Protective Role of Hypericum perforatum L. and Hypericum triquetrifolium Turra against Inflammatory Diseases: Evidence  from In vitro and In vivo Studies

Kmail, Abdalsalam

doi:10.9734/ejmp/2022/v33i121112

Cited by 4 publications

(1 citation statement)

References 49 publications

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“…Plant-based medications and other botanicals have become increasingly popular in the Western world in recent years [4]. Plant extracts and their active compounds have the ability to modulate inflammation at the cellular level as well as growth factors, and cytokines which involved in skin diseases [5,6]. Natural chemicals can aid in the production of new blood vessels, connective tissue development, and skin cell repair [7,8].…”

Section: Introductionmentioning

confidence: 99%

"The Benefits of Nigella sativa for Skin Diseases and Heal Skin Injuries: An Overview of Phytochemicals and Pharmacological Properties"

Kmail

2023

BJSTR

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Nigella sativa (N. sativa) is a medicinal plant with a long history of use in various traditional systems of medicine, such as Arab and Islamic medicine, Unani, Ayurveda, and Chinese medicine. N. sativa has many active compounds, such as alkaloids, saponins, and thymoquinone, that give it a wide range of health benefits. It can act as a diuretic, bronchodilator, antihypertensive, antidiabetic, and analgesic. Moreover, N. sativa has antimicrobial, anti-inflammatory, and antineoplastic properties, which make it a promising natural treatment for skin conditions. This article summarizes the current evidence on the effects of N. sativa for the management of acne vulgaris, melanoma, vitiligo, atopic dermatitis, plaque psoriasis, and wound healing. This review examines the most recent studies on the role of N. sativa in preventing and treating skin diseases and injuries, with a focus on its phytochemicals and pharmacological properties. We conducted a comprehensive literature review using various electronic databases, including Google Scholar, PubMed, Science Direct, and MedlinePlus, to collect data on the therapeutic properties of N. sativa and thymoquinone in skin disorders. Our findings provide substantial evidence supporting the efficacy of N. sativa/thymoquinone in facilitating the healing of a variety of skin diseases. However, it is essential to establish the most effective treatment dosages and the optimal administration route. Further research is also required to explore potential side effects and to evaluate the performance of these natural products in clinical trials.

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Section: Introductionmentioning

confidence: 99%

"The Benefits of Nigella sativa for Skin Diseases and Heal Skin Injuries: An Overview of Phytochemicals and Pharmacological Properties"

Kmail

2023

BJSTR

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Analysis of the underlying mechanism of Ziziphi Spinosae Semen for treating anxiety disorder in a zebrafish sleep deprivation model

Zhang,

Feng,

Feng

2024

Pharmaceutical Science Advances

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Anti-leishmanial activity of Hypericum Scabrum extract against Leishmania major

Saberi,

Jamshidzad,

Karimi

et al. 2024

AMB Expr

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Leishmaniasis is a vector-borne disease and one of the most significant neglected tropical diseases. Current anti-leishmanial treatments are often ineffective over extended periods and are associated with toxic side effects, highlighting the urgent need for new, effective, and safe alternative treatments for this infectious disease. The objective of this study was to evaluate the anti-leishmanial effects of a hydroalcoholic extract of Hypericum scabrum ( H. scabrum ), comparing its efficacy to that of the control drug glucantime against the standard strain of Leishmania major . The H. scabrum plants were collected from the western regions of Iran. A hydroalcoholic extract was prepared from the flower and stem of the plant using a maceration method. High-performance liquid chromatography analysis was conducted to identify the chemical compounds present in the extract. Promastigotes of L. major were cultured, and the anti-leishmanial activity of the extracts was assessed at concentrations ranging from 12.5 to 800 µg/ml using the MTT [3-(4,5-Dimethylthiazol-2-yl)-2,5-Diphenyltetrazolium Bromide] assay. The half-maximal inhibitory concentration (IC50) values for the H. scabrum plant extract at 24, 48, and 72 h were 245.47, 141.25 and 85.11 μg/ml, respectively. The IC50 values for glucantime (the control drug) at 24 h, 48 h, and 72 h were 30.19, 21.37, and 12.58 μg/ml, respectively. While the H. scabrum extract exhibited a lower effect compared to the control drug, it still demonstrated a significant inhibitory effect on the promastigote form of L. major . Given that the plant extract of H. scabrum has demonstrated promising anti-leishmanial effects against L. major promastigotes, further studies are warranted to evaluate the efficacy of these extracts in animal models of leishmaniasis .

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Protective Role of Hypericum perforatum L. and Hypericum triquetrifolium Turra against Inflammatory Diseases: Evidence from In vitro and In vivo Studies

Cited by 4 publications

References 49 publications

"The Benefits of Nigella sativa for Skin Diseases and Heal Skin Injuries: An Overview of Phytochemicals and Pharmacological Properties"

"The Benefits of Nigella sativa for Skin Diseases and Heal Skin Injuries: An Overview of Phytochemicals and Pharmacological Properties"

Analysis of the underlying mechanism of Ziziphi Spinosae Semen for treating anxiety disorder in a zebrafish sleep deprivation model

Anti-leishmanial activity of Hypericum Scabrum extract against Leishmania major

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