Protein Factor of Fertility in Malignancies

Yus, T. M.; Shcherbakova, L A; Olefirenko, G. A.; Петрунин, Д. Д.

doi:10.1159/000217645

Cited by 9 publications

(4 citation statements)

References 7 publications

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“…Glycodelin is found in a number of cancers, such as ovarian (Kämäräinen et al, 1996) and uterine tumors (Tatarinov et al, 1990), synovial sarcomas (Kämäräinen Fig. 3.…”

Section: Discussionmentioning

confidence: 99%

Stimulation of lipocalin‐type prostaglandin D synthase by retinoic acid coincides with inhibition of cell proliferation in human 3AO ovarian cancer cells

Guan

Xia

et al. 2003

Cell Biology International

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Lipocalin-type prostaglandin D synthase (LPGDS; PGH(2)D-isomerase; EC 5.3.99.2) is a bifunctional protein first identified in the mammalian brain. It acts as a PGD(2)-producing enzyme and a retinoid transporter. Recent studies have shown that LPGDS is anomalously expressed in ovarian tumors and that retinoid may have a role as an ovarian cancer chemotherapeutic agent. To determine whether there is a relationship between retinoid and LPGDS in ovarian tumors, we examined the regulation of the gene encoding LPGDS by all-trans retinoic acid (RA). Real-time quantitative RT-PCR analysis showed that RA strongly induced the accumulation of LPGDS mRNA in human 3AO ovarian cancer cells. Furthermore, treatment of the cells with RA induced the synthesis and secretion of LPGDS into the culture medium. This increased expression of LPGDS was accompanied by an inhibition of cell proliferation in the ovarian cancer cells. Prostaglandin D synthase, ovarian cancer, retinoic acid, real-time quantitative RT-PCR.

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“…Glycodelin is found in a number of cancers, such as ovarian (Kämäräinen et al, 1996) and uterine tumors (Tatarinov et al, 1990), synovial sarcomas (Kämäräinen Fig. 3.…”

Section: Discussionmentioning

confidence: 99%

Stimulation of lipocalin‐type prostaglandin D synthase by retinoic acid coincides with inhibition of cell proliferation in human 3AO ovarian cancer cells

Guan

Xia

et al. 2003

Cell Biology International

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“…Elevated levels of PAMG-2 were demonstrated in serum of patients with ovarian and uterine malignancies [19,68,69]. Ovarian tumors also contain splicing variants of the mRNA [21].…”

Section: Tumorsmentioning

confidence: 99%

“…By contrast, in keeping with the immunochemical detection of CAG-2, · 2 -PEG, PP14 and PEP from secretory and decidualized endometrium [10][11][12][13][14] these tissues were found to fulfill both these criteria of transcription and translation [7,9,15] signifying that PP14 is an endometrial protein. However, PP14 is not restricted to endometrium, as both its mRNA and the protein have been found in many tissues including the fallopian tube [15,16], bone marrow [17], ovarian tumors and normal ovary [18][19][20][21], breast and breast cancer, pancreatic cystadenoma, hidradenoma, and parabronchial and sweat glands [22]. On the basis of these studies, it is obvious that none of the previous names accurately reflects the site of synthesis, characteristics or function and, therefore, the name glycodelin was introduced to indicate the key role of glycosylation for its functions.…”

mentioning

confidence: 99%

Glycodelins

Seppälä¹,

Bohn²,

Tatarinov³

1998

Tumor Biol

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Glycodelins are 28 to 30-kD glycoproteins synthesized in various glands, notably those of the male and female reproductive organs. Depending on the site of origin, the same protein backbone is glycosylated in different ways, yielding glycodelins with different biological actions. Thus, human endometrium-derived glycodelin-A is temporally expressed in the latter half of the menstrual cycle, consists of unique sialylated and fucosylated lacdiNAc oligosaccharide sequences, and inhibits sperm-egg binding. By contrast, glycodelin-S from seminal vesicles has no such oligosaccharide sequences and no contraceptive activity. Glycodelin-A also has potent immunosuppressive properties, and its chemically modified forms inhibit transmission of HIV in vitro. Studies are reviewed suggesting that glycoforms dictate the function of human glycodelins, and that some of the oligosaccharide recognition sites present in the human gametes and immune cells have converged.

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“…In 1987, the new terminology and abbreviation for CAG-2 as the protein factor of fertility (PFF) [16] was suggested, although this term is no better than others.…”

Section: Introductionmentioning

confidence: 99%

Human Protein Factor of Fertility and Spontaneous Abortion

Tatarinov

Posiseeva

Belyankin

1993

Gynecol Obstet Invest

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The concentration of human protein factor of fertility (PFF) in seminal plasma was measured by a semi-quantitative immunodiffusion method with the standard test system. Fresh seminal plasma from 202 men with normal fertility was investigated. The levels of PFF ranged from 2 to 512 mg/l in normospermic specimens. The retrospective analysis revealed a positive correlation (p < 0.001) between low PFF concentration (2–8 mg/l) in the husband’s seminal plasma and primary early spontaneous abortion in the wife.

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Protein Factor of Fertility in Malignancies

Cited by 9 publications

References 7 publications

Stimulation of lipocalin‐type prostaglandin D synthase by retinoic acid coincides with inhibition of cell proliferation in human 3AO ovarian cancer cells

Stimulation of lipocalin‐type prostaglandin D synthase by retinoic acid coincides with inhibition of cell proliferation in human 3AO ovarian cancer cells

Glycodelins

Human Protein Factor of Fertility and Spontaneous Abortion

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