Protective Role of Spirulina platensis against Acute Deltamethrin-Induced Toxicity in Rats

Abdel-Daim, Mohamed M.; Abuzead, Said M. M.; Halawa, Safaa M.

doi:10.1371/journal.pone.0072991

Cited by 224 publications

(114 citation statements)

References 56 publications

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“…[1345] It is also possible that the slight degeneration of hepatocytes in the ATZ-treated rats and/or mild periportal cellular infiltration by mononuclear cells in the ATZ + Q5-treated rats were sufficient to induce the release of the serum markers from the liver into the systemic circulation which was completely prevented on co-administration of Q10. The susceptibility of renal tissues to the toxic effects of noxious chemicals can be attributed in part to the differences in the anatomic and physiologic features of this organ.…”

Section: Resultsmentioning

confidence: 99%

Protective effect of quercetin on atrazine-induced oxidative stress in the Liver, Kidney, Brain, and Heart of adult wistar rats

Abarikwu¹

2014

Toxicol Int

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Background:The conflicting roles of quercetin against tissue pathologies associated with oxidative stress are known.Objective:To evaluate the effect of quercetin at doses of 5 mg/kg (Q5) or 10 mg/kg (Q10) against atrazine (120 mg/kg, ATZ)-induced oxidative stress in various tissues of rats.Materials and Methods:Adult male albino Wistar rats were administered ATZ, Q5, and Q10 alone or in combination for 16 days. At the end of the 16th day, the animals were sacrificed by cervical dislocation; and the blood, heart, brain, kidney and liver were collected and used for biochemical determinations and histopathological examination.Results:Q10 but not Q5 attenuated ATZ-induced increase in the levels of serum enzyme markers sorbitol dehydrogenase (SDH), acid phosphatase (ACP), alkaline phosphatase (ALP), and aspartate aminotransferase (AST). The heart was less susceptible to ATZ-induced oxidative stress than the liver, kidney, and brain of treated animals, and there were tendencies for synergistic effects in the heart and liver of Q5 + ATZ-treated rats. Oxidative stress-induced by ATZ in terms of increased lipid peroxidation level and superoxide dismutase (SOD) activity was decreased in the brain of the Q5 + ATZ-treated rats but not that of the Q10 + ATZ-treated rats. Conversely, histopathological changes and oxidative stress-induced by ATZ in terms of elevated lipid peroxidation level, decreased SOD, and catalase (CAT) activities were prevented in the kidney and liver of the Q10 + ATZ-treated rats but not that of the Q5 + ATZ-treated rats.Conclusion:Quercetin at the investigated doses and especially the low dose may not protect against ATZ-induced oxidative stress in rat tissues in an overall sense.

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Section: Resultsmentioning

confidence: 99%

Protective effect of quercetin on atrazine-induced oxidative stress in the Liver, Kidney, Brain, and Heart of adult wistar rats

Abarikwu¹

2014

Toxicol Int

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“…C-PC has also been shown to stimulate the immune system and exhibit hepatoprotective, antiplatelet, and neuroprotective activities [8,9,10]. It is believed that the various health benefits of spirulina are derived from oxidative stress reduction [11,12], and β-carotene and C-PC are important contributors to this effect [13]. …”

Section: Introductionmentioning

confidence: 99%

Two Classes of Pigments, Carotenoids and C-Phycocyanin, in Spirulina Powder and Their Antioxidant Activities

et al. 2018

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Arthrospira platensis is the widely available source of spirulina that contains distinctive natural pigments, including carotenoids and C-phycocyanin (C-PC). In this study, the major carotenoid and C-PC contents were determined in seven commercially available spirulina powder products and laboratory-prepared A. platensis trichomes (AP-1) by an LC-DAD method and UV-Visible spectrometry, respectively. The correlation of these two pigment content levels with Hunter color coordinates and antioxidant activity was also evaluated. The L* value failed to show a significant correlation with pigment content, but a positive correlation was observed between a* values and the contents of total carotenoid and C-PC. As b* values decreased, the chlorophyll a and C-PC contents increased. AP-1 exhibited the highest content of total carotenoids, chlorophyll a and C-PC, and antioxidant activities among the samples. This observation could be related to degradation of these pigments during the mass production process. The carotenoid profiles suggested that the commercial spirulina powders originated from two different sources, A. platensis and A. maxima. Total carotenoid and C-PC content exhibited positive significant correlations with antioxidant activities measured by 1,1-diphenyl-2-picrylhydrazyl (DPPH) and 2,2′-azino-bis(3-ethylbenzothiazoline-6-sulphonic acid) (ABTS) assays. These results provide a strong scientific foundation for the establishment of standards for the commercial distribution of quality spirulina products.

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“…The cells overcome oxidative stress by either removal of the damaged nucleotides and products of the lipid peroxidation or directly scavenging free radicals via endogenous enzymatic and non-enzymatic antioxidants (Madkour and Abdel-Daim 2013;Abdel-Daim et al 2013;Azab et al 2013).…”

Section: Introductionmentioning

confidence: 99%

Synergistic protective role of ceftriaxone and ascorbic acid against subacute diazinon-induced nephrotoxicity in rats

Abdel-Daim

2014

Cytotechnology

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Diazinon (DZN) is a synthetic organophosphrus acaricide and insecticide widely used for veterinary and agricultural purposes. However, its animal and human exposure leads to nephrotoxicity. Our experimental objective was to evaluate protective effects of ceftriaxone and/or ascorbic acid-vitamin C against DZN-induced renal injury in male Wistar albino rats. DZN-treated animals revealed significant elevation in serum biochemical parameters related to renal injury: urea, uric acid and creatinine. DZN intoxication significantly increased renal lipid peroxidation, and significant inhibition in antioxidant biomarkers including, reduced glutathione, glutathione peroxidase, superoxide dismutase, catalase and total antioxidant capacity. In addition, DZN significantly reduced serum acetylcholinestrase level. Moreover, It induced serum and kidney tumor necrosis factor-a level. Both ceftriaxone and vitamin C protect against DZN-induced serum as well as renal tissue biochemical parameters when used alone or in combination along with DZN-intoxication. Furthermore, both ceftriaxone and vitamin C produced synergetic nephroprotective and antioxidant effects. Therefore, it could be concluded that ceftriaxone and/or vitamin C administration are able to minimize the toxic effects of DZN by its free radical-scavenging and potent antioxidant activity.

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Protective Role of Spirulina platensis against Acute Deltamethrin-Induced Toxicity in Rats

Cited by 224 publications

References 56 publications

Protective effect of quercetin on atrazine-induced oxidative stress in the Liver, Kidney, Brain, and Heart of adult wistar rats

Protective effect of quercetin on atrazine-induced oxidative stress in the Liver, Kidney, Brain, and Heart of adult wistar rats

Two Classes of Pigments, Carotenoids and C-Phycocyanin, in Spirulina Powder and Their Antioxidant Activities

Synergistic protective role of ceftriaxone and ascorbic acid against subacute diazinon-induced nephrotoxicity in rats

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