Protein detection by optical shift of a resonant microcavity

Vollmer, Frank; Braun, Dieter; Libchaber, Albert; Khoshsima, M.; Teraoka, Iwao; Arnold, Stephen

doi:10.1063/1.1482797

Cited by 847 publications

(622 citation statements)

References 15 publications

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“…The low absorption loss across the visible and near-IR wavelengths, on the other hand, allows SiN x to be used with a diverse set of atomic and atomiclike ͑col-loidal quantum dots, color centers, etc.͒ species. Beyond the particular focus of this work on cavity QED experiments with cold alkali atoms, high-Q SiN x microcavities are also well suited to experiments involving moderate refractive index environments, such as sensitive detection of analytes contained in a fluid solution 18 or absorbed into a low index polymer cladding. 19 The SiN x microdisk resonators in this work were fabricated from a commercially available Si wafer with a 250 nm thick stoichiometric SiN x ͑n = 2.0͒ layer grown on the surface by low pressure chemical vapor deposition ͑LPCVD͒.…”

mentioning

confidence: 99%

Integration of fiber-coupled high-Q SiNx microdisks with atom chips

Barclay

Srinivasan

Painter

et al. 2006

Applied Physics Letters

130

100

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Micron scale silicon nitride ͑SiN x ͒ microdisk optical resonators are demonstrated with Q = 3.6 ϫ 10 6 and an effective mode volume of 15͑ / n͒ 3 at near-visible wavelengths. A hydrofluoric acid wet etch provides sensitive tuning of the microdisk resonances, and robust mounting of a fiber taper provides efficient fiber optic coupling to the microdisks while allowing unfettered optical access for laser cooling and trapping of atoms. Measurements indicate that cesium adsorption on the SiN x surfaces significantly red detunes the microdisk resonances. Parallel integration of multiple ͑10͒ microdisks with a single fiber taper is also demonstrated.

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mentioning

confidence: 99%

Integration of fiber-coupled high-Q SiNx microdisks with atom chips

Barclay

Srinivasan

Painter

et al. 2006

Applied Physics Letters

130

100

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“…5 In recent years, optical microcavities have risen to compete with SPR-based systems. Microcavities can be amazingly sensitive, with demonstrated ability to detect single viruses 6 and perhaps even single biomolecules 7 (the latter remains the subject of some debate, 8 however there is no doubt that the mass detection limits are small 9 ). In microcavities, the detection mechanism relies upon changes in the optical resonances caused by the presence of an analyte within the electric field profile of the resonance.…”

Section: Introductionmentioning

confidence: 99%

Synthesis and Operation of Fluorescent-core Microcavities for Refractometric Sensing

McFarlane

Manchee

Silverstone

et al. 2013

JoVE

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This paper discusses fluorescent core microcavity-based sensors that can operate in a microfluidic analysis setup. These structures are based on the formation of a fluorescent quantum-dot (QD) coating on the channel surface of a conventional microcapillary. Silicon QDs are especially attractive for this application, owing in part to their negligible toxicity compared to the II-VI and II-VI compound QDs, which are legislatively controlled substances in many countries. While the ensemble emission spectrum is broad and featureless, an Si-QD film on the channel wall of a capillary features a set of sharp, narrow peaks in the fluorescence spectrum, corresponding to the electromagnetic resonances for light trapped within the film. The peak wavelength of these resonances is sensitive to the external medium, thus permitting the device to function as a refractometric sensor in which the QDs never come into physical contact with the analyte. The experimental methods associated with the fabrication of the fluorescent-core microcapillaries are discussed in detail, as well as the analysis methods. Finally, a comparison is made between these structures and the more widely investigated liquid-core optical ring resonators, in terms of microfluidic sensing capabilities. Video LinkThe video component of this article can be found at

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“…Optical micro-resonators are currently attracting a lot of interest in a variety of fields ranging from telecommunication [1] to biological/chemical sensors [2]. In particular, the advancement of microdisk resonators may lead to the development of compact and integrable optical-electronic devices.…”

Section: Introductionmentioning

confidence: 99%

Simultaneous optical trapping and detection of atoms by microdisk resonators

et al. 2006

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We propose a scheme for simultaneously trapping and detecting single atoms near the surface of a substrate using whispering gallery modes of a microdisk resonator. For efficient atom-mode coupling the atom should be placed within approximately 150 nm from the disk. We show that a combination of red and blue detuned modes can form an optical trap at such distances while the back-action of the atom on the field modes can simultaneously be used for atom detection. We investigate these trapping potentials including van-der-Waals and Casimir-Polder forces and discuss corresponding atom detection efficiencies, depending on a variety of system parameters. Finally, we analyze the feasibility of non-destructive detection.

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Protein detection by optical shift of a resonant microcavity

Cited by 847 publications

References 15 publications

Integration of fiber-coupled high-Q SiNx microdisks with atom chips

Integration of fiber-coupled high-Q SiNx microdisks with atom chips

Synthesis and Operation of Fluorescent-core Microcavities for Refractometric Sensing

Simultaneous optical trapping and detection of atoms by microdisk resonators

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