduced the migration tendency in MCF-7, MCF-7TAM and MDA-MB-231 cells. These events only occurred in association with AKT inactivation in MCF-7TAM cells. In conclusion, the combination of EGCG and IIF significantly attenuated the invasive behaviour of breast carcinoma cells.

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Protective role of epigallocatechin-3-gallate in health and disease: A perspective

Cited by 144 publications

References 132 publications

Polyphenol compounds and PKC signaling

Polyphenol compounds and PKC signaling

Potential Biological Effects of (‐)‐Epigallocatechin‐3‐gallate on the Treatment of Nonalcoholic Fatty Liver Disease

EGFR inhibition by (-)-epigallocatechin-3-gallate and IIF treatments reduces breast cancer cell invasion

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