Protective role of vitamin D against radiation hazards in rats fed on high fat diet

Elmonem, Hanan A. Abd; Mater, Salwa N.A.; Eldeighdye, Shaimaa M.

doi:10.1016/j.jrras.2022.04.006

Cited by 2 publications

(1 citation statement)

References 40 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Furthermore, whole-body UVC irradiation revealed hyperlipidemia, as represented by a significant elevation in the serum total cholesterol and triglyceride levels upon increasing the UVC irradiation doses compared to the control rats. Radiation-induced hyperlipidemia may be attributed to the alterations in hepatic lipid metabolism and may result from radiation's indirect effect on the release of several inflammatory mediators [56,57]. Various inflammatory mediators consist of modified lipids, such as oxidized LDL-cholesterol.…”

Section: Discussionmentioning

confidence: 99%

The Prophylactic Effect of Vitamin C and Vitamin B12 against Ultraviolet-C-Induced Hepatotoxicity in Male Rats

et al. 2023

View full text Add to dashboard Cite

Ultraviolet C (UVC) devices are an effective means of disinfecting surfaces and protecting medical tools against various microbes, including coronavirus. Overexposure to UVC can induce oxidative stress, damage the genetic material, and harm biological systems. This study investigated the prophylactic efficacy of vitamin C and B12 against hepatotoxicity in UVC-intoxicated rats. Rats were irradiated with UVC (725.76, 967.68, and 1048.36 J/cm2) for 2 weeks. The rats were pretreated with the aforementioned antioxidants for two months before UVC irradiation. The prophylactic effect of vitamins against UVC hepatotoxicity was evaluated by monitoring the alteration of liver enzyme activities, antioxidant status, apoptotic and inflammatory markers, DNA fragmentation, and histological and ultrastructural alterations. Rats exposed to UVC showed a significant increase in liver enzymes, oxidant–antioxidant balance disruption, and increased hepatic inflammatory markers (TNF-α, IL-1β, iNOS, and IDO-1). Additionally, obvious over-expression of activated caspase-3 protein and DNA fragmentation were detected. Histological and ultrastructural examinations verified the biochemical findings. Co-treatment with vitamins ameliorated the deviated parameters to variable degrees. In conclusion, vitamin C could alleviate UVC-induced hepatotoxicity more than vitamin B12 by diminishing oxidative stress, inflammation, and DNA damage. This study could provide a reference for the clinical practice of vitamin C and B12 as radioprotective for workers in UVC disinfectant areas.

show abstract

Section: Discussionmentioning

confidence: 99%