Protein expression and promoter methylation of the candidate biomarker TCF21 in head and neck squamous cell carcinoma

Weiß, Daniel; Stockmann, Christian; Schrödter, Katrin; Rudack, Claudia

doi:10.1007/s13402-013-0129-5

Cited by 32 publications

(32 citation statements)

References 39 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Seventeen articles met the inclusion criteria and were eligible for further analysis. [28][29][30][31][32][33][34][35][36][37][38][39][40][41][42][43][44] The main reasons for exclusion were duplicates and studies not investigating correlation between HPV status and methylation status in OPSCC.…”

Section: Search Resultsmentioning

confidence: 99%

“…28,33,34,44 In other publications studying overall HNSCC, OPSCC subgroup size ranged from 9% to 80% of the total study population. [29][30][31][32][35][36][37][38][39][40][41][42][43] There was only one study that reported the distribution of average age, nicotine and alcohol consumption between HPV-positive and HPV-negative tumors of which promoter methylation was evaluated. 34 The mean age in HPV-positive tumors was 56.9 compared with 58.4 in HPV-negative tumors.…”

Section: Study Characteristicsmentioning

confidence: 99%

“…28,29,32,[34][35][36][37]40 Six used fresh frozen (FF) tissue or both. 31,38,[41][42][43][44] Three studies did not report used material. 30,33,39 The majority of studies used polymerase chain reaction (PCR) to detect HPV 16 DNA.…”

Section: Study Characteristicsmentioning

confidence: 99%

“…30,33,39 The majority of studies used polymerase chain reaction (PCR) to detect HPV 16 DNA. Three studies 34,41,43 used PCR and immunohistochemistry (IHC) and Poage et al used multiplex serology. 38 Sartor et al did not describe their method to detect HPV DNA.…”

Section: Study Characteristicsmentioning

confidence: 99%

“…33,42,44 Thirteen studies evaluated promoter methylation in selected genes in association with HPV status. [28][29][30][31][33][34][35][36][37][41][42][43][44] Three studies investigated global methylation in association with HPV status. 32,38,39 One study examined both promoter methylation and global methylation, in association with HPV status.…”

Section: Study Characteristicsmentioning

confidence: 99%

See 4 more Smart Citations

Differences in methylation profiles between HPV-positive and HPV-negative oropharynx squamous cell carcinoma

et al. 2013

View full text Add to dashboard Cite

Section: Search Resultsmentioning

confidence: 99%

Section: Study Characteristicsmentioning

confidence: 99%

Section: Study Characteristicsmentioning

confidence: 99%

Section: Study Characteristicsmentioning

confidence: 99%

Section: Study Characteristicsmentioning

confidence: 99%

See 3 more Smart Citations

Differences in methylation profiles between HPV-positive and HPV-negative oropharynx squamous cell carcinoma

et al. 2013

View full text Add to dashboard Cite

A systematic review of the HPV‐attributable fraction of oropharyngeal squamous cell carcinomas in Germany

et al. 2019

View full text Add to dashboard Cite

The prevalence of oropharyngeal squamous cell carcinoma (OPSCC) is increasing globally while the prevalence of other head and neck cancers is decreasing. The most likely reasons for this are a decreasing influence of smoking and the growing relevance of infections with the human papilloma virus (HPV) as a risk factor. A rise in the HPV‐attributable fraction (HPV‐AF) of OPSCC has been observed in many countries, yet a comprehensive review of prevalence rates and trends in Germany is lacking. To determine the current HPV‐AF of OPSCC in Germany and to assess whether it has changed during the last decades, we performed a systematic literature review. We screened Medline and EMBASE for studies that reported the tumor HPV status of newly diagnosed OPSCC patients treated at medical centers in Germany by testing for both HPV DNA and p16INK4a overexpression to confirm involvement of HPV in tumorigenesis. Out of 287 screened studies, 14 studies with data from a total of 1819 OPSCC patients treated between 1988 and 2015 were included in the data synthesis. The reported average HPV‐AF varied considerably between the studies, ranging from 11.5% (1988‐2008) to 55.0% (2004‐2009). Two of the included studies did not only provide the HPV‐AF for the entire observed calendar period but also for separate years, allowing to more accurately assess changes over time. These studies reported increases in the HPV‐AF from 21% in 2000 to 53% in 2015 and from 38% in 2004 to 71% in 2013, respectively.

show abstract

HPV‐positive oropharyngeal squamous cell carcinoma is associated with TIMP3 and CADM1 promoter hypermethylation

et al. 2014

View full text Add to dashboard Cite

Oropharyngeal squamous cell carcinoma (OPSCC) is associated with human papillomavirus (HPV) in a proportion of tumors. HPV-positive OPSCC is considered a distinct molecular entity with a prognostic advantage compared to HPV-negative cases. Silencing of cancer-related genes by DNA promoter hypermethylation may play an important role in the development of OPSCC. Hence, we examined promoter methylation status in 24 common tumor suppressor genes in a group of 200 OPSCCs to determine differentially methylated genes in HPV-positive versus HPV-negative primary OPSCC. Methylation status was correlated with HPV status, clinical features, and patient survival using multivariate methods. Additionally, methylation status of 16 cervical squamous cell carcinomas (SCC) was compared with HPV-positive OPSCC. Using methylation-specific probe amplification, HPV-positive OPSCC showed a significantly higher cumulative methylation index (CMI) compared to HPV-negative OPSCC (P=0.008). For the genes CDH13, DAPK1, and RARB, both HPV-positive and HPV-negative OPSCC showed promoter hypermethylation in at least 20% of the tumors. HPV status was found to be an independent predictor of promoter hypermethylation of CADM1 (P < 0.001), CHFR (P = 0.027), and TIMP3 (P < 0.001). CADM1 and CHFR showed similar methylation patterns in OPSCC and cervical SCC, but TIMP3 showed no methylation in cervical SCC in contrast to OPSCC. Methylation status of neither individual gene nor CMI was associated with survival. These results suggest that HPV-positive tumors are to a greater extent driven by promotor hypermethylation in these tumor suppressor genes. Especially CADM1 and TIMP3 are significantly more frequently hypermethylated in HPV-positive OPSCC and CHFR in HPV-negative tumors.

show abstract

Protein expression and promoter methylation of the candidate biomarker TCF21 in head and neck squamous cell carcinoma

Cited by 32 publications

References 39 publications

Differences in methylation profiles between HPV-positive and HPV-negative oropharynx squamous cell carcinoma

Differences in methylation profiles between HPV-positive and HPV-negative oropharynx squamous cell carcinoma

A systematic review of the HPV‐attributable fraction of oropharyngeal squamous cell carcinomas in Germany

HPV‐positive oropharyngeal squamous cell carcinoma is associated with TIMP3 and CADM1 promoter hypermethylation

Contact Info

Product

Resources

About