2014
DOI: 10.1002/ar.22969
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Protein Arginylation, a Global Biological Regulator that Targets Actin Cytoskeleton and the Muscle

Abstract: Posttranslational addition of Arg to proteins, mediated by arginyltransferase ATE1 has been first observed in 1963 and remained poorly understood for decades since its original discovery. Recent work demonstrated the global nature of arginylation and its essential role in multiple physiological pathways during embryogenesis and adulthood and identified over a hundred of proteins arginylated in vivo. Among these proteins, the prominent role belongs to the actin cytoskeleton and the muscle, and follow up studies… Show more

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Cited by 30 publications
(21 citation statements)
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“…Our newly gained ability to control for actin Nt‐acetylation in cellular and in vitro studies opens the way to addressing these and many related questions. The importance of post‐translational modifications of cytoskeletal components is an emerging topic, with recent studies highlighting the importance of microtubule and actin post‐translational modifications for cellular function (Janke & Bulinski, ; Kashina, ; Kerr et al, ; Robison et al, ). Actin Nt‐acetylation constitutes the latest addition to this trend, and a topic that is likely to inspire numerous follow‐up studies.…”
Section: Unresolved Questions and Perspectivesmentioning
confidence: 99%
“…Our newly gained ability to control for actin Nt‐acetylation in cellular and in vitro studies opens the way to addressing these and many related questions. The importance of post‐translational modifications of cytoskeletal components is an emerging topic, with recent studies highlighting the importance of microtubule and actin post‐translational modifications for cellular function (Janke & Bulinski, ; Kashina, ; Kerr et al, ; Robison et al, ). Actin Nt‐acetylation constitutes the latest addition to this trend, and a topic that is likely to inspire numerous follow‐up studies.…”
Section: Unresolved Questions and Perspectivesmentioning
confidence: 99%
“…Multiple prior studies demonstrated the essential role of arginylation in embryogenesis (Kwon et al, 2002), cell migration (Karakozova et al, 2006), and protein homeostasis (Kashina, 2014). Arginylation targets a large number of proteins in vivo, including some of the major components of the cytoskeleton (Saha and Kashina, 2011; Wong et al, 2007).…”
Section: Introductionmentioning
confidence: 99%
“…During the last years the function of ATE and other NERD pathway components in plant development and physiology received more and more attention (Graciet & Wellmer, ; Mendiondo et al ., ; Riber et al ., ), whereas its understanding is merely in its infancy, compared with the state of knowledge in mammals (Kashina, ).…”
Section: Introductionmentioning
confidence: 99%