Protein arginine methyltransferases in renal development, injury, repair, and fibrosis

Abstract

Protein arginine methyltransferases (PRMTs) methylate a range of histone and non-histone substrates and participate in multiple biological processes by regulating gene transcription and post-translational modifications. To date, most studies on PRMTs have focused on their roles in tumors and in the physiological and pathological conditions of other organs. Emerging evidence indicates that PRMTs are expressed in the kidney and contribute to renal development, injury, repair, and fibrosis. In this review, we summarize the role and the mechanisms of PRMTs in regulating these renal processes and provide a perspective for future clinical applications.

Levels of asymmetric dimethylarginine in plasma and aqueous humor: a key risk factor for the severity of fibrovascular proliferation in proliferative diabetic retinopathy

“…Research has shown that arginine metabolism promotes skeletal muscle and cardiac fibrosis in patients with muscular dystrophy ( 11 ).Additionally, arginine methylation plays a role in regulating epithelial-mesenchymal transition ( 12 ). Protein arginine methyltransferase has been shown to promote the progression of fibrosis in conditions such as diabetic nephropathy, idiopathic pulmonary fibrosis, and liver cirrhosis ( 13 ). However, the associations between arginine pathway metabolites and fundal FVP in patients with PDR have not been established.…”

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“…Research has shown that arginine metabolism promotes skeletal muscle and cardiac fibrosis in patients with muscular dystrophy (11).Additionally, arginine methylation plays a role in regulating epithelial-mesenchymal transition (12). Protein arginine methyltransferase has been shown to promote the progression of fibrosis in conditions such as diabetic nephropathy, idiopathic pulmonary fibrosis, and liver cirrhosis (13). However, the associations between arginine pathway metabolites and fundal FVP in patients with PDR have not been established.…”