Protective Role of Epigallocatechin Gallate in a Rat Model of Cisplatin-Induced Cerebral Inflammation and Oxidative Damage: Impact of Modulating NF-κB and Nrf2

Arafa, Manar Hamed; Atteia, Hebatallah Husseini

doi:10.1007/s12640-019-00095-x

Cited by 48 publications

(35 citation statements)

References 117 publications

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“…Therefore, control of inflammatory and oxidative stress responses is of primary importance to avoid deleterious pathological conditions and to counteract drugs' side effects. Polyphenols-rich foods, thanks mainly to their anti-inflammatory and antioxidant potential, are increasingly being used in combination with chemotherapy protocols to improve their efficacy and reduce adverse effects [37][38][39][40][41].…”

Section: Discussionmentioning

confidence: 99%

Bioactive Polyphenols from Pomegranate Juice Reduce 5-Fluorouracil-Induced Intestinal Mucositis in Intestinal Epithelial Cells

et al. 2020

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Intestinal epithelial cells (IECs) play a pivotal role in maintaining intestinal homeostasis. Different noxious agents, among them also anticancer therapies, can impair intestinal epithelial integrity triggering inflammation and oxidative stress. A frequent complication of chemotherapy is gastrointestinal mucositis, strongly influencing the effectiveness of therapy, increasing healthcare costs, and impairing patients’ quality of life. Different strategies are used to treat gastrointestinal mucositis, including products from natural sources. Our study focused on the effect of pomegranate (Punica granatum L.) juice extract on IEC-6 cells, both during inflammatory conditions and following treatment with 5-fluorouracil (5-FU). The polyphenolic profile of pomegranate juice was characterized in detail by Online Comprehensive two dimensional Liquid Chromatography-Mass Spectrometry. The evaluation of pomegranate juice extract in IEC-6 indicates a significant inhibition in proinflammatory factors, such as cytokines release, cyclooxygenase-2 and inducible nitric oxide synthase expression, and nitrotyrosine formation. Pomegranate also inhibited oxidative stress and adhesion protein expression. In 5-FU-treated IEC-6, pomegranate also inhibited both inflammatory and oxidative stress parameters and apoptosis. It promoted wound repair and tight junction expression. These results suggest a potential use of pomegranate as an adjuvant in the treatment of intestinal inflammatory and oxidative stress states, which also occur during chemotherapy-induced mucositis.

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Section: Discussionmentioning

confidence: 99%

Bioactive Polyphenols from Pomegranate Juice Reduce 5-Fluorouracil-Induced Intestinal Mucositis in Intestinal Epithelial Cells

et al. 2020

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“…Glial activation has been reported in some brain areas involved in pain signaling ( 36 , 37 , 70 ). Moreover, the increased levels of the pro-inflammatory cytokines TNF-α, IL-1, and IL-6 were reported in the cerebral cortex or whole brain homogenate of CDDP-treated rats ( 23 , 88 , 89 ). As suggested by the authors, this cytokines increase might have exacerbated the oxidative damage induced by CDDP through glutamate excitotoxicity or the upregulation of NF-κB expression and subsequent overproduction of cytokines.…”

Section: Introductionmentioning

confidence: 94%

“…As suggested by the authors, this cytokines increase might have exacerbated the oxidative damage induced by CDDP through glutamate excitotoxicity or the upregulation of NF-κB expression and subsequent overproduction of cytokines. In fact, the increased transcription and translation of NF-κB gene was found to be associated with a reduction in the nuclear factor erythroid 2-related factor 2 (Nrf2) and HO-1 genes transcription and translation in the brain cortex and hippocampus of CDDP-treated animals ( 89 , 90 ). A strong TNF-α and IL-1β increase associated with IL-10 decrease was also observed in the hippocampus of CDDP-treated rats with cognitive impairment ( 90 , 91 ).…”

Section: Introductionmentioning

confidence: 99%

Neuroinflammatory Process Involved in Different Preclinical Models of Chemotherapy-Induced Peripheral Neuropathy

et al. 2021

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Peripheral neuropathies are characterized by nerves damage and axonal loss, and they could be classified in hereditary or acquired forms. Acquired peripheral neuropathies are associated with several causes, including toxic agent exposure, among which the antineoplastic compounds are responsible for the so called Chemotherapy-Induced Peripheral Neuropathy (CIPN). Several clinical features are related to the use of anticancer drugs which exert their action by affecting different mechanisms and structures of the peripheral nervous system: the axons (axonopathy) or the dorsal root ganglia (DRG) neurons cell body (neuronopathy/ganglionopathy). In addition, antineoplastic treatments may affect the blood brain barrier integrity, leading to cognitive impairment that may be severe and long-lasting. CIPN may affect patient quality of life leading to modification or discontinuation of the anticancer therapy. Although the mechanisms of the damage are not completely understood, several hypotheses have been proposed, among which neuroinflammation is now emerging to be relevant in CIPN pathophysiology. In this review, we consider different aspects of neuro-immune interactions in several CIPN preclinical studies which suggest a critical connection between chemotherapeutic agents and neurotoxicity. The features of the neuroinflammatory processes may be different depending on the type of drug (platinum derivatives, taxanes, vinca alkaloids and proteasome inhibitors). In particular, recent studies have demonstrated an involvement of the immune response (both innate and adaptive) and the stimulation and secretion of mediators (cytokines and chemokines) that may be responsible for the painful symptoms, whereas glial cells such as satellite and Schwann cells might contribute to the maintenance of the neuroinflammatory process in DRG and axons respectively. Moreover, neuroinflammatory components have also been shown in the spinal cord with microglia and astrocytes playing an important role in CIPN development. Taking together, better understanding of these aspects would permit the development of possible strategies in order to improve the management of CIPN.

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“…However, its clinical application has been limited due to multiple toxicities and side effects accrued from its usage (Xing et al 2019;Yucetas et al 2019;Zhang et al 2019). A lot of convincing evidences have implicated ROS generation, oxidative stress and inflammation as the main culprit responsible for cisplatin-evoked toxicity including nephrotoxicity (Arafa and Atteia 2019;Li et al 2018). At present, amifostine, erythropoietin and dexamethasone are the most commonly used chemoprotective agent used for alleviating or preventing cisplatin-induced nephrotoxicity.…”

Section: Discussionmentioning

confidence: 99%

N⁶-2-hydroxyethyl-adenosine ameliorate cisplatin induced acute kidney injury in mice

Yin

Olatunji

et al. 2020

All Life

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N 6-2-hydroxyethyl-adenosine (HEA) is one of the main bioactive components found in Cordyceps cicadae and it has been reported to display antioxidant and anti-inflammatory activities. Cisplatin (CP) is one of the most commonly used chemotherapeutic drug for treating various cancers and tumors, but the use is widely curtailed due to its toxicity of various organs including the kidney. This study was aimed at investigating the protective effect of HEA on cisplatin-induced kidney injury. Mice were pretreated with HEA for 7 days and administered with cisplatin. Kidney function index including blood urea nitrogen (BUN), creatinine, renal oxidative stress and pro-inflammatory indices such as malondialdehyde (MDA), superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GSH-Px), tumor necrosis factor (TNF-α), interleukin 1 beta (IL-1β) and interleukin 6 (IL-6) were measured. Histopathological assessment of the kidney was also performed. The results indicated that HEA noticeably modulated the levels of BUN and creatinine as well as decreased the expression of MDA, TNF-α, IL-1β and IL-6 in the kidney. In addition, HEA up regulated the activities of antioxidant enzymes SOD, CAT and GSH-Px. Therefore, we concluded that HEA could effectively alleviate cisplatin-induced nephrotoxicity by counteracting oxidative stress and inflammation.

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Protective Role of Epigallocatechin Gallate in a Rat Model of Cisplatin-Induced Cerebral Inflammation and Oxidative Damage: Impact of Modulating NF-κB and Nrf2

Cited by 48 publications

References 117 publications

Bioactive Polyphenols from Pomegranate Juice Reduce 5-Fluorouracil-Induced Intestinal Mucositis in Intestinal Epithelial Cells

Bioactive Polyphenols from Pomegranate Juice Reduce 5-Fluorouracil-Induced Intestinal Mucositis in Intestinal Epithelial Cells

Neuroinflammatory Process Involved in Different Preclinical Models of Chemotherapy-Induced Peripheral Neuropathy

N⁶-2-hydroxyethyl-adenosine ameliorate cisplatin induced acute kidney injury in mice

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Protective Role of Epigallocatechin Gallate in a Rat Model of Cisplatin-Induced Cerebral Inflammation and Oxidative Damage: Impact of Modulating NF-κB and Nrf2

Cited by 48 publications

References 117 publications

Bioactive Polyphenols from Pomegranate Juice Reduce 5-Fluorouracil-Induced Intestinal Mucositis in Intestinal Epithelial Cells

Bioactive Polyphenols from Pomegranate Juice Reduce 5-Fluorouracil-Induced Intestinal Mucositis in Intestinal Epithelial Cells

Neuroinflammatory Process Involved in Different Preclinical Models of Chemotherapy-Induced Peripheral Neuropathy

N6-2-hydroxyethyl-adenosine ameliorate cisplatin induced acute kidney injury in mice

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N⁶-2-hydroxyethyl-adenosine ameliorate cisplatin induced acute kidney injury in mice