Protein adducts with lipid peroxidation products in patients with psoriasis

Wroński, Adam; Gęgotek, Agnieszka; Skrzydlewska, Elżbieta

doi:10.1016/j.redox.2023.102729

Cited by 6 publications

(5 citation statements)

References 107 publications

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“…LOX is reported to be essential for intracellular ROS production mediated by pro-inammatory stimuli including LPS. 43 The results of this study demonstrate that the gradient increase in 5-LOX expression post-stimulation suggests that LOX-generated arachidonic acid (AA) metabolites namely leukotrienes (LT) induce ROS generation by stimulating NOX. Among the reported ROS, O 2 c − is a key redox signaling molecule generated by NOX enzymes.…”

Section: Discussionmentioning

confidence: 84%

NADPH oxidase-dependent free radical generation and protein adduct formation in neutrophils

Manoharan,

Zachová,

Buzáš

et al. 2024

RSC Adv.

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Section: Discussionmentioning

confidence: 84%

NADPH oxidase-dependent free radical generation and protein adduct formation in neutrophils

Manoharan,

Zachová,

Buzáš

et al. 2024

RSC Adv.

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“…NO 2 -OA also downregulated the production of psoriasis-dependent inflammatory cytokines in the skin, including IL-1β, IL-23, IL-6, and IL-17 (Wroński et al 2023). In a previous study, NO 2 -FAs suppressed allergic contact dermatitis (ACD) in mice, and subcutaneous injection of NO 2 -OA also decreased IL-1β and IL-6, which are essential promoters of Th17 cell differentiation involved in ACD.…”

Section: Other Inflammation Diseasesmentioning

confidence: 82%

Nitro-fatty acids: mechanisms of action, roles in metabolic diseases, and therapeutics

Ni,

Tan,

et al. 2024

Curr Med

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Nitro-fatty acids (NO2-FAs) are a class of bioactive lipids that mediate metabolic, anti-oxidative stress, anti-inflammatory, and other signaling actions. Endogenously, NO2-FAs are derived from the non-enzymatic reactions of unsaturated fatty acids with reactive nitrogen species. The electrophilic properties of the nitro group results in NO2-FAs being able to undergo rapid and reversible reactions with biological nucleophiles, such as cysteine and histidine, thus supporting post-translational modifications of proteins. The reactions of NO2-FAs with biological nucleophiles regulate a range of key signaling pathways involved in gene expression responses, enzyme activity, and cellular processes. In disease animal models, NO2-FAs are produced under conditions of inflammation and oxidative stress and play a protective role in a variety of metabolic diseases, which have been associated with anti-atherosclerosis, blood-pressure lowering, and are involved in the regulation of glycolipid metabolism and insulin resistance. Based on these, more clinical studies might find a correlation between NO2-FAs levels and pathophysiology in patients with metabolic diseases. Importantly, NO2-FAs therapeutics are effective in clinical trials. In addition, dietary supplementation with nitrates and unsaturated fatty acids can endogenously increase NO2-FAs levels in mice and humans. These findings support dietary approaches that increase the endogenous levels of NO2-FAs might potentially reduce the risk of metabolic diseases. To identify the specific mechanism of action and therapeutic potential of NO2-FAs, we have summarized the main mechanisms of action of NO2-FAs in metabolic disease progression to provide insights for the development of new therapeutics for metabolic diseases.

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“…This differs from conditions like psoriasis, where hyperkeratosis results from increased basal layer proliferation driven by an underlying immune-related pathology [14]. Hyperkeratosis and its differential diagnoses encompass a wide range of conditions, including palmoplantar keratodermas, ichthyoses, psoriasis, atopic dermatitis, calluses and corns, seborrheic keratosis, nonmelanoma skin cancers, and others [67][68][69][70][71][72][73][74][75].…”

Section: Skin Conditions/disorders and Related Histological Findings ...mentioning

confidence: 99%

“…Disorders of keratin-associated proteins is a group that encompasses more prevalent conditions, including ichthyosis vulgaris, lamellar ichthyosis, pemphigus, psoriasis, and Darier disease [ 5 , 70 , 78 , 79 , 80 ]. Diseases from the group “ichthyoses” share the feature of dry, rough skin with scaling.…”

Section: Skin Conditions/disorders and Related Histological Findings ...mentioning

confidence: 99%

“…Psoriasis, a highly prevalent condition driven by immunological and genetic factors, manifests with hyperkeratotic, erythematous plaques covered by silvery scales, which are commonly distributed on the scalp, elbows, and knees [ 70 , 80 ]. Darier’s disease develops due to a mutation in the gene encoding the intracellular calcium pump (ATP2A2) and is inherited in an autosomal dominant fashion.…”

Section: Skin Conditions/disorders and Related Histological Findings ...mentioning

confidence: 99%

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Key Factors in the Complex and Coordinated Network of Skin Keratinization: Their Significance and Involvement in Common Skin Conditions

Pondeljak,

Lugović-Mihić,

Tomić

et al. 2023

IJMS

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The epidermis serves many vital roles, including protecting the body from external influences and healing eventual injuries. It is maintained by an incredibly complex and perfectly coordinated keratinization process. In this process, desquamation is essential for the differentiation of epidermal basal progenitor cells into enucleated corneocytes, which subsequently desquamate through programmed death. Numerous factors control keratinocyte differentiation: epidermal growth factor, transforming growth factor-α, keratinocyte growth factor, interleukins IL-1-β and IL-6, elevated vitamin A levels, and changes in Ca2+ concentration. The backbone of the keratinocyte transformation process from mitotically active basal cells into fully differentiated, enucleated corneocytes is the expression of specific proteins and the creation of a Ca2+ and pH gradient at precise locations within the epidermis. Skin keratinization disorders (histologically characterized predominantly by dyskeratosis, parakeratosis, and hyperkeratosis) may be categorized into three groups: defects in the α-helical rod pattern, defects outside the α-helical rod domain, and disorders of keratin-associated proteins. Understanding the process of keratinization is essential for the pathogenesis of many dermatological diseases because improper desquamation and epidermopoiesis/keratinization (due to genetic mutations of factors or due to immune pathological processes) can lead to various conditions (ichthyoses, palmoplantar keratodermas, psoriasis, pityriasis rubra pilaris, epidermolytic hyperkeratosis, and others).

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Protein adducts with lipid peroxidation products in patients with psoriasis

Cited by 6 publications

References 107 publications

NADPH oxidase-dependent free radical generation and protein adduct formation in neutrophils

NADPH oxidase-dependent free radical generation and protein adduct formation in neutrophils

Nitro-fatty acids: mechanisms of action, roles in metabolic diseases, and therapeutics

Key Factors in the Complex and Coordinated Network of Skin Keratinization: Their Significance and Involvement in Common Skin Conditions

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