Protective role of melatonin in breast cancer: what we can learn from women with blindness

Minella, Chris; Coliat, Pierre; Amé, Shanti; Neuberger, Karl; Stora, Alexandre; Mathelin, Carole; Reix, Nathalie

doi:10.1007/s10552-021-01502-5

Cited by 5 publications

(5 citation statements)

References 95 publications

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“…According to Minella et al, variations in melatonin levels have been identified across the phases of menstruation. Therefore, increased plasma melatonin was seen in women in LP (luteal-phase) than FP (follicular-phase) [73]. There was also an increase in the melatonin levels in the participants taking a three-phase contraceptive pill.…”

Section: Menstrual Cyclementioning

confidence: 89%

“…Moreover, evidence from studies suggests that the interaction of melatonin and sex hormones results from localizing melatonin receptors with progesterone and estrogen in the periphery and brain, including the increased melatonin receptors in the reproductive tissues [70,73]. The study also reported a marked increase in melatonin secretion in women using oral contraceptives, particularly synthetic progesterone, as well as melatonin treatment could be essential in enhancing human chronic gonadotropin-stimulated progesterone secretion in human granulosa cells [73]. In contrast, in a low estrogen environment and premenopausal women, oophorectomy contributes to substantially increased melatonin secretion [74].…”

Section: Menstrual Cyclementioning

confidence: 99%

“…While others, including citalopram, showed no effect. Minella et al (2021) add that tricyclic antidepressants enhance the onset of melatonin and intensify the nocturnal plasma melatonin in people since it acts as noradrenaline re-uptake inhibitors [73].…”

Section: Drugsmentioning

confidence: 99%

“…Cigarettes usually contain polycyclic aromatic hydrocarbons that usually contain CYP1A2 activity, which is required for the metabolism of melatonin in the liver [62,73]. Therefore, the level of melatonin in habitual smokers is usually low.…”

Section: Nicotinementioning

confidence: 99%

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Characteristic, Synthesis, and Non-Photic Regulation of Endogenous Melatonin

Albreiki¹

2022

Melatonin - Recent Updates

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Several researchers have confirmed that the melatonin hormone is significant to the body’s circadian rhythm, hence, the need to explore the connection between the two aspects. The circadian rhythm is a natural endogenous process that controls essential body functions as it affects hormone release, body temperature, sleep patterns, and eating habits. In that view, the circadian rhythm relies on melatonin to synchronize the night and day cycles. Melatonin plays a significant role in controlling the circadian rhythm by facilitating quality sleep at night and alertness during the day. In effect, understanding the acute non-image-forming visual effects of melatonin will help derive ways to ensure the circadian rhythms operate efficiently for healthy body functions.

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Section: Menstrual Cyclementioning

confidence: 89%

Section: Menstrual Cyclementioning

confidence: 99%

Section: Drugsmentioning

confidence: 99%

Section: Nicotinementioning

confidence: 99%

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Characteristic, Synthesis, and Non-Photic Regulation of Endogenous Melatonin

Albreiki¹

2022

Melatonin - Recent Updates

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“…Individuals with limited light perception have an abnormal circadian rhythm, which has been treated with daily administration of melatonin [ 182 , 183 ]. Since visually impaired individuals tend to have higher levels of BMI [ 186 ], assessing the potential benefits/challenges of melatonin administration on metabolism, along with a possible link with cancer [ 187 ] in blind individuals, will be of great importance going forward.…”

Section: Variability In Response To Lightmentioning

confidence: 99%

The Complex Effects of Light on Metabolism in Humans

Courville

Chen

2023

Nutrients

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Light is an essential part of many life forms. The natural light–dark cycle has been the dominant stimulus for circadian rhythms throughout human evolution. Artificial light has restructured human activity and provided opportunities to extend the day without reliance on natural day–night cycles. The increase in light exposure at unwanted times or a reduced dynamic range of light between the daytime and nighttime has introduced negative consequences for human health. Light exposure is closely linked to sleep–wake regulation, activity and eating patterns, body temperature, and energy metabolism. Disruptions to these areas due to light are linked to metabolic abnormalities such as an increased risk of obesity and diabetes. Research has revealed that various properties of light influence metabolism. This review will highlight the complex role of light in human physiology, with a specific emphasis on metabolic regulation from the perspective of four main properties of light (intensity, duration, timing of exposure, and wavelength). We also discuss the potential influence of the key circadian hormone melatonin on sleep and metabolic physiology. We explore the relationship between light and metabolism through circadian physiology in various populations to understand the optimal use of light to mitigate short and long-term health consequences.

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