Protein Biomarkers in Chronic Kidney Disease in Children—What Do We Know So Far?

Szumińska, Agnieszka Rybi; Wasilewska, Anna; Kamianowska, Monika

doi:10.3390/jcm12123934

Cited by 5 publications

(3 citation statements)

References 115 publications

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“…Neutrophil-gelatinase-associated lipocalin (NGAL), interleukin 18 (IL-18), and liver-type fatty-acid-binding protein (L-FABP) are identified as potential biomarkers of tubular injury, with NGAL particularly promising due to its established diagnostic and prognostic roles in obstructive hydronephrosis and other CAKUT [33,35,36]. NGAL, a protein produced by activated neutrophils, exhibits complex activities beyond its antibacterial function and is implicated in the early detection of acute kidney injury [42][43][44]. Beta trace protein (BTP), β2-microglobulin (B2M), and Klotho are also explored as biomarkers for assessing renal function, with BTP and B2M showing correlations with traditional markers of CKD and Klotho exhibiting inconsistent results [41,45,46].…”

Section: Discussionmentioning

confidence: 99%

A Pilot Comparative Study between Creatinine- and Cystatin-C-Based Equations to Estimate GFR and Kidney Ultrasound Percentiles in Children with Congenital Anomalies of the Kidney and Urinary Tract

Steflea,

Stroescu,

Gafencu

et al. 2024

Diagnostics

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Congenital anomalies affecting the kidneys present significant challenges in pediatric nephrology, needing precise methods for assessing renal function and guiding therapeutic intervention. Bedside Schwartz formula with the cystatin-C-based Full Age Spectrum formula and Chronic Kidney Disease in Children (CKiD) U 25 formula used in estimating glomerular filtration rate (eGFR) and also to assess if the eGFR in association with kidney length percentiles can be a monitoring parameter for the progression of chronic kidney disease in children with congenital anomalies of the kidney and urinary tract (CAKUT). A total of 64 pediatric patients (median age at diagnostic was 12 months with an interquartile range of 2 to 60) were diagnosed with congenital anomalies in the kidney and urinary tract between June 2018 and May 2023 at “Louis Turcanu” Emergency Hospital for Children in Timisoara, Romania. Baseline characteristics, CAKUT types, associated pathologies, CKD staging, and eGFR using creatinine and cystatin C were analyzed. The mean age at the moment of examination was 116.50 months; (65, 180). Chronic kidney disease staging revealed a predominance of patients in CKD stages G1 and A1. Analysis of eGFR methods revealed a small mean difference between eGFR estimated by creatinine and cystatin C, with a moderate-strong positive correlation observed between the eGFR and ultrasound parameters. Using cystatin-C-based formulas for eGFR, in conjunction with ultrasound measurements, may offer reliable insights into renal function in pediatric patients with congenital anomalies affecting the kidney and urinary tract. However, the economic aspect must be taken into consideration because cystatin C determination is approximately eight times more expensive than that of creatinine. An interdisciplinary approach is crucial for managing patients with CAKUT.

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Section: Discussionmentioning

confidence: 99%

A Pilot Comparative Study between Creatinine- and Cystatin-C-Based Equations to Estimate GFR and Kidney Ultrasound Percentiles in Children with Congenital Anomalies of the Kidney and Urinary Tract

Steflea,

Stroescu,

Gafencu

et al. 2024

Diagnostics

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“…Lupus nephritis severity correlated with urinary MCP-1 (uMCP-1) levels in pediatric patients. Similarly, MCP-1 was higher in patients with chronic kidney disease (CKD) or autosomal recessive polycystic kidney disease (ARPKD) when compared to healthy controls [74]. In urolithiasis, MCP-1 may find its place as well.…”

Section: Monocyte Chemoattractant Proteinmentioning

confidence: 99%

Current Status of Protein Biomarkers in Urolithiasis—A Review of the Recent Literature

Lasota,

Wasilewska,

Rybi-Szumińska

2023

JCM

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Urolithiasis is an increasingly common clinical problem worldwide. The formation of stones is a combination of metabolic status, environmental factors, family history and many other aspects. It is important to find new ways to quickly detect and assess urolithiasis because it causes sudden, severe pain and often comes back. One way to do this is by exploring new biomarkers. Current advances in proteomic studies provide a great opportunity for breakthroughs in this field. This study focuses on protein biomarkers and their connection to kidney damage and inflammation during urolithiasis.

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“…Activated uPAR can be degraded and detected in systemic circulation in its soluble form, suPAR (glycosyl-phosphatidyl inositol anchored 3-domain membrane protein). uPAR/suPAR can cause glomerular damage in podocytes via the αvβ3 integrin pathway [60]. Concentrations of suPAR in serum and urine are considered to reflect endothelial dysfunction and immune and inflammatory activation.…”

Section: Our Findings About Abpmmentioning

confidence: 99%

Time to Change Our Viewpoints to Assess Renal Risks in Patients with Solitary Kidneys beyond Traditional Approaches?

Alp,

Saruhan,

Doğan

et al. 2023

JCM

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Solitary functioning kidney (SFK) can be defined as the absence or hypofunction of a kidney due to acquired or congenital reasons. A congenital solitary functioning kidney (cSFK) is more common than is an acquired one (aSFK) and is characterized by the anatomical absence (agenesis) or hypofunction (hypoplasia; hypodysplasia) of one kidney from birth. Among the acquired causes, the most important is nephrectomy (Nx) (due to the donor, trauma or mass resection). Patients with SFK are at risk for the development of chronic kidney disease (CKD) in the long term. This risk potential is also significantly affected by hypertension. The relationship between hypertension and subclinical chronic inflammation is a connection that has not yet been fully clarified pathogenetically, but there are many studies highlighting this association. In recent years, studies examining different fibrosis and inflammation biomarkers in terms of the evaluation and prediction of renal risks have become increasingly popular in the literature. Oxidative stress is known to play an important role in homocysteine-induced endothelial dysfunction and has been associated with hypertension. In our study, we aimed to investigate the relationship between ambulatory blood pressure monitoring (ABPM) and urinary/serum fibrosis and inflammatory markers in patients with SFK. We prospectively investigated the relationship between ABPM results and soluble urokinase plasminogen activator receptor (suPAR), procollagen type III N-terminal peptide (PIIINP), homocysteine and other variables in 85 patients with SFK and compared them between cSFK and aSFK groups. In the etiology of SFK, a congenital or acquired origin may differ in terms of the significance of biomarkers. In particular, the serum homocysteine level may be associated with different clinical outcomes in patients with cSFK and aSFK.

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Protein Biomarkers in Chronic Kidney Disease in Children—What Do We Know So Far?

Cited by 5 publications

References 115 publications

A Pilot Comparative Study between Creatinine- and Cystatin-C-Based Equations to Estimate GFR and Kidney Ultrasound Percentiles in Children with Congenital Anomalies of the Kidney and Urinary Tract

A Pilot Comparative Study between Creatinine- and Cystatin-C-Based Equations to Estimate GFR and Kidney Ultrasound Percentiles in Children with Congenital Anomalies of the Kidney and Urinary Tract

Current Status of Protein Biomarkers in Urolithiasis—A Review of the Recent Literature

Time to Change Our Viewpoints to Assess Renal Risks in Patients with Solitary Kidneys beyond Traditional Approaches?

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