2009
DOI: 10.1074/mcp.m800323-mcp200
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Protein Expression Profiling in the African Clawed Frog Xenopus laevis Tadpoles Exposed to the Polychlorinated Biphenyl Mixture Aroclor 1254

Abstract: Exposure to environmental pollutants such as polychlorinated biphenyls (PCBs) is now taken into account to partly explain the worldwide decline of amphibians. PCBs induce deleterious effects on developing amphibians including deformities and delays in metamorphosis. However, the molecular mechanisms by which they express their toxicity during the development of tadpoles are still largely unknown. A proteomics analysis was performed on developing Xenopus laevis tadpoles exposed from 2 to 5 days postfertilizatio… Show more

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Cited by 44 publications
(22 citation statements)
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References 87 publications
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“…Longer studies involving chronic exposure to chemicals until metamorphosis (Newman et al 2006;Relyea and Hoverman 2006), post-exposure tests at the larval stage (Berrill et al 1998;Jones et al 2009) but also through the entire life cycle (Hayes et al 2010;Kvarnryd et al 2011) allowed researchers to examine the effects of pollutants at low concentrations on the long term. Both short and long term studies provided fine scale data such as gene or protein signature (Gillardin et al 2009a), cytology (Marquis et al 2010), physiology (Gillardin et al 2009b), morphology (Bernabò et al 2008), and behavior (Bromhall 2005;Giusi et al 2010;Egea-Serrano et al 2011). Both short and longterm methods are complementary, but it would be useful to develop more sublethal markers for short-term tests.…”
Section: Introductionmentioning
confidence: 98%
“…Longer studies involving chronic exposure to chemicals until metamorphosis (Newman et al 2006;Relyea and Hoverman 2006), post-exposure tests at the larval stage (Berrill et al 1998;Jones et al 2009) but also through the entire life cycle (Hayes et al 2010;Kvarnryd et al 2011) allowed researchers to examine the effects of pollutants at low concentrations on the long term. Both short and long term studies provided fine scale data such as gene or protein signature (Gillardin et al 2009a), cytology (Marquis et al 2010), physiology (Gillardin et al 2009b), morphology (Bernabò et al 2008), and behavior (Bromhall 2005;Giusi et al 2010;Egea-Serrano et al 2011). Both short and longterm methods are complementary, but it would be useful to develop more sublethal markers for short-term tests.…”
Section: Introductionmentioning
confidence: 98%
“…Proteins are the actual functional molecules in the cell and therefore, proteomic analysis may provide more direct insight into the mechanisms of the MP effects [19,20]. The use of the proteomics technique in vertebrate ecotoxicology has increased greatly in recent years, for example in rat [21,22], frog [23], and fish [24]. Recently, environmental proteomics has also been applied to marine organisms at the laboratory and field level, such as sheepshead minnows [25] and mussel [26].…”
Section: Introductionmentioning
confidence: 99%
“…ER stress is also induced by high levels of misfolded proteins accumulation, which generates the unfolded protein response. The unfolded protein response results in the regulation of chaperones such as GRP58 and PDI to prevent protein aggregation and cell death (28,29), which has been proved by many previous studies (30 -32). In the present study, the inhibition of PDIA3 expression in all VRPtreated groups shows that the ER stress is present in fish hepatic cells.…”
Section: Discussionmentioning
confidence: 93%