Protective role of extracts of neem seeds in diabetes caused by streptozotocin in rats

Gupta, S. P.; Kataria, Meena; Gupta, Priyanka; Murganandan, S; YashRoy, Rakesh C.

doi:10.1016/j.jep.2003.09.024

Cited by 117 publications

(73 citation statements)

References 13 publications

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“…The species is presently being cultivated worldwide because of its ability to adapt to different climatic conditions. Biological and pharmacological activities attributed to solvent extracts and products like oil from the different parts of the A. indica are as diverse as antiplasmodial, antitrypanosomal, antioxidant, anticancer, antibacterial, antiviral, larvicidal, fungicidal, antiulcer, spermicidal, anthelminthic, antidiabetic, anti-implantation, immunomodulating, molluscicidal, nematicidal, immunocontraceptive, insecticidal and antifeedant [5][6][7][8][9][10][11][12][13] . Furthermore, the bark of neem tree is known to possess tannins, phenolic compounds (salicylic acid and gallocatechin) which have been reported to be the anti-inflammatory principles [4] .…”

Section: Introductionmentioning

confidence: 99%

Toxicity profile of ethanolic extract of Azadirachta indica stem bark in male Wistar rats

Ashafa

Orekoya

Yakubu

2012

Asian Pacific Journal of Tropical Biomedicine

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Section: Introductionmentioning

confidence: 99%

Toxicity profile of ethanolic extract of Azadirachta indica stem bark in male Wistar rats

Ashafa

Orekoya

Yakubu

2012

Asian Pacific Journal of Tropical Biomedicine

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“…The harmful influence of diabetes on metabolism of tissues and organs is well known. Likewise, uncontrolled hyperglycemia can lead to disturbances in the structure and functions of organs (Gupta et al 2004).…”

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confidence: 99%

Evaluation of trace elements and oxidative stress levels in the liver and kidney of streptozotocin-induced experimental diabetic rat model

Özçelik¹,

Tunçdemi̇r²,

Öztürk³

et al. 2012

gpb

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Abstract. In this study, we aimed to investage the relationship among trace elements (Cu, Fe, Zn and Mg) on oxidative and anti-oxidative substances in liver and kidneys tissues in streptozotocin (STZ) diabetic rat model. The mean levels of Fe and Cu were found significantly higher in the liver and kidneys of the diabetic rats, in comparison to the control rats. On the other hand, the mean levels of Zn and Mg in the liver and kidneys of the diabetic rats were significantly lower than in the control rats.The liver and kidneys malonaldehyde (MDA) levels of the experimental group were found to be higher than in the control group (p < 0.001; p < 0.01, respectively) after 4 weeks of the experimental period. Superoxide dismutase (SOD) activities and glutathione (GSH) levels in the liver tissue of STZ-induced diabetic rats were found to be lower in the experimental group than in the control group (p < 0.01). SOD activity and GSH concentration in kidneys of the diabetic rats were significantly diminished with respect to the control group (p < 0.01). In conclusion, the present results indicate that the increase of Fe and Cu together with decreas of Zn and Mg concentration in liver and kidney of STZ-induced diabetic rats may be involved in disturbances of oxidative balance in both the tissues. Therefore, these findings may contribute to explain the role of impaired ion metabolism of some elements in the progression of diabetic oxidative complications.

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“…20 Hyperglycemia, which leads to cellular tissue damage, was previously reported to induce oxidative stress. 21 In a previous study, Alloxan-induced diabetes caused significant decrease in SOD, CAT, and GPx activities as well as significant increase in MDA production. 22 These changes reflect oxidative stress which may be mirror a decreased antioxidant defense potential.…”

Section: Figure (2)mentioning

confidence: 85%

Arabic gum acacia improves diabetic peripheral neuropathy in rats: a biochemical and histopathological evidence

Almohaimeed

Amin

El-Aziz

et al. 2018

Int J Basic Clin Pharmacol

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INTRODUCTIONDiabetes mellitus (DM) is thought to be a noteworthy risk to public health. Data from the World Health Organization (WHO) showed that almost half of all deaths attributable to high blood glucose occur before the age of 70 years. WHO projects that diabetes will be the seventh leading cause of death in 2030. 1 Diabetic peripheral neuropathy (DPN) is a frequent complication of diabetes mellitus.Studies conducted in the Middle East revealed high rates of DPN ranged from 35% to 65%. The DPN is more frequently represented than other complications of Diabetes Mellitus. It was reported that it is responsible for 50%-75% of non-traumatic amputations. Painful DPN has high grade of functional disability which influences health-related quality of life. 2 Hyperglycemia is basic for occurrence and advancement of DPN with the etiological hypotheses on metabolic or vascular causes. 3 Regardless of numerous investigations on DPN, the present ABSTRACT Background: Diabetic peripheral neuropathy (DPN) is a frequent complication of diabetes mellitus and unfortunately, its present therapeutic alternatives are exceptionally poor. Objectives of this study was to assess the antidiabetic, antioxidant and hypolipidemic action of Gum Arabic (GA) and its role in promoting the functional recovery from diabetic neuropathy developed in in an experimental model of diabetic neuropathy. Methods: Sixty adult male Sprague-Dawley rats were utilized and randomly assigned into six groups (n= 10); control, Arabic gum-treated, untreated diabetic, diabetic received metformin, diabetic received metformin and B12 vitamin and diabetic received metformin, B12 vitamin and AG. Locomotor activity and hyperalgesia were assed at the end of the study. Fasting and two hours postprandial blood glucose, serum insulin levels, lipid Profile, oxidants/antioxidants parameters were assessed in the blood. Sciatic nerve was assessed histopathologically. Results: The locomotor activity of the untreated diabetic rats was significantly (p<0.001) reduced compared to the control group while it was significantly increased in all treated groups. The lipid profile and Malondialdehyde were significantly improved in all treated groups. Levels of CAT, GSH, SOD, GPx were significantly decreased in untreated diabetic group compared to the control while they were significantly increased in all treated groups compared to the untreated diabetic group. Sciatic nerve fibers of untreated diabetic rats showed degenerated axons with dilated myelin sheaths and degenerated Schwann cells. The nerve had significantly fewer fiber compared to the control. These changes were alleviated in all the treated groups specifically that received metformin, vitamin B12 and GA. Conclusions: It could be concluded that Arabic gum had hypoglycemic, antioxidant and hypolipidemic activity and had a protective effect on diabetic neuropathy. Based on this it is recommended that human clinical trials are necessary to prove this therapeutic effect.

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Protective role of extracts of neem seeds in diabetes caused by streptozotocin in rats

Cited by 117 publications

References 13 publications

Toxicity profile of ethanolic extract of Azadirachta indica stem bark in male Wistar rats

Toxicity profile of ethanolic extract of Azadirachta indica stem bark in male Wistar rats

Evaluation of trace elements and oxidative stress levels in the liver and kidney of streptozotocin-induced experimental diabetic rat model

Arabic gum acacia improves diabetic peripheral neuropathy in rats: a biochemical and histopathological evidence

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Protective role of extracts of neem seeds in diabetes caused by streptozotocin in rats

Cited by 117 publications

References 13 publications

Toxicity profile of ethanolic extract of Azadirachta indica stem bark in male Wistar rats

Toxicity profile of ethanolic extract of Azadirachta indica stem bark in male Wistar rats

Evaluation of trace elements and oxidative stress levels in the liver and kidney of streptozotocin-induced experimental diabetic rat model

Arabic gum acacia improves diabetic peripheral neuropathy in rats: a biochemical and histopathological evidence

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Product

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Evaluation of trace elements and oxidative stress levels in the liver and kidney of streptozotocin-induced experimental diabetic rat model