Protein adsorption and cell adhesion controlled by the surface chemistry of binary perfluoroalkyl/oligo(ethylene glycol) self-assembled monolayers

Li, Shanshan; Yang, Dingyun; Tu, Haiyang; Deng, Hongtao; Du, Dan; Zhang, Aidong

doi:10.1016/j.jcis.2013.04.003

Cited by 25 publications

(14 citation statements)

References 51 publications

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“…Surface properties have an important impact on not only cell viability, but also cell adhesion and proliferation [36,37]. The adhered HLECs on the surface were photographed with an inverted fluorescence microscope after FDA staining, and the results are shown in Fig.…”

Section: Cytotoxicity Of the Materials Surfacesmentioning

confidence: 99%

Hydrophobic modification of polymethyl methacrylate as intraocular lenses material to improve the cytocompatibility

Wang

Lin

Shen³

et al. 2014

Journal of Colloid and Interface Science

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Section: Cytotoxicity Of the Materials Surfacesmentioning

confidence: 99%

Hydrophobic modification of polymethyl methacrylate as intraocular lenses material to improve the cytocompatibility

Wang

Lin

Shen³

et al. 2014

Journal of Colloid and Interface Science

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“…Coatings based on oligo(ethylene glycol) (oEG), polysaccharides, zwitterionic compounds or perfluoroalkyls are some examples. 29,30,31,32,33,34 As oEGs are nontoxic and nonimmunogenic, they are widely used in medical applications. 35,36,37,38 The dominant way through which proteins adhere to surfaces is by hydrophobic effect.…”

mentioning

confidence: 99%

Grafting of Oligo(ethylene glycol)-Functionalized Calix[4]arene-Tetradiazonium Salts for Antifouling Germanium and Gold Surfaces

et al. 2018

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Biosensors that can determine protein concentration and structure are highly desired for biomedical applications. For the development of such biosensors, the use of Fourier transform infrared (FTIR) spectroscopy with the attenuated internal total reflection (ATR) configuration is particularly attractive, but it requires appropriate surface functionalization of the ATR optical element. Indeed, the surface has to specifically interact with a target protein in close contact with the optical element and must display antifouling properties to prevent nonspecific adsorption of other proteins. Here, we report robust monolayers of calix[4]arenes bearing oligo(ethylene glycol) (oEG) chains, which were grafted on germanium and gold surfaces via their tetradiazonium salts. The formation of monolayers of oEGylated calix[4]arenes was confirmed by AFM, IR, and contact angle measurements. The antifouling properties of these modified surfaces were studied by ATR-FTIR spectroscopy and fluorescence microscopy, and the nonspecific absorption of bovine serum albumin was found to be reduced by 85% compared to that of unmodified germanium. In other words, the organic coating by oEGylated calix[4]arenes provides remarkable antifouling properties, opening the way for the design of germanium- or gold-based biosensors.

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“…This was the result from differential protein adsorption between modified and unmodified substrate areas, which can preferentially promote or resist cell attachment [296]. Similar studies were conducted later on using different SAMs, materials, preparation methods and cell types [297][298][299][300].…”

Section: A 2d Modelsmentioning

confidence: 83%

Molecular bionics – engineering biomaterials at the molecular level using biological principles

et al. 2019

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Life and biological units are the result of the supramolecular arrangement of many different types of molecules, all of them combined with exquisite precision to achieve specific functions. Taking inspiration from the design principles of nature allows engineering more efficient and compatible biomaterials. Indeed, bionic (from bion-, unit of life and -ic, like) materials have gained increasing attention in the last decades due to their ability to mimic some of the characteristics of nature systems, such as dynamism, selectivity, or signalling. However, there are still many challenges when it comes to their interaction with the human body, which hinder their further clinical development. Here we review some of the recent progress in the field of molecular bionics with the final aim of providing with design rules to ensure their stability in biological media as well as to engineer novel functionalities which enable navigating the human body.

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Protein adsorption and cell adhesion controlled by the surface chemistry of binary perfluoroalkyl/oligo(ethylene glycol) self-assembled monolayers

Cited by 25 publications

References 51 publications

Hydrophobic modification of polymethyl methacrylate as intraocular lenses material to improve the cytocompatibility

Hydrophobic modification of polymethyl methacrylate as intraocular lenses material to improve the cytocompatibility

Grafting of Oligo(ethylene glycol)-Functionalized Calix[4]arene-Tetradiazonium Salts for Antifouling Germanium and Gold Surfaces

Molecular bionics – engineering biomaterials at the molecular level using biological principles

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