Protein-Bound Iodine Levels in Normal and in Diabetic Children

THYROID FUNCTION STUDIES IN CHILDREN: NORMAL VALUES FOR THYROIDAL I131UPTAKE AND PBI131LEVELS UP TO THE AGE OF 18*

“…Serum butanol-extractable iodine (thyroxine) values have been found to be within the normal adult range in children as a group, but up to 7 years of age they appeared to be higher than in adults (20). PBI levels studied up to the age of 18 have been reported to be within the normal adult range, but to be decreased with increase in age; the lowest values were noted during early adolescence (21).…”

The interpretation of the serum protein-bound iodine: A review

“…Danowski, Huff, Erhard, Price, Brown, Wirth, and Stevenson (1952) reported a steady decrease with age up to 12-14 years followed by an increase up to adult levels. The changes were more marked in girls than in boys.…”

Variation in the morphometry of the normal human thyroid in growth and ageing

“…3) occupied by the acinar space rises significantly from 36.9 during 0-5 yr to 55.8 during the period 15-20 yr (P<O.OOl). During this period of growth, biochemical studies have shown that the level of serum protein bound iodine remains constant (Oddie et al, 1966), although Danowski et al (1952) found low concentrations in children aged 12-14 yr. Functional studies on euthyroid infants and young adults are scanty due to the dangers of exposure to radio-isotopes. However, several investigations (Quimby et al, 1947, Oliner et al, 1957, Oliner et al, 1958, and Croughs et al, 1965 have shown that although the mean uptake of radio-iodine by the thyroid gland at 24 hr is the same as in adults, the subsequent levels of labelled protein bound iodine were raised at 24 and 48 hr.…”