Protein contact dermatitis: myth or reality?

Janssens, Veronique; Morren, Marie‐Anne; Dooms‐Goossens, A.; Degreef, Hugo

doi:10.1111/j.1365-2133.1995.tb08616.x

Cited by 140 publications

(100 citation statements)

References 40 publications

(13 reference statements)

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“…The substance can penetrate via the SC, including the corneocytes and the lipid layers, or via the follicles. Skin reactions were observed after contact with substances containing proteins up to a molecular weight of 75 kDa [16,51,52] . Bos and Meinardi [53] argue that the molecular weight of a compound must be below 0.5 kDa to allow skin absorption in healthy skin, whereas for atopic skin, also molecules of slightly over 0.8 kDa can be absorbed.…”

Section: Discussionmentioning

confidence: 99%

Penetration of Pollen Proteins into the Skin

Jacobi

Engel²,

Patzelt³

et al. 2007

Skin Pharmacol Physiol

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Atopic dermatitis is a chronic remittent skin disease. In the extrinsic form of atopic dermatitis, type IgE-mediated reactions play an important pathophysiological role. The aim of the present study was to examine whether type I allergens can penetrate into the skin. Therefore, pollen proteins were labeled with fluorescein isothiocyanate (FITC), and their penetration profile was studied qualitatively. Solutions of FITC-labeled pollen proteins were applied in vitro on porcine skin and in vivo on human skin. In vitro, the FITC-labeled proteins were observed within the complete stratum corneum (SC) and inside the hair follicles even 15 min after application. They were also distributed inside the dermis around the hair follicles. In vivo, a similar pattern of distribution within the SC and the hair follicles was observed. These results indicate penetration via the SC lipid layers and a faster penetration via the hair follicles. The FITC-labeled proteins entered the dermis via the follicular pathway. Therefore, the follicular penetration should be considered in the development of skin protection strategies. To evaluate such strategies, the developed method can be used, and further studies in atopic dermatitis patients are necessary to determine whether the penetration of type I allergens is increased.

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Section: Discussionmentioning

confidence: 99%

Penetration of Pollen Proteins into the Skin

Jacobi

Engel²,

Patzelt³

et al. 2007

Skin Pharmacol Physiol

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“…It is followed by worsening of the dermatitis within hours or days [19][20][21][22][23]. Protein contact dermatitis can be of irritant (nonspecific) or allergic (IgE-mediated) type.…”

Section: Nonimmunological Contact Urticariamentioning

confidence: 99%

Plants and Plant Products

Coz¹,

Ducombs²

2006

Contact Dermatitis

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“…Gelegentlich treten auch kurz nach dem direkten Hautkontakt mit Proteinen akute urtikarielle oder vesikulöse Hautveränderungen auf. Durch eine häufige Reexposition im Rahmen einer beruflichen Tätigkeit sind die Läsionen meist an Händen und Unterarmen lokalisiert [3,5,9].…”

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