Protective Role of Raw-Turmeric Rhizomes Against Nicotine-Induced Complications of Beedi (Indian Cigarette) Workers

Abstract

Introduction: The unscientific process of beedi (Indian smoking element) production under constant exposure of nicotine dust in India induces serious health disorders to the workers. Beedi produces more tar in smoke than cigarette due to lack of any filtering process. Sometimes active consumption of beedi and other tobacco products makes the users more vulnerable to cancer, respiratory diseases and cardiovascular disorders etc.Objective: The present study was designed to observe the protective effects of raw turmeric rhizomes on health conditions of the beedi workers who were exposed to nicotine dust for 8-10 hours daily for a long duration.Methods: General health checkup, blood glucose levels, lipid profiles and the hemogram profiles etc. of the workers from two beedi factories (Canning of South 24 Parganas District and Bankura of Bankura District, both in West Bengal, India) were conducted before and after the consumption of laboratory processed raw turmeric rhizomes (80 mg/kg body weight/day by chewing) for 8 weeks. Blood samples (5 ml) were collected from all the workers before and after the completion of the study and analyzed for estimation of different parameters. Results:The results showed significant improvement in the general health conditions of the factory workers who consumed raw-turmeric rhizomes. Significant improvement of blood pressure, blood glucose levels and lipid profiles and also improvement of creatinine, serum protein and SGOT/SGPT levels of the treated volunteers were noted. The results also showed improvement in the enzymes levels of SOD, GSH and GP X in the serum of rhizomes consumed workers. Conclusion:It is concluded that turmeric rhizomes are effective in the amelioration of nicotine-induced complications. It would be a better therapeutic supplement for the improvement of health for the workers who are compelled to work under nicotinic dust environment for a long time.

Potential amelioration of nicotine‐induced toxicity by nanocurcumin

“…Curcumin significantly ameliorates the toxicological effects and regulates the imbalance between cell survival and cell death caused by nicotine (Banerjee et al, 2012). It appears as a very active agent and a potential blocker against the nicotine-induced stress (Chattopadhyay, Tamang, & Kundu, 2015;Maiti et al, 2015) and inhibits the lipid peroxidation, lowers the biochemical marker enzymes and enhances the antioxidant status (Bandyopadhyaya et al, 2008;Kalpana & Menon, 2004). The protective and antioxidant effects of curcumin are superior to those of vitamins E and A (Ao, Chu, & Wang, 2014).…”