Protective role of green tea on diabetic nephropathy—A review

Mohib, Mohammad Mohabbulla; Rabby, S.M. Fazla; Paran, Tasfiq Zaman; Hasan, Md. Mehedee; Ahmed, Iqbal Ike K.; Hasan, Nahid; Sagor, Md. Abu Taher; Mohiuddin, Mohammad Sarif

doi:10.1080/23312025.2016.1248166

Cited by 26 publications

(16 citation statements)

References 158 publications

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“…12 ml/l for 24 h and 10 ml/l for 96 h there was no mortality occurred. But as the concentrations increased above these levels mortality occurred again on 14 ml/l and 12 ml/l for 24 and 96 h. This may be due the fact that besides being beneficial impact flavonoids can cause toxicity as evidenced earlier [25,58,59].…”

Section: Discussionmentioning

confidence: 79%

Imidacloprid Toxicity and Its Attenuation by Aqueous Extract of Moringa Oleifera Leaf in Zebra Fish, Danio Rerio

Yadav

Ahmad

Zahra

2020

Int J Curr Pharm Sci

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Objective: Imidacloprid (IMC) is a systemic chloro-nicotinyl insecticide that is applied in crop fields to control a wide variety of harmful insects and pests. The objective of the present study was to evaluate the mitigating effects of Moringa leaf extract (MLE) against Imidacloprid (IMC) induced mortality after acute toxicity bioassay in zebrafish, Danio rerio. Methods: The fishes were exposed to various concentrations of IMC to estimate the LC50 values at different exposure periods using the probit analysis. To assess the attenuating effect on mortality fishes were exposed to different concentrations of MLE along with 24 and 96 h LC50 of IMC. Mortality rate of fishes was recorded during all experimental periods. Results: The LC50 values were found to be 0.423, 0.352, 0.297 and 0.270 ml/l after 24, 48, 72 and 96 h respectively. The upper confidence limits were 0.491, 0.408, 0.334 and 0.302 ml/l and lower confidence limits were 0.355, 0.296, 0.260 and 0.238 ml/l for 24, 48, 72 and 96 h respectively. The fishes remain alive at 12 ml/l and 10 ml/l of MLE against 24 and 96 h LC50 respectively. Some behavioral responses such as violent, sluggish and erratic movement, respiratory distress, mucous secretion all over the body, discoloration were also observed in IMC treated fishes in comparison to MLE treated fishes. Conclusion: These findings demonstrated that MLE has mitigating effects against the toxic influence of IMC on mortality in zebra fishes which is attributed to its antioxidant effects.

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Section: Discussionmentioning

confidence: 79%

Imidacloprid Toxicity and Its Attenuation by Aqueous Extract of Moringa Oleifera Leaf in Zebra Fish, Danio Rerio

Yadav

Ahmad

Zahra

2020

Int J Curr Pharm Sci

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“…Further, Yamabe et al reported the positive effect of epigallocatechin gallate (EGCG), the most active green tea polyphenol, on the symptoms of diabetic nephropathy in rats, along with downregulation of TGF-β expression [ 85 ]. However, the underlying mechanisms of the renoprotective effect of the polyphenols have been elusive [ 86 ]. Recently, we discovered that EGCG activates DGKα, suggesting DGKα is involved in the renoprotective effect of green tea polyphenols [ 87 ].…”

Section: Diabetic Nephropathy and Dgkmentioning

confidence: 99%

The Role of Diacylglycerol Kinase in the Amelioration of Diabetic Nephropathy

Hayashi

Shirai

2022

Molecules

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The drastic increase in the number of patients with diabetes and its complications is a global issue. Diabetic nephropathy, the leading cause of chronic kidney disease, significantly affects patients’ quality of life and medical expenses. Furthermore, there are limited drugs for treating diabetic nephropathy patients. Impaired lipid signaling, especially abnormal protein kinase C (PKC) activation by de novo-synthesized diacylglycerol (DG) under high blood glucose, is one of the causes of diabetic nephropathy. DG kinase (DGK) is an enzyme that phosphorylates DG and generates phosphatidic acid, i.e., DGK can inhibit PKC activation under diabetic conditions. Indeed, it has been proven that DGK activation ameliorates diabetic nephropathy. In this review, we summarize the involvement of PKC and DGK in diabetic nephropathy as therapeutic targets, and its mechanisms, by referring to our recent study.

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“…It can also occur even if there is sufficient insulin present, from reduced Glucose Transporter Type (GLUT)-4 or reduced insulin binding to its receptor. Obesity plays a major role in the development of diabetes and insulin resistance (Mohabbulla Mohib et al, 2016). Tomato appears to regulate insulin mechanisms and control HbA1c levels in diabetics and healthy adults (Alam et al, 2019).…”

Section: Diabetes Melitusmentioning

confidence: 99%

Tomato Role on Seven Deadliest Non-Communicable Disease

Zulfa¹,

Salim

Silalahi

et al. 2021

jiss

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Non-communicable diseases such as ischemic heart disease, stroke, chronic obstructive pulmonary disease, lung cancer, Alzheimer, diabetes melitus, and kidney disease are leading causes of death in the world. There are many risk factors which can contribute to non-communicable diseases such as dietary. Vegetable consumption such as tomato may lower risk factors to non-communicable diseases because of its active ingredient, lycopene, retinol, alpha tomatine, and tomatidine. In this study, authors aim to explain the mechanism of tomato’s active compound in lowering risk factors of non-communicable disease based on biomarker found on each disease collected from recent epidemiological, in silico, in vitro, and in vivo researches. Lycopene and retinol have proven in reducing ischemic heart disease and stroke because of its anti-atherogenic properties and anti-inflammatory effect. Anti-oxidative and anti-inflammatory effect of lycopene also proven in lowering risk factors of chronic obstructive pulmonary diseases by modulate reverse cholesterol transport, so cholesterol homeostasis is created. In lung cancer, lycopene and other bioactive compound such as α-tomatine and tomatidine also have an anti-proliferative effect by interacting with Epidermal growth factor receptor (EGFR). Its ability to reduce the final product of lipid peroxidation level makes lycopene lower Alzheimer risk factor. There is much more function of tomato’s active coumpound although pure tomato has contradictive effect on some disease.

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Protective role of green tea on diabetic nephropathy—A review

Cited by 26 publications

References 158 publications

Imidacloprid Toxicity and Its Attenuation by Aqueous Extract of Moringa Oleifera Leaf in Zebra Fish, Danio Rerio

Imidacloprid Toxicity and Its Attenuation by Aqueous Extract of Moringa Oleifera Leaf in Zebra Fish, Danio Rerio

The Role of Diacylglycerol Kinase in the Amelioration of Diabetic Nephropathy

Tomato Role on Seven Deadliest Non-Communicable Disease

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