Protective Role of Golden Flaxseed (<i>Linum usitatissimum</i> L.) Against Oxidative Damage in Lipids and Proteins of Healthy Volunteers

Abstract

Flaxseed (Linum usitatissimum L.) is composed mainly of bioactive components such as polyphenols, polyunsaturated fatty acids, fiber and lignans. Flaxseed can be found in different presentation forms (grain or flour) and varieties (brown or golden); however, questions have arisen as to whether the presentation form and/or variety may influence the health effects. The objective of this study was to evaluate the effects on blood pressure, anthropometric and oxidative parameters in healthy human volunteers. All subjects received 40 gram aliquots of flaxseed and were instructed to consume them in their entirety mixed with water in the morning for a period of 14 days. Oxidative parameters showed significant reductions (p < 0.05) in oxidative damage to lipids and proteins via dietary intervention with golden flaxseed grains. There were no significant differences in anthropometric parameters, blood pressure, DNA damage and micronuclei frequency after 14-day supplementation. This research indicates that golden flaxseed grains can be a valuable adjunct for disease prevention and protecting the organism against oxidative damage.

Protective Role of Flaxseed Oil and Flaxseed Lignan Secoisolariciresinol Diglucoside Against Oxidative Stress in Rats with Metabolic Syndrome

“…In the micronucleus frequency and comet assay, all groups exhibited normal values, demonstrating that the components of flaxseed are not able to produce cytogenetic changes. These findings are consistent with previous studies (Pilar and others ; Zuravski and others ).…”

“…However, no significant differences were observed in CAT activity between the control and MS groups, which is in line with the findings of Bagul and others (), who also found no differences in this enzyme activity in animals fed a high‐fructose diet compared with those fed a standard diet. Furthermore, the increase in activities of these 3 enzymes in groups that received FO and SDG shows that both substances can positively affect enzymatic antioxidant defenses both in healthy and MS groups, which is consistent with findings from previous studies (Tayyebi‐Khosroshahi and others ; Pilar and others ; Zuravski and others ; Sawant and Bodhankar ). However, we observed a greater increase in groups treated with SDG, demonstrating the greater antioxidant power of this component.…”

“…Furthermore, studies have shown that flaxseed can reduce oxidative damage, including in MS patients (Pilar and others ; Zuravski and others ). However, some studies attribute these effects to FO and its high ALA concentration (Karaka and Eraslan ; Badawy and others ), whereas other studies indicate that the antioxidant effects of flaxseed are due to the presence of its lignans, especially SDG (Hu and others ; Newary and Abdou ).…”

Immunotoxicological Evaluation of Schinus molle L. (Anacardiaceae) Essential Oil in Lymphocytes and Macrophages

“…The lymphocyte cultures were prepared using 0.5 ml of venous blood (collected by voluntary venipuncture) and immediately transferred to a culture medium containing 10 ml of RPMI 1640 supplemented with 10% fetal bovine serum (FBS) and 1% streptomycin-penicillin, as described in previous work by our group [ 5 , 8 , 9 ] and approved by the Research Ethics Committee of the Federal University of Pampa (n°. 27045614.0.0000.5323).…”

A systematic review and meta-analysis of clinical trials investigating the effects of flaxseed supplementation on plasma C-reactive protein concentrations

“…The translation of the Latin origin of the name, meaning “very useful”, is suggestive, considering the various products with biological effects that contain flaxseed and its fractions: flaxseed oil, whole seed, flaxseed meal, flaxseed mucilage and/or alcohol extracts, flaxseed hulls, ground whole seed, and flaxseed oleosomes [2]. Two major varieties of flaxseed products are available, but with different biological activity [1, 3]. Flaxseed contains one-third soluble and two-thirds insoluble fibres from a total of 35–45% of fibres.…”