Protein Glycation During Diabetes Mellitus and the Possibility of its Pharmacological Correction (Review)

Spasov, A. A.; Соловьева, Ольга Александровна; Кузнецова, В. А.

doi:10.1007/s11094-017-1627-y

Cited by 5 publications

(4 citation statements)

References 39 publications

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“…One of the complications of chronic hyperglycemia state is the glycosylation of various molecules such as proteins, and the formation of AGEs. Following the increase in AGEs concentration and binding to their receptors (RAGE), the membrane of the glomerular vasculature is thinned and causes fibrosis (33). As declared in previous studies, Pioglitazone is an effective agent for the treatment of diabetes in this population, as evidenced by improvement in HgbA1c levels (34)(35)(36).…”

Section: Discussionmentioning

confidence: 88%

A Triple-Blind Randomized Controlled Trial on Impacts of Pioglitazone on Oxidative Stress Markers in Diabetic Kidney Transplant Recipients

et al. 2020

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Background: Oxidative stress as a major mediator of adverse outcomes in kidney transplant recipients who are prone to oxidative stress-mediated injury by pre-transplant and post-transplant conditions. Objectives: The purpose of this study was to assess the effects of Pioglitazone on oxidative stress biomarkers and blood glucose control in diabetic patients receiving insulin after kidney transplantation. Methods: In a triple-blind randomized placebo-controlled trial, sixty-two kidney transplanted diabetic patients (40 men and 24 women) were followed for 4 months after randomly assigned to the placebo group and Pioglitazone group (30 mg/d). All of the patients continued their insulin therapy irrespective of the group that they were assigned to evaluate the effects of the addition of pioglitazone on blood glucose and oxidative stress biomarkers, Malondialdehyde (MDA) and total protein carbonyls (TPC) serum levels. Results: At baseline, there were no statistically signiﬁcant differences in glycemic control levels and oxidative markers between the two groups. After 4 months of intervention, a significant improvement occurred in HBA1c in the Pioglitazone group. The changes of Hemoglobin A1c (HBA1c) during 4 months of follow up in the Pioglitazone group show improvement in glucose control were as HBA1c in the placebo group increased by 0.3% (P = 0.0001). Moreover, at the end of the study, the MDA level was significantly lower in the Pioglitazone group (P < 0.0001, 1.22 - 3.90). Regarding the serum level of TPC, the changes were not statistically different at baseline and also at the end of the study between two groups. Conclusions: Administration of Pioglitazone in addition to insulin in diabetic kidney transplant patients not only improved glycemic control (evidenced by HBA1c) but also significantly decreased oxidative stress markers such as MDA.

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Section: Discussionmentioning

confidence: 88%

A Triple-Blind Randomized Controlled Trial on Impacts of Pioglitazone on Oxidative Stress Markers in Diabetic Kidney Transplant Recipients

et al. 2020

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“…Diabetics have impaired sugar metabolism and insulin deficiency and/or decreased cellular sensitivity to insulin. Long-term hyperglycemia causes an increase in metabolic disorders and biochemical abnormalities; it results in increased protein glycation and accelerated development of complications: micro-and macroangiopathies [2][3][4]. The Maillard reaction is a biochemical transformation leading to non-enzymatic protein glycation and, consequently, to the loss or modification of their original role when occurring in the body [5][6][7].…”

Section: Introductionmentioning

confidence: 99%

Antiglycoxidative Properties of Extracts and Fractions from Reynoutria Rhizomes

2021

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Hyperglycemia, when sustained over a long time in diabetes mellitus (DM), leads to biochemical and cellular abnormalities, primarily through the formation of advanced glycation end-products (AGEs). In the treatment of diabetes, beside blood-sugar-lowering medications, a consumption of herbal products that can inhibit the AGEs’ formation is recommended. This study investigated the in vitro antiglycoxidative potential of extracts and fractions from the rhizomes of Japanese, Giant, and Bohemian knotweeds (Reynoutria japonica (Houtt.), R. sachalinensis (F. Schmidt) Nakai, and R.× bohemica Chrtek et Chrtkova). Their effects on glycooxidation of bovine and human serum albumin were evaluated by incubation of the proteins with a mixture of glucose and fructose (0.5 M) and 150 µg/mL of extract for 28 days at 37 °C, followed by measuring early and late glycation products, albumin oxidation (carbonyl and free thiol groups), and amyloid-β aggregation (thioflavin T and Congo red assays). The highest antiglycoxidative activity, comparable or stronger than the reference drug (aminoguanidine), was observed for ethyl acetate and diethyl ether fractions, enriched in polyphenols (stilbenes, phenylpropanoid disaccharide esters, and free and oligomeric flavan-3-ols). In conclusion, the antiglycoxidative compounds from these three species should be further studied for potential use in the prevention and complementary treatment of DM.

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“…A major problem faced by diabetic people is the development of microvascular (nephropathy, neuropathy, and retinopathy) and macrovascular complications (cardio vascular disease, and cerebrovascular disease) reducing their quality of life greatly [12]. Persistent hyperglycemia leading to the formation of advanced glycated end products (AGEs) is implicated in the development of diabetic complications [13]. Food-derived antioxidants and AGE inhibitors are considered safe and suitable for managing diabetic complications.…”

Section: Introductionmentioning

confidence: 99%

Multi-Mechanistic In Vitro Evaluation of Antihyperglycemic, Antioxidant and Antiglycation Activities of Three Phenolic-Rich Indian Red Rice Genotypes and In Silico Evaluation of Their Phenolic Metabolites

Haldipur

Srividya

2021

Foods

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The study evaluated the antidiabetic potential of three traditional Indian red rice genotypes/RR (Kattuyanam/KA, Chennangi/CH & Karungkuruvai/KU) using a combination of in vitro, metabolomics (Quadrupole-Time of Flight-Liquid chromatography-Mass spectrometry/Q-TOF-LC-MS/MS), and in silico techniques. In terms of antihyperglycemic potential, KA exhibited the highest inhibitory activity against α-amylase; CH against α-glucosidase; and KU against DPPIV and PTP1B enzymes. KA exhibited the highest antioxidant activity (DPPH, FRAP, and ABTS) and greater inhibition of protein glycation compared to other RR indicating its potential to mitigate diabetic complications. The metabolomic analysis confirmed the presence of 99 phenolics in the sample extracts (KU-71, KA-70, CH-68). Molecular docking studies revealed seven metabolites to be good inhibitors of the four target enzymes and activators of insulin receptor substrate/IRS. The antihyperglycemic and oxidation-glycation reduction composite index revealed KA to have the highest overall antidiabetic potential. Hence, the RR could be utilized in functional foods with a multi-barrelled strategy for diabetes prevention/management.

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Protein Glycation During Diabetes Mellitus and the Possibility of its Pharmacological Correction (Review)

Cited by 5 publications

References 39 publications

A Triple-Blind Randomized Controlled Trial on Impacts of Pioglitazone on Oxidative Stress Markers in Diabetic Kidney Transplant Recipients

A Triple-Blind Randomized Controlled Trial on Impacts of Pioglitazone on Oxidative Stress Markers in Diabetic Kidney Transplant Recipients

Antiglycoxidative Properties of Extracts and Fractions from Reynoutria Rhizomes

Multi-Mechanistic In Vitro Evaluation of Antihyperglycemic, Antioxidant and Antiglycation Activities of Three Phenolic-Rich Indian Red Rice Genotypes and In Silico Evaluation of Their Phenolic Metabolites

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