Protective role of rhapontin in experimental pulmonary fibrosis in vitro and in vivo

Tao, Lijun; Cao, Juan; Wei, Wencheng; Xie, Haifeng; Zhang, Mian

doi:10.1016/j.intimp.2017.03.020

Cited by 23 publications

(19 citation statements)

References 47 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…This is thought to occur in response to inflammation that facilitates natural repair of the endometrium (Gnainsky et al 2015). Through conditional mutagenesis studies or pharmacological activation, AMPK has been shown to reduce fibrosis and/or failure of scars to mature following injury in the liver (Ramezani-Moghadam et al 2015, Liang et al 2017, heart (Hermida et al 2013, Noppe et al 2014, lung (King et al 2012, Sato et al 2016, Tao et al 2017, kidney (Kim et al 2015, Thakur et al 2015, intestine (Cieslik et al 2017), peritoneum (Shin et al 2017, Zheng et al 2017, and adipose (Luo et al 2016). Our findings place AMPK at the center of the unique regenerative process within the endometrium that is essential for maintenance of fertility in the female.…”

Section: Discussionmentioning

confidence: 99%

A functional role for AMPK in female fertility and endometrial regeneration

et al. 2018

View full text Add to dashboard Cite

Adenosine monophosphate-activated protein kinase (AMPK) is a highly conserved heterotrimeric complex that acts as an intracellular energy sensor. Based on recent observations of AMPK expression in all structures of the female reproductive system, we hypothesized that AMPK is functionally required for maintaining fertility in the female. This hypothesis was tested by conditionally ablating the two catalytic alpha subunits of AMPK, Prkaa1 and Prkaa2, using Pgr-cre mice. After confirming the presence of PRKAA1, PRKAA2 and the active phospho-PRKAA1/2 in the gravid uterus by immunohistochemistry, control (Prkaa1/2 fl/fl ) and double conditional knockout mice (Prkaa1/2 d/d ) were placed into a six-month breeding trial. While the first litter size was comparable between Prkaa1/2 fl/fl and Prkaa1/2 d/d female mice (P = 0.8619), the size of all subsequent litters was dramatically reduced in Prkaa1/2 d/d female mice (P = 0.0015). All Prkaa1/2 d/d female mice experienced premature reproductive senescence or dystocia by the fourth parity. This phenotype manifested despite no difference in estrous cycle length, ovarian histology in young and old nulliparous or multiparous animals, mid-gestation serum progesterone levels or uterine expression of Esr1 or Pgr between Prkaa1/2 fl/fl and Prkaa1/2 d/d female mice suggesting that the hypothalamic–pituitary–ovary axis remained unaffected by PRKAA1/2 deficiency. However, an evaluation of uterine histology from multiparous animals identified extensive endometrial fibrosis and disorganized stromal-glandular architecture indicative of endometritis, a condition that causes subfertility or infertility in most mammals. Interestingly, Prkaa1/2 d/d female mice failed to undergo artificial decidualization. Collectively, these findings suggest that AMPK plays an essential role in endometrial regeneration following parturition and tissue remodeling that accompanies decidualization.

show abstract

Section: Discussionmentioning

confidence: 99%

A functional role for AMPK in female fertility and endometrial regeneration

et al. 2018

View full text Add to dashboard Cite

show abstract

“…Presently, the pharmacotherapy agent options are pirfenidone and nintedanib, which only received conditional suggestions in view of clinical effects, costs and safety profiles (Zhang et al, 2018a;Chen et al, 2018;Saito et al, 2019). Cortical hormone is also employed to treat PF, and prednisone acetate (PA) is the common selected drug for positive control studies in bleomycin-induced PF model (Ji et al, 2016;Tao et al, 2017;Zhang et al, 2018b;Chen et al, 2018). Traditional herbal medicines, with their efficacy and advantages have being investigated over years, have been considered to be potential candidates for treating IPF (Yao and Jiang, 2003).…”

Section: Introductionmentioning

confidence: 99%

Sodium Houttuyfonate Inhibits Bleomycin Induced Pulmonary Fibrosis in Mice

et al. 2021

View full text Add to dashboard Cite

Pulmonary fibrosis (PF) could severely disrupt the normal lung architecture and function with fatal consequences. Currently, there is no effective treatment for PF or idiopathic pulmonary fibrosis (IPF). The aim of this study was to investigate the effects of Sodium Houttuyfonate (SH) on bleomycin (BLM) induced PF mice model. Our results indicated that SH could attenuate BLM induced lung injury by reducing the inflammation, fibrogenesis and lung/body weight ratio. The proposed mechanisms for the protective effects of SH include: 1) improvement of pulmonary function in BLM mice, for instance, it can elevate the vital capacity (VC), increase the forced expiratory flow at 50% of forced vital capacity (FEF50) and improve other pulmonary function indices; 2) inhibition of collagen formation in BLM mice; 3) attenuation of the elevation of inflammatory cytokines, such as interleukin-1β (IL-1β), IL-6, and tumor necrosis factor-α (TNF-α), which are triggered by BLM administration; 4) reduction of the mRNA level and protein production of transforming growth factor-β1 (TGF-β1) in BLM mice. Furthermore, it was found that the protective effects of SH against BLM induced PF in mice was comparable to that of prednisone acetate (PA) tablets, a widely used drug for immunological diseases. Although Houttuynia Cordata Thunb has been widely used in China for lung infection and inflammation, the mechanism has not yet been fully elucidated. Our study provides the evidence that SH is an effective compound against pulmonary injury, irritation and fibrogenesis.

show abstract

“…Rhaponticin significantly reduced the development and expansion of pathological changes in an in vitro model of experimental pulmonary fibrosis, as well as in the bleomycin-induced pulmonary fibrosis in mice treated with daily doses of 25 mg and 100 mg/kg b.w. (Tao et al 2017). At a daily dose of 100 mg/kg b.w., rhaponticin was also found to reduce colonic epithelial dysfunction in a mouse experimental model of colitis; the action involved SIRT1-dependent signalling (Wei et al 2017).…”

Section: In Vivo Evidencementioning

confidence: 99%

Rhaponticin as an anti-inflammatory component of rhubarb: a minireview of the current state of the art and prospects for future research

Kołodziejczyk-Czepas

Czepas

2019

Phytochem Rev

View full text Add to dashboard Cite

Rhaponticin (3,3 0 ,5-trihydroxy-4 0methoxystilbene 3-O-b-D-glucoside; synonymrhapontin), is a stilbene compound, mainly found in various species of rhubarb (Rheum L.). The aglycone, rhapontigenin, is thought to be the biologically active form of rhaponticin. As a component of rhubarb, rhaponticin may be present in the human diet both in foods and dietary supplements. Although promising reports have been published on the various activities of rhaponticin (see: antioxidant, estrogenic, antithrombotic, anticancer and anti-inflammatory actions), no comprehensive review exists of its anti-inflammatory properties. Therefore, the aim of the present work is to summarize the existing evidence of the anti-inflammatory properties of rhaponticin and provide a prospective insight into research on this stilbenoid.

show abstract

Protective role of rhapontin in experimental pulmonary fibrosis in vitro and in vivo

Cited by 23 publications

References 47 publications

A functional role for AMPK in female fertility and endometrial regeneration

A functional role for AMPK in female fertility and endometrial regeneration

Sodium Houttuyfonate Inhibits Bleomycin Induced Pulmonary Fibrosis in Mice

Rhaponticin as an anti-inflammatory component of rhubarb: a minireview of the current state of the art and prospects for future research

Contact Info

Product

Resources

About