Protein biomarkers and microbial profiles in peri‐implantitis

Wang, Hom Lay; Garaicoa-Pazmiño, Carlos; Collins, Amy E; Ong, Hwen Sei; Chudri, Rini; Giannobile, William V.

doi:10.1111/clr.12708

Cited by 98 publications

(135 citation statements)

References 50 publications

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“…Smokers were excluded from the majority of the studies. Two studies included smokers and match the number of smokers in healthy and peri-implantitis groups [20,21]. …”

Section: Resultsmentioning

confidence: 99%

“…Peri-implantitis has been shown to demonstrate a similar pattern of destruction as periodontitis, and MMP upregulation has been associated with irreversible peri-implant connective tissue destruction [28]. Six studies assessed collagenases in PICF in different peri-implantitis lesions which are important around peri-implant tissues, are MMP-1, MMP-3, MMP-8, and MMP-13 and tissue inhibitors [21,29-33]. And according to all included studies, MMPs were reported to be positively correlated with clinical inflammatory conditions around implants [21,29-33].…”

Section: Discussionmentioning

confidence: 99%

“…Six studies assessed collagenases in PICF in different peri-implantitis lesions which are important around peri-implant tissues, are MMP-1, MMP-3, MMP-8, and MMP-13 and tissue inhibitors [21,29-33]. And according to all included studies, MMPs were reported to be positively correlated with clinical inflammatory conditions around implants [21,29-33]. …”

Section: Discussionmentioning

confidence: 99%

“…One of them reported no significant change after de novo plaque accumulation [25]. Thirteen studies showed higher levels of IL-1β in PICF than healthy implant sites [7,21,22,30,35,36,41-47]. Of the 10 studies assessed TNF-α, 3 of them showed no relationship with this cytokine with peri-implant inflammation [7,25,43], while other 7 studies showed significant relationship with this cytokine [23,24,36,41,46-48].…”

Section: Discussionmentioning

confidence: 99%

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Peri-Implant Crevicular Fluid Analysis, Enzymes and Biomarkers: a Systemetic Review

Dursun

Tözüm

2016

JOMR

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ObjectivesTo review the current understanding of the biomarkers and enzymes associated with different forms peri-implant diseases and how their level changes influence the pathogenesis of the inflammatory diseases around dental implants.Material and MethodsAn electronic search in two different databases was performed including MEDLINE (PubMed) and EMBASE between 1996 to 2016. Human studies analyse peri-implant crevicular fluid (PICF) biomarker and enzyme levels of implants having peri-implant mucositis and peri-implantitis published in English language, were evaluated. A systematic review was performed to assess which biomarkers and enzymes in PICF were used to identify the inflammatory conditions around dental implants.ResultsFifty-one articles were identified of which 41 were further evaluated and included in the analysis. Due to significant heterogeneity between included studies, a meta-analysis could not be performed. Instead, a systematic descriptive review was performed.ConclusionsBiomarkers and enzymes in peri-implant crevicular fluid have shown promising results in differentiating from peri-implant disease condition to health. However, due to inconsistent results and acquiring much evidence from cross-sectional studies, additional evidence supported by randomized-controlled trials is needed to validate the links reported.

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“…Smokers were excluded from the majority of the studies. Two studies included smokers and match the number of smokers in healthy and peri-implantitis groups [20,21]. …”

Section: Resultsmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

See 2 more Smart Citations

Peri-Implant Crevicular Fluid Analysis, Enzymes and Biomarkers: a Systemetic Review

Dursun

Tözüm

2016

JOMR

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“…In a recent cross-sectional study [34] where several biomarkers (IL-1β, VEGF, MMP-8, TIMP-2, and OPG) together with periodontopathogenic bacteria (A. actinomycetemcomitans, P. intermedia, P. gingivalis, T. forsythia, and T. denticola) were analysed, MMP-8 did not reveal meaningful difference among groups. Healthy and PI-affected implants were not compared based on the status of natural teeth and no treatment was given, which makes it difficult to compare the result with ours.…”

Section: (A) 3(b)mentioning

confidence: 89%

Peri-Implant Sulcus Fluid (PISF) Matrix Metalloproteinase (MMP) -8 Levels in Peri-Implantitis

Thierbach¹,

Maier²,

Sorsa

et al. 2016

JCDR

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Active MMP‐8 point‐of‐care (PoC)/chairside enzyme‐test as an adjunctive tool for early and real‐time diagnosis of peri‐implantitis

Lähteenmäki

Tervahartiala

Räisänen

et al. 2022

Clinical & Exp Dental Res

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Objective The aim of this study was to investigate the utility of the active matrix metalloproteinase (aMMP‐8)‐point‐of‐care (PoC) test as a quantitative real‐time chair‐side diagnostic tool for peri‐implant diagnosis, as well as assess the potentially developing and ongoing risk relative to the traditional clinical methods. Background Current peri‐implant and periodontal disease diagnoses rely on clinical and radiological examinations. This case‐control study investigated the applicability of aMMP‐8‐PoC immunotest for quantitative real‐time diagnosis and monitoring of dental implants in health and disease. Methods Sixty‐eight patients visiting a specialist clinic for maintenance following dental implant placement underwent assessment of their peri‐implant health. aMMP‐8‐PoC peri‐implant sulcular fluid (PISF) lateral‐flow immunotests were performed using ImplantSafe® technology quantitated by ORALyzer®. In addition, the PISF samples were analyzed for total MMP‐8, calprotectin, and interleukin (IL)‐6 by enzyme‐linked immunosorbent assays (ELISA), aMMP‐8 by western immunoblot, and MMP‐2 and MMP‐9 by gelatin zymography. Results The aMMP‐8‐PoC test promptly recorded and reflected peri‐implant disease, differentiating it clearly from health. X‐ray findings (bone loss > 2 mm), peri‐implant pocket depth ≥ 3 mm, and bleeding on probing were significantly more prevalent among implants positive for the aMMP‐8‐PoC test. aMMP‐8/ORALyzer analysis was more precise in recording disease than total MMP‐8, calprotectin, IL‐6, MMP‐2, and MMP‐9. Conclusions The aMMP‐8‐PoC test can be conveniently implemented to alert for and detect active collagenolysis affecting peri‐implant tissues, both in the early and advanced stages of the disease. Active and fragmented MMP‐8 exhibits a strong and significant association with peri‐implantitis as compared to total MMP‐8 and other biomarkers and can be utilized as the POC/chairside biomarker of choice in the new classification of peri‐implantitis.

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Protein biomarkers and microbial profiles in peri‐implantitis

Cited by 98 publications

References 50 publications

Peri-Implant Crevicular Fluid Analysis, Enzymes and Biomarkers: a Systemetic Review

Peri-Implant Crevicular Fluid Analysis, Enzymes and Biomarkers: a Systemetic Review

Peri-Implant Sulcus Fluid (PISF) Matrix Metalloproteinase (MMP) -8 Levels in Peri-Implantitis

Active MMP‐8 point‐of‐care (PoC)/chairside enzyme‐test as an adjunctive tool for early and real‐time diagnosis of peri‐implantitis

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