Protective role of Helicobacter pylori infection in gastroesophageal reflux disease

Varanasi, Ravikant V.; Fantry, George T.; Wilson, K.T.

doi:10.1016/s0016-5085(98)81308-5

Cited by 4 publications

(2 citation statements)

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“…Reports 7,8 to date have been conflicting, with some authors arguing an important role for H pylori in GERD and others arguing that it does not play a role. Recent data suggest that H pylori may actually protect against the development of erosive esophagitis, 9,10 Barrett esophagus, and esophageal adenocarcinoma. 11 Furthermore, it has been suggested that eradication of H pylori may precipitate reflux esophagitis in patients with duodenal ulcers.…”

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confidence: 99%

Helicobacter pylori Is Not Associated With the Manifestations of Gastroesophageal Reflux Disease

Öberg

Peters²,

Nigro³

et al. 1999

Arch Surg

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Helicobacter pylori is not associated with gastroesophageal reflux disease and its complications, including adenocarcinoma of the esophagus and the gastroesophageal junction (GEJ). Design: Retrospective analysis. Setting: University tertiary referral center. Patients: Two hundred twenty-nine patients with symptoms suggestive of foregut disease underwent esophageal manometry, 24-hour pH monitoring, and upper gastrointestinal tract endoscopy, with biopsy specimens obtained from the gastric antrum, the GEJ, and the distal esophagus. In these and in an additional 114 patients with adenocarcinoma of the esophagus and the GEJ, the presence of H pylori was determined by Giemsa stain. The presence of gastroesophageal reflux disease, defined by abnormal esophageal acid exposure, and its manifestations (carditis, erosive esophagitis, intestinal metaplasia limited to the GEJ, Barrett esophagus, and adenocarcinoma of the esophagus and GEJ) were correlated with the presence of H pylori. Results: Helicobacter pylori was found on the biopsy specimens of the gastric antrum in 14.0% (32/229) of the patients with benign disease. It was not related to the features of gastroesophageal reflux disease, including abnormal esophageal acid exposure, erosive esophagitis, or Barrett esophagus. The presence of inflamed cardiac mucosa at the GEJ or carditis was inversely related to H pylori infection and strongly associated with increased esophageal acid exposure. There was no association between the presence of intestinal metaplasia and H pylori infection. Helicobacter pylori was found in 22 (19.3%) of the 114 patients with esophageal adenocarcinoma, which was not different from the prevalence of H pylori in patients with benign disease. Conclusion: Helicobacter pylori plays no role in the pathogenesis of gastroesophageal reflux disease or its complications.

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confidence: 99%

Helicobacter pylori Is Not Associated With the Manifestations of Gastroesophageal Reflux Disease

Öberg

Peters²,

Nigro³

et al. 1999

Arch Surg

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“…The relationship between the two remains controversial. Certain studies showed a protective role of HP infection in GERD [39][40][41], others showed that eradi cation of HP increased the incidence of GERD-type symp toms or endoscopic esophagitis [42,43], or increased acid secretion [44]. Another study showed that HP infection fur ther accelerates healing of grade II and III reflux esophagi tis in patients taking pantoprazole [45].…”

Section: Relationship Between Hp Infection and Gerdmentioning

confidence: 99%