Protein-based nanoparticles for therapeutic nucleic acid delivery

Eweje, Feyisayo; Walsh, Michelle L.; Ahmad, Kiran; Ibrahim, Vanessa; Alrefai, Assma; Chen, Jiaxuan; Chaikof, Elliot L.

doi:10.1016/j.biomaterials.2023.122464

Cited by 3 publications

(1 citation statement)

References 284 publications

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“…Thus, the safety of PBNs and their biocompatibility as well as needed regulations were discussed in many studies focused on the rules of the US Food and Drug Administration (FDA) for approved nano-formulations. These studies addressed topics such as designing biocompatible protein NPs [116], functional protein nanoparticles [117], application of protein NPs to encapsulate functional food [118], and protein-based NPs for therapeutic nucleic acid delivery [119]. More studies are needed on foods, focusing on alternative proteins, sustainable packaging, food architecture, and precision nutrition [120].…”

Section: Protein-based Nitrogen Nanoparticlesmentioning

confidence: 99%

Nano-Food Farming: Toward Sustainable Applications of Proteins, Mushrooms, Nano-Nutrients, and Nanofibers

Prokisch,

Törős,

Nguyen

et al. 2024

Agronomy

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The relationship between agriculture and food is very close. It is impossible to produce adequate crops for global food security without proper farm management. Farming practices represent direct and indirect controlling factors in terms of global food security. Farming management practices influence agro-food production from seed germination through to the post-harvest treatments. Nano-farming utilizes nanotechnologies for agricultural food production. This review covers four key components of nano-farming: nano-mushroom production, protein-based nanoparticles, nano-nutrients, and nanofibers. This provides a comprehensive overview of the potential applications of nanotechnology in agriculture. The role of these components will be discussed in relation to the challenges faced and solutions required to achieve sustainable agricultural production. Edible mushrooms are important to food security because they are a nutritious food source and can produce nanoparticles that can be used in the production of other food sources. Protein-based nanoparticles have considerable potential in the delivery of bioactives as carriers and other applications. Nano-nutrients (mainly nano-selenium, nano-tellurium and carbon nanodots) have crucial impacts on the nutrient status of plant-based foods. Carbon nanodots and other carbon-based nanomaterials have the potential to influence agricultural crops positively. There are promising applications of nanofibers in food packaging, safety and processing. However, further research is needed to understand the impacts and potential risks of nanomaterials in the food production system.

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Section: Protein-based Nitrogen Nanoparticlesmentioning

confidence: 99%

Nano-Food Farming: Toward Sustainable Applications of Proteins, Mushrooms, Nano-Nutrients, and Nanofibers

Prokisch,

Törős,

Nguyen

et al. 2024

Agronomy

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Unleashing the potential of natural protein based nanoparticles for the delivery of therapeutic nucleic Acid: A comprehensive review

Yadav,

Ebenezer Gnanakani,

Kumar Sahu

et al. 2025

International Journal of Pharmaceutics

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Biomimetic Nucleic Acid Drug Delivery Systems for Relieving Tumor Immunosuppressive Microenvironment

Yan,

Cao,

Yin

et al. 2024

Pharmaceutics

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Immunotherapy combats tumors by enhancing the body’s immune surveillance and clearance of tumor cells. Various nucleic acid drugs can be used in immunotherapy, such as DNA expressing cytokines, mRNA tumor vaccines, small interfering RNAs (siRNA) knocking down immunosuppressive molecules, and oligonucleotides that can be used as immune adjuvants. Nucleic acid drugs, which are prone to nuclease degradation in the circulation and find it difficult to enter the target cells, typically necessitate developing appropriate vectors for effective in vivo delivery. Biomimetic drug delivery systems, derived from viruses, bacteria, and cells, can protect the cargos from degradation and clearance, and deliver them to the target cells to ensure safety. Moreover, they can activate the immune system through their endogenous activities and active components, thereby improving the efficacy of antitumor immunotherapeutic nucleic acid drugs. In this review, biomimetic nucleic acid delivery systems for relieving a tumor immunosuppressive microenvironment are introduced. Their immune activation mechanisms, including upregulating the proinflammatory cytokines, serving as tumor vaccines, inhibiting immune checkpoints, and modulating intratumoral immune cells, are elaborated. The advantages and disadvantages, as well as possible directions for their clinical translation, are summarized at last.

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Protein-based nanoparticles for therapeutic nucleic acid delivery

Cited by 3 publications

References 284 publications

Nano-Food Farming: Toward Sustainable Applications of Proteins, Mushrooms, Nano-Nutrients, and Nanofibers

Nano-Food Farming: Toward Sustainable Applications of Proteins, Mushrooms, Nano-Nutrients, and Nanofibers

Unleashing the potential of natural protein based nanoparticles for the delivery of therapeutic nucleic Acid: A comprehensive review

Biomimetic Nucleic Acid Drug Delivery Systems for Relieving Tumor Immunosuppressive Microenvironment

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