Protein fractionation of pH‐responsive brush‐modified ethylene vinyl alcohol copolymer membranes*

Ye, Hui; Zhou, Yining; Yang, Guodong; Yu, Tingting; Zhang, Yuzhong; Zhao, Lizhi; Xin, Qingping; Han, Shurui

doi:10.1002/pen.25904

Cited by 5 publications

(3 citation statements)

References 32 publications

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“…Polymer brushes are considered to be promising systems for the creation of such coatings. Being able to improve product performance and reduce maintenance expenses [ 1 ], smart polymer coatings (SPC) can be exploited in a variety of industrial sectors, providing a wide range of applications such as switch sensors [ 2 , 3 , 4 ], antifouling surfaces [ 5 , 6 , 7 , 8 ], lubrication [ 9 ], targeting drug delivery [ 10 , 11 , 12 , 13 , 14 , 15 ], and chromatographic protein separations [ 16 , 17 , 18 ].…”

Section: Introductionmentioning

confidence: 99%

Chains Stiffness Effect on the Vertical Segregation of Mixed Polymer Brushes in Selective Solvent

et al. 2023

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The microstructure of the binary polymer brushes in the selective solvent was studied using the numerical lattice self-consisting field approach. The case was considered when the selectivity to the solvent (the Flory–Huggins parameter χ) was varied only for one type of chains (responsive chains) while the others (non-responsive chains) remained hydrophilic (χ = 0). In such a brush, with an increase in the hydrophobicity of the responsive chains, a transition occurs between two two-layer microstructures. In the initial state the ends of the longer responsive chains are located near the external surface of the brush and those of non-responsive chains are inside the brush. When the hydrophobicity of the responsive chains becomes high enough then the reversed two-layer microstructure is formed, when the ends of non-responsive chains are located near the brush surface and the responsive chains collapse on the brush bottom. In contrast to previous works, the stiffness parameter (Kuhn segment length p) for one or for both types of chains was varied and its effect on the mechanism and characteristics of the transition was studied. If the stiffness of only responsive chains increases, then the transition occurs with the formation of an intermediate three-layer microstructure, where a layer of responsive chains is located between layers formed by non-responsive ones. If both types of chains have the same p, then the transition occurs gradually without the formation of an intermediate three-layer microstructure. For both cases, the effect of p on the critical value of χ*, corresponding to the transition point and on the steepness of the transition was investigated.

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Section: Introductionmentioning

confidence: 99%

Chains Stiffness Effect on the Vertical Segregation of Mixed Polymer Brushes in Selective Solvent

et al. 2023

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“…Polymer brushes, which are formed by grafting polymer chains on a surface, provide a convenient method for the modification of surface properties. − In particular, multicomponent brushes, composed of chemically different brushes which respond to external stimuli, such as environmental temperature, pH, and electric or magnetic fields, could be exploited for the design of smart materials with a wide range of applications in nano- and biotechnology, − for example, switch sensors, − antifouling surfaces, − targeting drug delivery, ,− and chromatographic protein separations. − Two basic quantities that determine the performance of these smart materials are the material sensitivity and response time. For practical uses, people normally pursue smart materials with high sensitivity and a short response time.…”

Section: Introductionmentioning

confidence: 99%

Size Effect of the End-Attached Particle on the Adsorption-Responsive Polymer Switches

Lian

2022

Macromolecules

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Using analytical theory and self-consistent field calculations, we study the conformation behaviors and switching properties of an adsorption-active polymer chain with its free end attached to a hard-core nanoparticle included in an inert brush. The conformation switches are induced by the short-ranged adsorption from the substrate. Particularly, we focus on the influence of particle size and quantify the switching properties by evaluating the transition point, transition width, and transition barrier. Our results indicate that the particle–polymer system exhibits different phases and transition features compared to the particle-free system only when the particle is large enough. To characterize the particle size, we define two critical particle radii R* and R c. If R > R*, the particle could be stuck at the brush surface exhibiting a partially exposed state, which cannot be observed in the particle-free polymer switches. On the contrary, if the particle is small, only two states, the exposed state and the adsorbed state, are involved. When R > R c, the transition properties show different dependence on the system parameters like the grafting density of the brush, the solvent quality, and the length of the polymer chains. Analytical expressions for the transition point, transition width, and transition barrier are derived. The obtained scaling formulas at the small particle and large particle limits are verified by the self-consistent field calculations. Our analysis concludes that a large particle attached to the end of the active chain mainly broadens the transition width while keeps the transition barrier as small as that in the free-particle system as the system parameters are carefully tuned. Strong osmotic repulsion imposed on the finite volume particle is responsible for the particular phase and transition characteristics observed in the present particle–polymer switches.

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“…Stimuli-responsive polymers are often immobilized as "polymer brushes" on substrate surfaces, which can be solid [23,24], colloidal [25], or polymeric membrane surfaces [26], by either physical adsorption or chemical bonding. Physical adsorption is relatively simple to operate, but the coatings fabricated via this method are prone to failure due to the lack of a strong interaction between the substrate surfaces and the coatings [27,28].…”

Section: Introductionmentioning

confidence: 99%

A Multiple-Stimuli-Responsive Amphiphilic Copolymer for Antifouling and Antibacterial Functionality via a “Resistance–Kill–Release” Mechanism

Liao¹,

Niu²,

Liu³

et al. 2022

Molecules

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In recent years, polymers with stimuli-responsive properties have been increasingly reported on due to their diverse applications. However, most of the studies have only focused on the performance of polymers under specific scenarios. The laws of changes in the properties in response to various external stimuli have been less systematically and quantitatively studied. In this paper, we prepared an amphiphilic polymer (PadaMX and PAdaM3QA−X) with temperature-, pH-, ion-, and β-cyclodextrin (β-CD)-responsive properties. According to the cloud point tested by the UV-Vis method, the lower critical soluble temperature (LCST) of PAdaM3QA−10% was more sensitive to a change in pH and less sensitive to a change in ions compared with PadaM3 due to quaternized side chains with a stronger intramolecular mutual repulsion. We then fabricated the coatings with responsive properties by immobilizing the adamantyl groups on β-CD-modified surfaces. The hydrophilicity of the coatings was improved after quaternization, as proven by the water contact angle (WCA) measurement. The antifouling and antibacterial performance was further evaluated via the fluorescence intensity of bovine serum albumin (BSA) adsorbed on the surfaces and the spread plate method. A 78.4% BSA desorption rate and a 96.8% sterilization rate were achieved by the PAdaM3QA−10% coating. In summary, this work prepared a multiple-stimuli-responsive amphiphilic copolymer for antifouling and antibacterial functionality via a “resistance–kill–release” mechanism.

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Protein fractionation of pH‐responsive brush‐modified ethylene vinyl alcohol copolymer membranes*

Cited by 5 publications

References 32 publications

Chains Stiffness Effect on the Vertical Segregation of Mixed Polymer Brushes in Selective Solvent

Chains Stiffness Effect on the Vertical Segregation of Mixed Polymer Brushes in Selective Solvent

Size Effect of the End-Attached Particle on the Adsorption-Responsive Polymer Switches

A Multiple-Stimuli-Responsive Amphiphilic Copolymer for Antifouling and Antibacterial Functionality via a “Resistance–Kill–Release” Mechanism

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