Protein-Cross-Linked Triple-Responsive Polymer Networks Based on Molecular Recognition

Chen, Fan; Hou, Wangmeng; Wu, Danni; Wu, Yunfang; Cheng, Guochen; Zhao, Hanying

doi:10.1021/acsmacrolett.6b00750

Cited by 19 publications

(19 citation statements)

References 44 publications

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“…Cleavable disulfide bonds are employed to connect the protein molecules to the polymer scaffolds, so that the protein molecules can be released under reduced conditions. A strategy to synthesize triple-responsive polymer-protein networks based on molecular recognition was reported by Chen et al [219] βCD-modified BSA was prepared by thioldisulfide exchange reaction, and PAM with pendant Ad groups was prepared by free-radical copolymerization. The modified BSA was added into the aqueous solution of PAM, resulting in the formation of polymer-protein network structures, due to strong inclusion interaction between βCD and Ad.…”

Section: Synthesis Of Protein-polymer Nanogels/hydrogelsmentioning

confidence: 99%

Fabrication of Polymer–Protein Hybrids

Zhang

Zhao

2018

Macromol. Rapid Commun.

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Rapid developments in organic chemistry and polymer chemistry promote the synthesis of polymer-protein hybrids with different structures and biofunctionalities. In this feature article, recent progress achieved in the synthesis of polymer-protein conjugates, protein-nanoparticle core-shell structures, and polymer-protein nanogels/hydrogels is briefly reviewed. The polymer-protein conjugates can be synthesized by the "grafting-to" or the "grafting-from" approach. In this article, different coupling reactions and polymerization methods used in the synthesis of bioconjugates are reviewed. Protein molecules can be immobilized on the surfaces of nanoparticles by covalent or noncovalent linkages. The specific interactions and chemical reactions employed in the synthesis of core-shell structures are discussed. Finally, a general introduction to the synthesis of environmentally responsive polymer-protein nanogels/hydrogels by chemical cross-linking reactions or molecular recognition is provided.

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Section: Synthesis Of Protein-polymer Nanogels/hydrogelsmentioning

confidence: 99%

Fabrication of Polymer–Protein Hybrids

Zhang

Zhao

2018

Macromol. Rapid Commun.

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“…Stimuli‐responsive polymers and injectable hydrogels based on biocompatible and biodegradable precursors that disintegrate into nontoxic degradation products on exposure with available external conditions are highly desirable for biomedical applications . These stimuli‐responsive polymers and hydrogels have wide applications in drug delivery, emulsification, identification, detection, sensing, coatings, and so forth . The response of such smart polymers (block, graft, star, cyclic, and cross‐linked/hyperbranched polymers) and hydrogels to stimuli such as pH, temperature, redox, light (ultraviolet or visible), and magnetic field has been widely and extensively studied in last decades .…”

Section: Introductionmentioning

confidence: 99%

“…Stimuli‐responsive functional groups on these polymers can be introduced by modification reactions such as EDC, DCC, and other click/coupling reactions . On the other hand, aliphatic synthetic polymers with stimuli‐responsive groups and the hydrogels therefrom have been widely explored …”

Section: Introductionmentioning

confidence: 99%

“…Injectable hydrogels with single stimuli‐sensitive group such as acetal, hydrazone, oxime, disulfide, and so forth either in the hydrogel backbone or in the cross‐linker have been synthesized in past decades for targeted anticancer drug delivery and other biological applications . Hydrogel systems which respond to the combination of two or multiple stimuli would be more attractive for targeted or selective and fast/burst release of the encapsulated payloads than the single stimulus‐responsive hydrogels . Therefore, a pH and temperature dual‐responsive injectable hydrogel with a self‐healing ability was prepared by Yu et al by simply mixing the aldehyde modified F127 (PEO‐PPO‐PEO) and acylhydrazine in water to be used only under mildly acidic conditions .…”

Section: Introductionmentioning

confidence: 99%

“…[1][2][3][4] These stimuli-responsive polymers and hydrogels have wide applications in drug delivery, emulsification, identification, detection, sensing, coatings, and so forth. 3,[5][6][7][8][9][10] The response of such smart polymers (block, graft, star, cyclic, and cross-linked/hyperbranched polymers) and hydrogels to stimuli such as pH, temperature, redox, light (ultraviolet or visible), and magnetic field has been widely and extensively studied in last decades. [3][4][5][6][7][11][12][13][14][15][16][17][18][19] Stimuli-responsive amphiphilic polymers tend to self-assemble in different morphologies in the aqueous solution and can noncovalently encapsulate hydrophobic dyes and drugs in their self-assembled structures.…”

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confidence: 99%

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pH and reduction dual‐stimuli‐responsive PEGDA/PAMAM injectable network hydrogels via aza‐michael addition for anticancer drug delivery

Patil

Shinde

Misra

2018

J. Polym. Sci. Part A: Polym. Chem.

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A pH and reduction dual‐stimuli‐responsive PEGDA/PAMAM injectable network hydrogel containing “acetals” as pH‐sensitive groups and “disulfides” as reducible linkages was designed and synthesized via aza‐Michael addition reaction between PAMAM and PEGDA diacrylates. The pore size and swelling ratio of hydrogels was varied from 14 ± 3 to 19 ± 4 μm and 214 ± 13 to 300 ± 19 μm, respectively, with varying ethylene glycol repeating units in diacrylates. The swelling ratio of PEGDA/PAMAM network hydrogel increased with increase in the molecular weight of PEG and with decrease in pH. The presence of different cationizable amino‐functionalities in PEGDA/PAMAM network hydrogel helped to enhance the swelling ability of hydrogel under the acidic conditions. The continuous increase in metabolically active live HeLa cells with time in MTT assay implied biocompatibility/noncytotoxicity of the synthesized PEGDA/PAMAM injectable network hydrogel. Furthermore, the prepared PEGDA/PAMAM hydrogel showed higher degradation at lower pH and at higher concentration of DTT. The burst release of doxorubicin from PEGDA/PAMAM hydrogel under the environment of the lower pH and in presence of DTT compared to the release at normal physiological pH and in absence of DTT suggested the potential ability of this model hydrogel system for targeted and selective anticancer drug release at tumor tissues. © 2018 Wiley Periodicals, Inc. J. Polym. Sci., Part A: Polym. Chem. 2018, 56, 2080–2095

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Complementary Dynamic Chemistries for Multifunctional Polymeric Materials

Zhang

Watuthanthrige

Wanasinghe

et al. 2021

Adv Funct Materials

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Dynamic materials (DMs) or dynamers have potential applications across a broad range of material science challenges. These applications include sustainable materials as a part of the circular plastics economy, advanced materials with tailored high stress properties and biomedical agents. DMs are comprised of polymers that crosslinked through reversible covalent and noncovalent linking groups. This group provides reversible bonds, which impart properties such as (re)healing, adaptability, toughness into a material. The nature of the linker dictates the dynamer's stability and dynamic properties, although for many applications one linker alone cannot give materials with complex multiresponsive functions. The combination of multiple dynamic linkers can introduce complementary functionalities into a single material. This combination of linkers enhances the collective material properties by matching their strengths and offsetting the weaknesses, or by selecting linkers for specific functions, such as one linker for rapid exchange and the other to respond to external stimuli. This contribution highlights the possibilities and unique features of materials containing multiple dynamic linkers, reviewing both fundamental discoveries of materials possessing multiple dynamic bonds and applications facilitated by the presence of multiple linking group chemistry.

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Protein-Cross-Linked Triple-Responsive Polymer Networks Based on Molecular Recognition

Cited by 19 publications

References 44 publications

Fabrication of Polymer–Protein Hybrids

Fabrication of Polymer–Protein Hybrids

pH and reduction dual‐stimuli‐responsive PEGDA/PAMAM injectable network hydrogels via aza‐michael addition for anticancer drug delivery

Complementary Dynamic Chemistries for Multifunctional Polymeric Materials

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