Protein encapsulation of nanocatalysts: A feasible approach to facilitate catalytic theranostics

Jin, Duo; Liu, Manman; Zhang, Meng; Yu, Wenxin; Yu, Jiaji; Shen, Adong; Cheng, Junjie; Liu, Yangzhong

doi:10.1016/j.addr.2022.114648

Cited by 9 publications

(2 citation statements)

References 233 publications

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“…In order to ensure their safe clinical applications, we evaluated the safety of HAVH to cells and animal bodies. [ 50 ] We assessed the hemolytic activity of HAVH and HAVH_NIR by incubating them with red blood cells for 1 h. Even at a high concentration of 512 µg mL −1 , the hemolysis rates of HAVH and HAVH_NIR were below 5% (Figure S24, Supporting Information), indicating that neither HAVH nor HAVH_NIR caused any significant hemolysis. [ 51 ] We then evaluated the cytotoxicity of HAVH toward mouse fibroblasts L929 cells.…”

Section: Resultsmentioning

confidence: 99%

A Molecular Switch‐Integrated Nanoplatform Enables Photo‐Unlocked Antibacterial Drug Delivery for Synergistic Abscess Therapy

Yan

Liu

et al. 2023

Adv Healthcare Materials

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Drug delivery systems (DDSs) capable of sequential multistage drug release are urgently needed for antibacterial applications. Herein, a molecular switch‐integrated, photo‐responsive nanoplatform is reported based on hollow mesoporous silica nanospheres (HMSN) loaded with silver nanoparticles (Ag NPs), vancomycin (Van), and hemin (HAVH) for bacteria elimination and abscess therapy. Upon near‐infrared (NIR) light irradiation, the molecular switch, hemin, can effuse from the mesopores of HMSN, triggering the release of pre‐loaded Ag+ and Van, which enables photothermal‐modulated drug release and synergistic photothermal‐chemo therapy (PTT‐CHT). The HAVH_NIR irreversibly disrupts the bacterial cell membrane, facilitating the penetration of Ag+ and Van. It is found that these compounds restrain the transcription and translation of ribosomes and lead to rapid bacterial death. Furthermore, hemin can effectively inhibit excessive inflammatory responses associated with the treatment, promoting accelerated wound healing in a murine abscess model. This work presents a new strategy for antibacterial drug delivery with high controllability and extendibility, which may benefit the development of smart multifunctional nanomedicine for diseases not limited to bacterial infections.

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Section: Resultsmentioning

confidence: 99%

A Molecular Switch‐Integrated Nanoplatform Enables Photo‐Unlocked Antibacterial Drug Delivery for Synergistic Abscess Therapy

Yan

Liu

et al. 2023

Adv Healthcare Materials

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“…Beside cell membrane, various biomacromolecules with excellent biocompatibility, low immunogenicity and targeting nature, such as proteins, peptides, and nucleic acids are expected to integrate the functions and advantages of both biomolecules and nanozymes. [ 90 ] For example, due to the natural targeting ability of ferritin to the transferrin receptor 1 (TfR1), the nanozymes modified with ferritin showed specific and high toxicity to the cells expressing a high level of TfR1. [ 13 ] In contrast, the toxicity was significantly reduced due to the low uptake in the cells expressing low levels of TfR1, suggesting the excellent targeting and selectivity of the ferritin‐modified nanozymes.…”

Section: Surface Engineeringmentioning

confidence: 99%

Engineering Single‐Atom Nanozymes for Catalytic Biomedical Applications

Yang

Liao

Zou

et al. 2023

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Nanomaterials with enzyme‐mimicking properties, coined as nanozymes, are a promising alternative to natural enzymes owing to their remarkable advantages, such as high stability, easy preparation, and favorable catalytic performance. Recently, with the rapid development of nanotechnology and characterization techniques, single atom nanozymes (SAzymes) with atomically dispersed active sites, well‐defined electronic and geometric structures, tunable coordination environment, and maximum metal atom utilization are developed and exploited. With superior catalytic performance and selectivity, SAzymes have made impressive progress in biomedical applications and are expected to bridge the gap between artificial nanozymes and natural enzymes. Herein, the recent advances in SAzyme preparation methods, catalytic mechanisms, and biomedical applications are systematically summarized. Their biomedical applications in cancer therapy, oxidative stress cytoprotection, antibacterial therapy, and biosensing are discussed in depth. Furthermore, to appreciate these advances, the main challenges, and prospects for the future development of SAzymes are also outlined and highlighted in this review.

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Boosting Ferroptosis Therapy with Iridium Single‐Atom Nanocatalyst in Ultralow Metal Content

Cheng

Jin

et al. 2023

Advanced Materials

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Nanocatalysts are promising tumor therapeutics due to their ability to induce reactive oxygen species in the tumor microenvironment. Although increasing metal loading can improve catalytic activity, the quandary of high metal content versus potential systemic biotoxicity remains challenging. Here, a fully exposed active site strategy by site‐specific anchoring of single iridium (Ir) atoms on the outer surface of a nitrogen‐doped carbon composite (Ir single‐atom catalyst (SAC)) is reported to achieve remarkable catalytic performance at ultralow metal content (≈0.11%). The Ir SAC exhibits prominent dual enzymatic activities to mimic peroxidase and glutathione peroxidase, which catalyzes the conversion of endogenous H2O2 into •OH in the acidic TME and depletes glutathione (GSH) simultaneously. With an advanced support of GSH‐trapping platinum(IV) and encapsulation with a red‐blood‐cell membrane, this nanocatalytic agent (Pt@IrSAC/RBC) causes intense lipid peroxidation that boosts tumor cell ferroptosis. The Pt@IrSAC/RBC demonstrates superior therapeutic efficacy in a mouse triple‐negative mammary carcinoma model, resulting in complete tumor ablation in a single treatment session with negligible side effects. These outcomes may provide valuable insights into the design of nanocatalysts with high performance and biosafety for biomedical applications.

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Protein encapsulation of nanocatalysts: A feasible approach to facilitate catalytic theranostics

Cited by 9 publications

References 233 publications

A Molecular Switch‐Integrated Nanoplatform Enables Photo‐Unlocked Antibacterial Drug Delivery for Synergistic Abscess Therapy

A Molecular Switch‐Integrated Nanoplatform Enables Photo‐Unlocked Antibacterial Drug Delivery for Synergistic Abscess Therapy

Engineering Single‐Atom Nanozymes for Catalytic Biomedical Applications

Boosting Ferroptosis Therapy with Iridium Single‐Atom Nanocatalyst in Ultralow Metal Content

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