Protective role of zinc in liver damage in experimental diabetes demonstrated via different biochemical parameters

Abstract

Diabetes mellitus is a serious worldwide metabolic disease, which is accompanied by hyperglycaemia and affects all organs and body system. Zinc (Zn) is a basic cofactor for many enzymes, which also plays an important role in stabilising the structure of insulin. Liver is the most important target organ after pancreas in diabetic complications. In this study, we aimed to investigate the protective role of Zn in liver damage in streptozotocin (STZ)‐induced diabetes mellitus. There are four experimental groups of female Swiss albino rats: group I: control; group II: control + ZnSO4; group III: STZ‐induced diabetic animals and group IV: STZ‐diabetic + ZnSO4. To induce diabetes, STZ was injected intraperitoneally (65 mg/kg). ZnSO4 (100 mg/kg) was given daily to groups II and IV by gavage for 60 days. At the end of the experiment, rats were killed under anaesthesia and liver tissues were collected. In the diabetic group, hexose, hexosamine, fucose, sialic acid levels, arginase, adenosine deaminase, tissue factor activities and protein carbonyl levels increased, whereas catalase, superoxide dismutase, glutathione‐S‐transferase, glutathione peroxidase, glutathione reductase and Na+/K+‐ATPase activities decreased. The administration of Zn to the diabetic group reversed all the negative effects/activities. According to these results, we can suggest that Zn has a protective role against STZ‐induced diabetic liver damage.

Effects of Scorzonera cinerea on Immune System and Hematological Parameters in Short-Term Hyperglycemia

“…ADA activity increased in both tissues of the diabetic group (Figure 1). Current findings are supported by many studies that were found a significant elevation in ADA activity in tissues of STZ-induced diabetic rats (28)(29)(30). It has been stated that in type 2 diabetes, ADA activities are mainly raised which has a positive correlation with glycemic parameters (26).…”

Investigation of the anti-hyperglycemic and antioxidant effects of wheat bread supplemented with onion peel extract and onion powder in diabetic rats

“…In the alloxan-induced diabetic rats, weak antioxidant enzymatic activities, elevated lipid peroxidation, and lowered nonenzymatic antioxidant levels were reported in previous studies [68][69][70][71]. To protect the body against ROS-mediated oxidative damage, antioxidant enzymes are released including superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GPx), and glutathione reductase (GR) [72].…”

Effect of Antiepileptic Drug Sodium Valproate on Stomach Tissue Glycoproteins: The Protective Role of Moringa Extract

“…34 Similarly, vitamin U mitigate either amiodarone or D-galactosamine-induced hepatotoxicity, oxidative damage, as well as distortion of glycan levels. 35 Sacan et al 36 (2021) and Turkyilmaz et al 37 (2021) have demonstrated that antioxidant and antiinflammatory elements such as zinc could protect against cellular damage induced by streptozotocin. It also prevented oxidative stress and maintained normal levels of glycoconjugates.…”