Protein- and tryptophan-restricted diets induce changes in rat gonadal hormone levels

Angel-Meza, A.R. Del; Feria‐Velasco, Alfredo; Ontiveros-Martı́nez, Leticia; Gallardo, Lourdes; González-Burgos, Ignacio; Beas‐Zárate, Carlos

doi:10.1016/s0955-2863(00)00127-3

Cited by 3 publications

(2 citation statements)

References 44 publications

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“…For instance, serotonin affects gonadotropin release, and dietary tryptophan restriction in pubertal rats significantly reduces serotonin, serum LH, and progesterone levels. 116 Recent studies have found that during the critical stages of meiotic resumption in porcine cumulus cells (GV, GVBD, and MII stages), levels of key indole compounds produced from tryptophan metabolism significantly decrease. 117 This is essential for oocyte maturation because high concentrations of indole compounds (such as melatonin) might impede oocyte maturation.…”

Section: The Role Of Tryptophan Metabolism In Follicle Developmentmentioning

confidence: 99%

“…These metabolites can act on the brain and follicular granulosa cells, influencing the release of gonadotropins and sex hormones. For instance, serotonin affects gonadotropin release, and dietary tryptophan restriction in pubertal rats significantly reduces serotonin, serum LH, and progesterone levels 116 . Recent studies have found that during the critical stages of meiotic resumption in porcine cumulus cells (GV, GVBD, and MII stages), levels of key indole compounds produced from tryptophan metabolism significantly decrease 117 .…”

Section: Tryptophan For Nad+ Biosynthesis: Balancing Elevated Nad+ Le...mentioning

confidence: 99%

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Exploring nicotinamide adenine dinucleotide precursors across biosynthesis pathways: Unraveling their role in the ovary

Ren,

Zhang,

Chen

et al. 2024

The FASEB Journal

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Natural Nicotinamide Adenine Dinucleotide (NAD+) precursors have attracted much attention due to their positive effects in promoting ovarian health. However, their target tissue, synthesis efficiency, advantages, and disadvantages are still unclear. This review summarizes the distribution of NAD+ at the tissue, cellular and subcellular levels, discusses its biosynthetic pathways and the latest findings in ovary, include: (1) NAD+ plays distinct roles both intracellularly and extracellularly, adapting its distribution in response to requirements. (2) Different precursors differs in target tissues, synthetic efficiency, biological utilization, and adverse effects. Importantly: tryptophan is primarily utilized in the liver and kidneys, posing metabolic risks in excess; nicotinamide (NAM) is indispensable for maintaining NAD+ levels; nicotinic acid (NA) constructs a crucial bridge between intestinal microbiota and the host with diverse functions; nicotinamide riboside (NR) and nicotinamide mononucleotide (NMN) increase NAD+ systemically and can be influenced by delivery route, tissue specificity, and transport efficiency. (3) The biosynthetic pathways of NAD+ are intricately intertwined. They provide multiple sources and techniques for NAD+ synthesis, thereby reducing the dependence on a single molecule to maintain cellular NAD+ levels. However, an excess of a specific precursor potentially influencing other pathways. In addition, Protein expression analysis suggest that ovarian tissues may preferentially utilize NAM and NMN. These findings summarize the specific roles and potential of NAD+ precursors in enhancing ovarian health. Future research should delve into the molecular mechanisms and intervention strategies of different precursors, aiming to achieve personalized prevention or treatment of ovarian diseases, and reveal their clinical application value.

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Section: The Role Of Tryptophan Metabolism In Follicle Developmentmentioning

confidence: 99%

Section: Tryptophan For Nad+ Biosynthesis: Balancing Elevated Nad+ Le...mentioning

confidence: 99%

Exploring nicotinamide adenine dinucleotide precursors across biosynthesis pathways: Unraveling their role in the ovary

Ren,

Zhang,

Chen

et al. 2024

The FASEB Journal

View full text Add to dashboard Cite

show abstract

Reproductive and metabolic responses of desert adapted common spiny male mice (Acomys cahirinus) to vasopressin treatment

Bukovetzky

Fares

Schwimmer

et al. 2012

Comparative Biochemistry and Physiology Part A: Molecular &

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Cerebral serotonin depletion induces egocentric learning improvement in developing rats

Olvera‐Cortés¹,

Barajas-Pérez²,

Morales‐Villagrán³

et al. 2001

Neuroscience Letters

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Protein- and tryptophan-restricted diets induce changes in rat gonadal hormone levels

Cited by 3 publications

References 44 publications

Exploring nicotinamide adenine dinucleotide precursors across biosynthesis pathways: Unraveling their role in the ovary

Exploring nicotinamide adenine dinucleotide precursors across biosynthesis pathways: Unraveling their role in the ovary

Reproductive and metabolic responses of desert adapted common spiny male mice (Acomys cahirinus) to vasopressin treatment

Cerebral serotonin depletion induces egocentric learning improvement in developing rats

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