Protein-based ferrogels

Mody, Puja J.; Hart, Cassidy; Romano, Siena; El-Magbri, Mariam; Esson, Moira M.; Ibeh, Trisha; Knowlton, Elizabeth D.; Zhang, Ming; Wagner, Michael J.; Hartings, Matthew R.

doi:10.1016/j.jinorgbio.2016.02.015

Cited by 5 publications

(4 citation statements)

References 40 publications

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“…In addition, it is possible to tailor the nonlinear stressstrain behavior during operation by external magnetic fields. Combined with the typically higher degree of biocompatibility of soft polymeric materials, [44][45][46][47][48] medical applications [49][50][51][52] might become possible.…”

Section: Introductionmentioning

confidence: 99%

Superelastic stress–strain behavior in ferrogels with different types of magneto-elastic coupling

Cremer

Löwen

Menzel

2016

Phys. Chem. Chem. Phys.

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Colloidal magnetic particles embedded in an elastic polymer matrix constitute a smart material called a ferrogel. It responds to an applied external magnetic field by changes in elastic properties, which can be exploited for various applications such as dampers, vibration absorbers, or actuators. Under appropriate conditions, the stress-strain behavior of a ferrogel can display a fascinating feature: superelasticity, the capability to reversibly deform by a huge amount while barely altering the applied load. In previous work, using numerical simulations, we investigated this behavior assuming that the magnetic moments carried by the embedded particles can freely reorient to minimize their magnetic interaction energy. Here, we extend the analysis to ferrogels where restoring torques by the surrounding matrix hinder rotations towards a magnetically favored configuration. For example, the particles can be chemically cross-linked into the polymer matrix and the magnetic moments can be fixed to the particle axes. We demonstrate that these systems still feature a superelastic regime. As before, the nonlinear stress-strain behavior can be reversibly tailored during operation by external magnetic fields. Yet, the different coupling of the magnetic moments causes different types of response to external stimuli. For instance, an external magnetic field applied parallel to the stretching axis hardly affects the superelastic regime but stiffens the system beyond it. Other smart materials featuring superelasticity, e.g. metallic shape-memory alloys, have already found widespread applications. Our soft polymer systems offer many additional advantages such as a typically higher deformability and enhanced biocompatibility combined with high tunability.

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Section: Introductionmentioning

confidence: 99%

Superelastic stress–strain behavior in ferrogels with different types of magneto-elastic coupling

Cremer

Löwen

Menzel

2016

Phys. Chem. Chem. Phys.

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“…These studies focused on synthesis, structure characterization, and stimuli-controlled responsivity with or without the consideration of model drug release effectiveness. 113,114 The studies include investigations of temperature-responsive volume phase transition 84,88 and subsequent magnetic heating, 91 pH-sensitivity with or without temperature-induced transition 89 and with static-field guidance, 90,92,115 and magnetization response to an applied static field. 93,95 For example, it has been reported that magnetite ( 85,125 In particular, Sunderland et al 126 130 or by employing other magnetic materials and polymers.…”

Section: Part Ii: Biomedical Applications and Translational Technologiesmentioning

confidence: 99%

Magnetic microgels and nanogels: Physical mechanisms and biomedical applications

Sung

Kim

Abelmann

2020

Bioengineering & Transla Med

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Soft micro-and nanostructures have been extensively developed for biomedical applications. The main focus has been on multifunctional composite materials that combine the advantages of hydrogels and colloidal particles. Magnetic microgels and nanogels can be realized by hybridizing stimuli-sensitive gels and magnetic nanoparticles. They are of particular interest since they can be controlled in a wide range of biological environments by using magnetic fields. In this review, we elucidate physical principles underlying the design of magnetic microgels and nanogels for biomedical applications. Particularly, this article provides a comprehensive and conceptual overview on the correlative structural design and physical functionality of the magnetic gel systems under the concept of colloidal biodevices. To this end, we begin with an overview of physicochemical mechanisms related to stimuli-responsive hydrogels and transport phenomena and summarize the magnetic properties of inorganic nanoparticles. On the basis of the engineering principles, we categorize and summarize recent advances in magnetic hybrid microgels and nanogels, with emphasis on the biomedical applications of these materials. Potential applications of these hybrid microgels and nanogels in anticancer treatment, protein therapeutics, gene therapy, bioseparation, biocatalysis, and regenerative medicine are highlighted. Finally, current challenges and future opportunities in the design of smart colloidal biodevices are discussed.

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“…These features make cobalt ferrites remarkable and outstanding candidates for many biomedical applications; however, release of higher amount of iron and cobalt ions, reduced surface functionality due to coating material (macro-biomolecules), high toxicity and greater tendency toward aggregation are the problems needed to be addressed appropriately (Marmorato et al 2011). Cobalt ferrites induce toxic effects (genotoxicity and cytotoxicity) in different organisms: mice (Abudayyak et al 2017), humans (Colognato et al 2007), guinea pig (Kapilevich et al 2010) and algae (L Ding et al 2014;Mody et al 2016). Cobalt ferrite NPs increase microbinucleated lymphocytes and decrease cytokinesis-blocked proliferation (Colognato et al 2007).…”

Section: Introductionmentioning

confidence: 99%

Functionalized cobalt ferrite cubes: toxicity, interactions and mineralization into ferritin proteins

et al. 2020

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In the biological environment, the fate of nanomaterials characterizes as critical matter, which regulates environmental effects and associated hazards for humans. Understanding of the nanoparticle's degradation, transformations and persistence may predict these risks. Safely designed inorganic nanomaterials are being focused for therapy; yet, fundamental processing in the biological environment and physical properties have not been assessed thoroughly. In this research work, bare, polyethylene glycol and citrate-coated cobalt ferrite nanoparticles (NPs) are prepared through modified chemical coprecipitation method. Structural, elemental, magnetic and morphological analysis of synthesized samples are performed through XRD, EDX, FTIR, VSM, SEM and TEM. XRD confirms the cubic structure of CoFe 2 O 4 with crystallite size 25.75 nm. SEM and TEM confirm the formation of faceted cube-like morphology. For in vivo toxicity studies, a single dose of bare and coated cobalt ferrite NPs are intraperitoneally administrated in healthy albino rats. The degradation effects are studied through optical followup, by introducing bare and coated NPs in lysosomal-like media where changes in behavior are linked with transformations in vivo. Transfer of degraded ions of cobalt ferrite NPs into apoferritin are also evaluated. Apoferritin studies reveal partial filling of protein with cobalt ions from cobalt ferrite NPs.

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Protein-based ferrogels

Cited by 5 publications

References 40 publications

Superelastic stress–strain behavior in ferrogels with different types of magneto-elastic coupling

Superelastic stress–strain behavior in ferrogels with different types of magneto-elastic coupling

Magnetic microgels and nanogels: Physical mechanisms and biomedical applications

Functionalized cobalt ferrite cubes: toxicity, interactions and mineralization into ferritin proteins

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