Protective Role of Some Antioxidants on Arsenic Toxicity in Male Mice: Physiological and Histopathological Perspectives

Amer, Sawsan M.; AL-Harbi, Mohammad S.; AL-Zahrani, Yousif A. A.

doi:10.4172/0974-8369.1000266

Biol Med (Aligarh)

2016

DOI: 10.4172/0974-8369.1000266

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Protective Role of Some Antioxidants on Arsenic Toxicity in Male Mice: Physiological and Histopathological Perspectives

Sawsan M. Amer¹,

Mohammad S. AL-Harbi²,

Yousif A. A. AL-Zahrani³

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Cited by 2 publications

References 22 publications

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Transplacental Hepato-Curative Potential of Garlic Against Sodium Arsenate Induced Oxidative Stress in Mice

Andleeb¹,

Aslam²,

Habib³

et al. 2020

THE JAPS

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Inorganic arsenic is a well-known toxicant and carcinogen. Millions of people in world are being affected by arsenic mainly through drinking water. Objectives: To evaluate toxic effects of sodium arsenate (Na3 AsO4) and assess protective role of garlic (Allium sativum) in minimizing its toxicological effects. Methodology: In this study, 20 pregnant female mice were divided into 4 groups. Group I (Control) was healthy control and Group II (Dose group) was orally administered with 50mg/kg of Na3 AsO4 on the "Gestation day 6" for consecutive 6 days. Group III (Dose+ Antidote group) mice were administered with 50mg/kg of Na3 AsO4 and garlic extract (30mg/kg) with a gap of one hour. Group IV (Antidote Group) was administered orally with garlic extract (30mg/kg). Results: Pregnant female mice were sacrificed at 18 th day of gestation, Na3 AsO4 affected weight, limbs, and size of the fetus. It also caused pyknosis, necrosis and increased sinusoidal space, fibrosis in both mother and fetal liver of mice. High mortality rate and pregnancies loss were observed in Group II. On the other hand, garlic showed strong antioxidant activity which neutralized oxidative stress condition in both mother and fetal liver of mice in Group III. Conclusion: Our findings indicated that Na3 AsO4 is a potential toxic metalloid that can cross placenta and garlic is equally effective in ameliorating these toxicities in mice.

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Transplacental Hepato-Curative Potential of Garlic Against Sodium Arsenate Induced Oxidative Stress in Mice

Andleeb¹,

Aslam²,

Habib³

et al. 2020

THE JAPS

View full text Add to dashboard Cite

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Selenium Nanoparticles Ameliorative Effect on Acetaminophen Hepatotoxicity in Male Mice

AL-Harbi¹,

Amer²

2017

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Selenium nanoparticles (SeNPs) have been widely used as anti-inflammatory and anti-toxic agent. The present study used Bacillus tequilensis for biosynthesizing SeNPs from sodium selenite (Na 2 SeO 3 ) and investigated its ameliorative effects on acetaminophen (APAP) hepatotoxicity in male mice. The results indicated that Alanine transaminase (ALT), aspartate aminotransferase (AST) and alkaline phosphatase (ALP) significantly elevated in mice treated with APAP, while other liver markers (total proteins and albumin) did not change. SeNPs either alone or in combination with APAP showed ameliorative effects on liver enzymes to some extents where their activities decreased to be insignificant with those of normal group. A slight variation was shown in total antioxidant capacity (TAC). Histopathologically, the hepatocytes of the mice treated with APAP showed cloudy swelling and vacuolar degeneration, while those treated with SeNPs or both SeNPs and APAP appeared more or less histologically normal. In conclusion, SeNPs can be used to improve or replace today's therapies of APAP hepatotoxicity.

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Protective Role of Some Antioxidants on Arsenic Toxicity in Male Mice: Physiological and Histopathological Perspectives

Cited by 2 publications

References 22 publications

Transplacental Hepato-Curative Potential of Garlic Against Sodium Arsenate Induced Oxidative Stress in Mice

Transplacental Hepato-Curative Potential of Garlic Against Sodium Arsenate Induced Oxidative Stress in Mice

Selenium Nanoparticles Ameliorative Effect on Acetaminophen Hepatotoxicity in Male Mice

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