Protective role of osteocalcin in diabetes pathogenesis

Desentis-Desentis, María Fernanda; Rivas‐Carrillo, Jorge David; Sánchez‐Enríquez, Sergio

doi:10.1007/s00774-020-01130-0

Cited by 12 publications

(6 citation statements)

References 38 publications

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“…In animal models, osteocalcin, an extrahepatic VKDP that is activated by VK2, has reduced insulin resistance [ 36 , 151 ]. Other studies support the argument that osteocalcin might play an important role in type II diabetes [ 147 , 152 , 153 ]. Osteoporosis is frequently found in AD patients, and there is an increased risk of fractures in individuals with dementia [ 154 , 155 , 156 ].…”

Section: Vitamin K2 and Alzheimer’s Diseasementioning

confidence: 59%

Vitamin K2 Holds Promise for Alzheimer’s Prevention and Treatment

Popescu¹,

German

2021

Nutrients

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Recent studies have highlighted the importance of vitamin K2 (VK2) in human health. However, there have been no clinical studies investigating the role of VK2 in the prevention or treatment of Alzheimer’s disease (AD), a debilitating disease for which currently there is no cure. In reviewing basic science research and clinical studies that have connected VK2 to factors involved in AD pathogenesis, we have found a growing body of evidence demonstrating that VK2 has the potential to slow the progression of AD and contribute to its prevention. In our review, we consider the antiapoptotic and antioxidant effects of VK2 and its impact on neuroinflammation, mitochondrial dysfunction, cognition, cardiovascular health, and comorbidities in AD. We also examine the link between dysbiosis and VK2 in the context of the microbiome’s role in AD pathogenesis. Our review is the first to consider the physiological roles of VK2 in the context of AD, and, given the recent shift in AD research toward nonpharmacological interventions, our findings emphasize the timeliness and need for clinical studies involving VK2.

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Section: Vitamin K2 and Alzheimer’s Diseasementioning

confidence: 59%

Vitamin K2 Holds Promise for Alzheimer’s Prevention and Treatment

Popescu¹,

German

2021

Nutrients

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“…Osteocalcin (OCN), also known as bone gamma-carboxyglutamic acid (Gla), is a circulating protein secreted by osteoblasts ( 62 , 63 ). It is initially synthesized with 95 amino acids and is subsequently cleaved to form a 46-amino acid mature peptide containing three gamma-carboxyl glutamate residues at sites 13, 17 and 20 ( 64 , 65 ).…”

Section: Bone-derived Hormones and Dnmentioning

confidence: 99%

Bone-kidney axis: A potential therapeutic target for diabetic nephropathy

et al. 2022

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Diabetic nephropathy (DN) is the leading cause of end-stage renal disease (ESRD). However, its pathogenesis remains unclear, and effective prevention and treatment strategies are lacking. Recently, organ-to-organ communication has become a new focus of studies on pathogenesis. Various organs or tissues (the liver, muscle and adipose tissue) secrete a series of proteins or peptides to regulate the homeostasis of distal organs in an endocrine manner. Bone, an important part of the body, can also secrete bone-derived proteins or peptides that act on distal organs. As an organ with high metabolism, the kidney is responsible for signal and material exchange with other organs at any time through circulation. In this review, we briefly discussed bone composition and changes in bone structure and function in DN and summarized the current status of bone-derived proteins and their role in the progression of DN. We speculated that the “bone-kidney axis” is a potential target for early diagnosis and treatment of DN.

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“…Many basic experimental studies have proved OCN engages in different stages of DM development and play a protective role through influencing adipose tissue metabolism, pancreatic function, and oxidative stress ( 74 ). In a clinical trial involving 75 middle-aged to aged Japanese without any anti-diabetic agent administration, it was observed that ucOCN is correlated with HbA1c and insulinogenic index (IGI) in the DM group, and ucOCN plays more vital roles in insulin secretion than in insulin sensitivity in patients with DM ( 75 ).…”

Section: Bone-derived Hormones and Dkdmentioning

confidence: 99%

The Emerging Role of Bone-Derived Hormones in Diabetes Mellitus and Diabetic Kidney Disease

Gu²,

Wang

et al. 2022

Front. Endocrinol.

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Diabetic kidney disease (DKD) causes the greatest proportion of end-stage renal disease (ESRD)–related mortality and has become a high concern in patients with diabetes mellitus (DM). Bone is considered an endocrine organ, playing an emerging role in regulating glucose and energy metabolism. Accumulating research has proven that bone-derived hormones are involved in glucose metabolism and the pathogenesis of DM complications, especially DKD. Furthermore, these hormones are considered to be promising predictors and prospective treatment targets for DM and DKD. In this review, we focused on bone-derived hormones, including fibroblast growth factor 23, osteocalcin, sclerostin, and lipocalin 2, and summarized their role in regulating glucose metabolism and DKD.

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Protective role of osteocalcin in diabetes pathogenesis

Cited by 12 publications

References 38 publications

Vitamin K2 Holds Promise for Alzheimer’s Prevention and Treatment

Vitamin K2 Holds Promise for Alzheimer’s Prevention and Treatment

Bone-kidney axis: A potential therapeutic target for diabetic nephropathy

The Emerging Role of Bone-Derived Hormones in Diabetes Mellitus and Diabetic Kidney Disease

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