Protective roles of crude and fractions of A. senegalensise carpel against alloxan-induced hyperglycemia and hyperlipidemia in rats

Maikai, Sophia Shekwoyan; Raji, Ramat Onyeneoyiza; Muhammad, Hadiza Lami; Abubakar, Abdulkadir

doi:10.1007/s00580-019-03063-1

Cited by 2 publications

(2 citation statements)

References 21 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The methanol crude extraction, and n-Hexane and ethylacetate fractionations were conducted as described in our previous studies [15,16]. Briefly, six hundred grams (600 g) of powdered Gymnema sylvestre plant sample was extracted exhaustively extracted with 2.5 liters of methanol.…”

Section: Sample Extractionmentioning

confidence: 99%

“…Due to limitation and adverse effects of available antidiabetic drugs, the disease is currently becoming difficult to manage [5]. With increasing incidence of BIOMED Natural and Applied Science 2021;1 (2): [11][12][13][14][15][16][17][18][19][20][21][22][23] diabetes mellitus among rural population, there is a clear need for development of inexpensive agents that would be used for the management of diabetes [6] Herbs are alternative medicines for treatment of various diseases due to their acceptability, effectiveness, affordability, assumed safety and low cost [7]. Traditional medicine existed from ancient times, and is estimated by World Health Organization to be in use by 80 % of the population in most of the developing countries [8].…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Ameliorative effect of crude and solvent partitioned fractions of Gymnema sylvestre in alloxan-induced hyperglycemic and dyslipidemic Rattus norvegicus

Raji¹,

Muhammad²,

Makun³

et al. 2021

BIOMED nat. appl. sci.

Self Cite

View full text Add to dashboard Cite

The present study aims to evaluate the ameliorative effect of crude and solvent partitioned fractions of Gymnema sylvestre in alloxan-induced hyperglycemic and dyslipidemic rats. The extract and fractions of Gymnema sylvestre were administered to alloxan (120 mg/kg) induced diabetic rats at doses of 100, 300, and 600 mg/kg. Metformin (100 mg/kg) was used as the reference drug. All treatments were administered daily for 14 days through the oral route. Effects of the treatments on blood glucose levels, body weight, and serum lipid profiles were monitored. The results revealed that all the extracts and fractions were able to reduce the blood glucose levels and improved the body weight of diabetic rats, with more pronounced effects at the treatment of 300 mg/kg of crude methanol and ethyl acetate fraction. The blood glucose of diabetic untreated rats continued to increase up to the time of euthanization. There were significant reductions (p<0.05) in the levels of serum total cholesterol, triglyceride, and low-density lipoprotein cholesterol (LDL-C) of all the treated groups when compared to the diabetic untreated. However, a significant (p<0.05) decrease in the serum concentration of highdensity lipoprotein- cholesterol (HDL- C) was observed in the diabetic untreated rats when compared to the HDL-C levels in the treated rats. The ameliorative effect of the crude extract and the partitioned fractions on the diabetic induced alterations in serum lipid profile occurs in a significant (p<0.05) dosedependent manner. In conclusion, G. sylvestre extracts possess hypoglycaemic effects and attenuated diabetic induced dyslipidemia in rats

show abstract

Section: Sample Extractionmentioning

confidence: 99%