Protective role of lycopene and vitamin E against diazinon-induced biochemical changes in Oreochromis niloticus

Ahmed, Th A Ibrahim

doi:10.5897/ajest2014.1853

Cited by 23 publications

(2 citation statements)

References 31 publications

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“…Two processes that contribute to lycopene’s antioxidative impact are the formation of adducts and allylic hydrogen abstraction [ 107 , 108 ]. The type of the reacting free radical, the structural characteristics of lycopene, and the positioning and direction of lycopene inside the membrane in biological systems are all elements that impact these potential interactions [ 109 , 110 , 111 ].…”

Section: Lycopene As An Antioxidantmentioning

confidence: 99%

Lycopene: A Natural Arsenal in the War against Oxidative Stress and Cardiovascular Diseases

et al. 2022

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Lycopene is a bioactive red pigment found in plants, especially in red fruits and vegetables, including tomato, pink guava, papaya, pink grapefruit, and watermelon. Several research reports have advocated its positive impact on human health and physiology. For humans, lycopene is an essential substance obtained from dietary sources to fulfil the body requirements. The production of reactive oxygen species (ROS) causing oxidative stress and downstream complications include one of the major health concerns worldwide. In recent years, oxidative stress and its counter strategies have attracted biomedical research in order to manage the emerging health issues. Lycopene has been reported to directly interact with ROS, which can help to prevent chronic diseases, including diabetes and neurodegenerative and cardiovascular diseases. In this context, the present review article was written to provide an accumulative account of protective and ameliorative effects of lycopene on coronary artery disease (CAD) and hypertension, which are the leading causes of death worldwide. Lycopene is a potent antioxidant that fights ROS and, subsequently, complications. It reduces blood pressure via inhibiting the angiotensin-converting enzyme and regulating nitrous oxide bioavailability. It plays an important role in lowering of LDL (low-density lipoproteins) and improving HDL (high-density lipoproteins) levels to minimize atherosclerosis, which protects the onset of coronary artery disease and hypertension. Various studies have advocated that lycopene exhibited a combating competence in the treatment of these diseases. Owing to all the antioxidant, anti-diabetic, and anti-hypertensive properties, lycopene provides a potential nutraceutical with a protective and curing ability against coronary artery disease and hypertension.

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Section: Lycopene As An Antioxidantmentioning

confidence: 99%

Lycopene: A Natural Arsenal in the War against Oxidative Stress and Cardiovascular Diseases

et al. 2022

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“…Through their actions, toxins disrupt homeostasis, alter gene expression, and cancer-related metabolic signalling pathways [ 224 ]. Research has demonstrated that lycopene as a dietary supplement effectively mitigates the deleterious effects of myco-, bacterial, and chemical toxins [ 225 ] [ 125 , 226 , 227 ], fungicides [ 228 ], pesticides [ 229 ], herbicides [ 230 ], and fluoride [ 231 ]. It is hypothesised that lycopene mediates protection against toxins through its potent antioxidant, chelating, and antiapoptotic properties [ 224 ].…”

Section: Lycopene: Protective Effects Against Toxinsmentioning

confidence: 99%

Lycopene: A Potent Antioxidant with Multiple Health Benefits

Shafe,

Gumede,

Nyakudya

et al. 2024

Journal of Nutrition and Metabolism

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Lycopene is a naturally occurring carotenoid predominantly found in tomatoes and tomato‐based products. Like other phytochemicals, it exhibits health beneficial biological activities that can be exploited when it is used as a dietary supplement. In vitro and in vivo, lycopene has been demonstrated to mitigate oxidative stress‐induced metabolic dysfunctions and diseases including inflammation, obesity, and diabetes mellitus. Lycopene has been shown to alleviate metabolic diseases that affect the bone, eye, kidney, liver, lungs, heart, and nervous system. This review presents the state of the art regarding lycopene’s health benefits and its potential applications in health system delivery. Furthermore, lycopene’s protective effects against toxins, safety in its use, and possible toxicity are explored.

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Protective effect of lycopene against chemical and natural toxins: A review

et al. 2018

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People are exposed to a number of environmental, occupational, and therapeutic toxic agents which may be natural or man made. These hazardous substances may manifest as direct side effects on the function of organs or indirectly induced alteration of gene expression, cancer‐associated metabolic pathways, and/or alter homeostasis. Lycopene, as a one of the most potent antioxidant, is found in fruits and vegetables. High‐intake of lycopene has been shown to be effective in decreasing the risk of both natural toxins including mycotoxins, bacterial toxins, and chemical toxins including heavy metals, pesticides as well as herbicides. Recently, there is growing attention in understanding the mechanisms of the phytochemicals and carotenoids as antioxidative, antiapoptotic, radical scavenging, and chelating agents and their roles in the modulation of inflammatory pathways. This review summarizes available data from several recent studies about lycopene and its role against chemical and natural toxicants. © 2018 BioFactors, 45(1):5–23, 2019

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Protective role of lycopene and vitamin E against diazinon-induced biochemical changes in Oreochromis niloticus

Cited by 23 publications

References 31 publications

Lycopene: A Natural Arsenal in the War against Oxidative Stress and Cardiovascular Diseases

Lycopene: A Natural Arsenal in the War against Oxidative Stress and Cardiovascular Diseases

Lycopene: A Potent Antioxidant with Multiple Health Benefits

Protective effect of lycopene against chemical and natural toxins: A review

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