Protein C prevents the coagulopathic and lethal effects of Escherichia coli infusion in the baboon.

The cytokine‐mediated imbalance between coagulant and anticoagulant mechanisms in sepsis and endotoxaemia

“…Antithrombin III, the main inhibitor of thrombin and factor Xa, is rapidly consumed by the ongoing thrombin formation, resulting in (very) low levels of this protease inhibitor [4]. The importance of sufficient plasma levels of antithrombin III has been shown in experimental and clinical studies [21,22]. In addition, a significant down-regulation of the protein C-protein S system may occur.…”

The Characterization of Mice with a Targeted Combined Deficiency of Protein C and Factor XI

“…6,7 aPC has also been implicated in host-defense reactions that occur during intravascular inflammation. 8 Although a targeted deficiency of PC in mice led to early neonatal death, 9 a similar total deficiency of FXI did not result in severe consequences in the unchallenged animal. 10 Because of the nature of these phenotypes, an opportunity was present to examine the effect of an additional FXI deficiency on the phenotypes of PC-deficient animals.…”

Proteína C ativada no tratamento de recém-nascido com sepse, choque e disfunção de múltiplos órgãos e sistemas: relato de caso e revisão de literatura

“…Na década de 1980, Taylor e col. obtiveram informações preliminares para a compreensão do papel da PCA na sepse. Demonstraram que a infusão de PCA exógena preveniu a diminuição dos níveis de fibrinogênio quando doses letais de E. coli eram administradas a babuí-nos 26 . Na década de 1990, Leclere e col. demonstraram que a deficiência de PC em crianças com púrpura infecciosa grave estavam associada à CIVD, choque e óbito 27 .…”