1968
DOI: 10.1093/jn/95.4.569
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Protein and Nucleic Acid Metabolism in the Testes of Zinc-deficient Rats

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Cited by 61 publications
(16 citation statements)
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“…The zinc deficiency observed in the present study appears, therefore, to be related to the lipid accumulation observed by Lacy (1967) and Kochar & Harrison (1971). Macapinlac, Pearson, Barney & Darby (1968) reported that an increased catabolism of protein and RNA occurs in the testes of zinc-deficient rats rather than a decrease in their synthesis. Since RNA (Gupta & Bawa, 1970, 1974b and 65Zn decline in irradiated testes, the possibility of catabolism of RNA due to zinc deficiency cannot be excluded.…”
Section: Methodssupporting
confidence: 69%
“…The zinc deficiency observed in the present study appears, therefore, to be related to the lipid accumulation observed by Lacy (1967) and Kochar & Harrison (1971). Macapinlac, Pearson, Barney & Darby (1968) reported that an increased catabolism of protein and RNA occurs in the testes of zinc-deficient rats rather than a decrease in their synthesis. Since RNA (Gupta & Bawa, 1970, 1974b and 65Zn decline in irradiated testes, the possibility of catabolism of RNA due to zinc deficiency cannot be excluded.…”
Section: Methodssupporting
confidence: 69%
“…Depasquale-Jardieu & Fraker (1979) reported that Zn deficiency caused an increase in plasma corticosterone level which in turn destroyed thymic 1ymphocytes.The splenomegaly observed (Gupta, 1984) might have also resulted in some degree of lymphocytopenia. Lymphocytopenia due to Zn deficiency has also been reported in rats (Macapinlac et al 1966). In group ZnR, the serum Zn concentration increased rapidly within 3 d of repletion.…”
Section: Smentioning
confidence: 82%
“…However, liver ribosomal RNA was reduced 33 % following prolonged treatment of rats with cortisone with only slight changes in synthetic and degradation rates (Loeb and Tolentino 1970). Macapinlac et al (1968) showed reductions of RNA in testicular tissues without altered synthesis in the testicular tissues of zinc-deficient rats. The suggestion of these last authors that RNA was being catabolized at an increased rate in such animals was supported by Somers and Underwood (1969).…”
Section: Discussionmentioning
confidence: 98%