Protein-coated nanoparticles embedded in films as delivery platforms

Morales, Javier; Ross, Alistair C.; McConville, Jason T.

doi:10.1111/jphp.12046

Cited by 30 publications

(10 citation statements)

References 41 publications

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“…The adhesive strength increased with increasing irradiation dose up to 50 kGy and decreased at 70 kGy. Modest gamma-ray irradiation is needed to improve the bioadhesion of a hydrogel [5]. This indicates that the appropriate crosslinking structure induces an effective chain entanglement between the glycoproteins of the mucus and the mucoadhesive polymer; however, higher crosslinking prevents such as a chain entanglement.…”

Section: Mucoadhesive Propertiesmentioning

confidence: 98%

“…Typical polymers used as mucoadhesive drug carriers include poly(acrylic acid) (PAA), poly(methacrylic acid) (PMA), carboxymethyl cellulose (CMC), modified chitosan, and hydroxypropyl methylcelluose [5][6][7][8][9]. Of these polymers, PAA and its crosslinked commercial powder forms, Carbopol and Polycarbophil, usually show strong mucoadhesive properties.…”

Section: Introductionmentioning

confidence: 99%

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Poly(acrylic acid)/polyethylene glycol hygrogel prepared by using gamma-ray irradiation for mucosa adhesion

Nho

Park

Shin

et al. 2015

Journal of the Korean Physical Society

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A buccal delivery system provides a much milder environment for drug delivery compared to an oral delivery which presents a hostile environment for drugs, especially proteins and polypeptides, owing to acid hydrolysis. Local delivery in an oral cavity has particular applications in the treatment of toothaches, periodontal disease, and bacterial infections. Poly(acrylic acid) (PAA)-based hydrogels prepared using a chemical initiator have been attempted for a mucoadhesive system owing to their flexibility and excellent bioadhesion. In this experiment, PAA and polyethylene glycol (PEG) were selected to prepare using a radiation process a bioadhesive hydrogel for adhesion to mucosal surfaces. PAA and PEG were dissolved in purified water to prepare a homogeneous PAA/PEG solution, and the solution was then irradiated using an electron beam at dose up to 70 kGy to make the hydrogels. Their physical properties, such as gel percent, swelling percent, and adhesive strength to mucosal surfaces, were investigated. In this experiment, various amounts of PEG were incorporated into the PAA to enhance the mucoadhesive property of the hydrogels. The effect of the molecular weight of PEG on the mucoadhesion was also examined.

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Section: Mucoadhesive Propertiesmentioning

confidence: 98%

Section: Introductionmentioning

confidence: 99%

Poly(acrylic acid)/polyethylene glycol hygrogel prepared by using gamma-ray irradiation for mucosa adhesion

Nho

Park

Shin

et al. 2015

Journal of the Korean Physical Society

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show abstract

“…Indeed PEG-b-PLA nanoparticles erosion was shown to first depend on the swelling of polymeric matrix and then from the nanoparticles. Similarly, another oral film formulation was impregnated with nanoparticles coated with lysozyme attaining sustained release (4 h) observable when using a Franz diffusion cell to mimic buccal cavity [79].…”

Section: Accepted Manuscriptmentioning

confidence: 99%

Oral films as breakthrough tools for oral delivery of proteins/peptides

Castro

Fonte

Sousa

et al. 2015

Journal of Controlled Release

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“…[44] Four strips from each formulation were selected and weighed accurately on a digital electronic weighing balance in triplicate manner. [44] Four strips from each formulation were selected and weighed accurately on a digital electronic weighing balance in triplicate manner.…”

Section: Weight Uniformitymentioning

confidence: 99%

In vitro and ex vivo assessment of hydrophilic polymer‐ and plasticizer‐based thin buccal films designed by using central composite rotatable design for the delivery of meloxicam

Zaman

Hanif

2017

Adv Polym Technol

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The purpose of the study was to design a dosage form with ability to deliver drug immediately, hence providing rapid relief in certain pain ailments. Meloxicam (MLX) was selected as a model drug and buccal films were designed by using the solvent casting technique. A central composite rotatable design (CCRD) was used as a statistical tool to design and optimize the film formulations. No noticeable interaction was found between the drug and polymer when they were subjected to Fourier transform infrared spectroscopy (FTIR). Scanning electron microscopy (SEM) revealed the smooth surface of the film and uniform mixing of drug and polymer.X-ray diffractometry (XRD) was carried out to observe crystalline and amorphous nature of meloxicam. Differential scanning calorimetric (DSC) analysis was used to investigate the thermal behavior of free drug and drug-loaded formulation. The prepared film showed good mechanical property as folding endurance was found to be greater than 100 in all formulations. The cumulative drug release was found to be more than 80% in initial at dissolution time of 5 min, when the prepared films were subjected to dissolution studies in phosphate buffer at pH 6.8. Thus, it can be concluded that the hydrophilic polymer and plasticizer have definite impact on formulation and characteristics of rapidly dissolving buccal films and have the ability to prepare a suitable immediate release buccal film of meloxicam. K E Y W O R D Sbuccal films, drug delivery system, ex-vivo permeation, hydrophilic polymer, meloxicam, plasticizer, solvent casting method

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Protein-coated nanoparticles embedded in films as delivery platforms

Abstract: Mucoadhesive films containing protein-coated nanoparticles are promising carriers for the buccal delivery of proteins and peptides in a stable form.

Cited by 30 publications

References 41 publications

Poly(acrylic acid)/polyethylene glycol hygrogel prepared by using gamma-ray irradiation for mucosa adhesion

Poly(acrylic acid)/polyethylene glycol hygrogel prepared by using gamma-ray irradiation for mucosa adhesion

Oral films as breakthrough tools for oral delivery of proteins/peptides

In vitro and ex vivo assessment of hydrophilic polymer‐ and plasticizer‐based thin buccal films designed by using central composite rotatable design for the delivery of meloxicam

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