Protective Role of Hsp27 Protein Against Gamma Radiation–Induced Apoptosis and Radiosensitization Effects of Hsp27 Gene Silencing in Different Human Tumor Cells

Inhibition of heat shock protein 27 (HspB1) tumorigenic functions by peptide aptamers

“…Overexpression of this protein is frequently associated with increased resistance to radiotherapy and to anti-cancer drugs, such as cisplatin, doxorubicin and etoposide (Hansen et al, 1999;Kim et al, 2007;Zhang and Shen, 2007). Others and we have shown that targeting Hsp27 by antisense strategy increases cancer cell death in vitro and in vivo (Aloy et al, 2008;Matsui et al, 2009).…”

“…We have previously shown that targeting Hsp27 by antisense approach sensitizes the radioresistant SQ20B cells to g-irradiation (Aloy et al, 2008). To test the radiosensitizing effect of PAs, cell survival curves were established after irradiation of SQ20B-PAs and SQ20B-PAc control cells at doses varying between 1 and 8 Gy.…”

Immune independent crosstalk between lymphoma and myeloid suppressor CD14+HLA-DRlow/negmonocytes mediates chemotherapy resistance

“…Hsp27 has been found to mediate anti-apoptotic, pro-survival signaling and resistance to treatments with cisplatin 30 and radiation 31 in solid tumors and bortezomib in lymphoma. 26,32 Blockade of Hsp27 reversed this treatment resistance effect.…”

Impact of hyperthermic intraperitoneal chemotherapy on Hsp27 protein expression in serum of patients with peritoneal carcinomatosis

“…By regulating the metabolism of glutathione (a major intracellular antioxidant) through the activation of glucose-6-phosphate dehydrogenase, Hsp27 protects cells from oxidative stress. Hsp27 can inhibit apoptosis through direct interaction with cytochrome c and inhibition of caspase activation and is also involved in the regulation of the Akt serine/threonine protein kinase pathway involved in cell survival (Aloy et al 2008;Havasi et al 2008). Because the overexpression of Hsp27 is frequently associated with thermotolerance and chemoresistance (Takhashi et al 2008;Li et al 1995), it appears to be a good candidate for explaining resistance to HIPEC.…”