Protein hydrolysates from β‐conglycinin enriched soybean genotypes inhibit lipid accumulation and inflammation <i>in vitro</i>

Martínez‐Villaluenga, Cristina; Dia, Vermont P.; Berhow, Mark A.; Bringe, Neal A.; Mejía, Elvira González de

doi:10.1002/mnfr.200800473

Cited by 78 publications

(43 citation statements)

References 56 publications

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“…Some isoflavones are potent dual PPARα/γ agonists and/or aryl hydrocarbon receptor (AhR) agonists and induce cell cycle arrest and modulate xenobiotic metabolism (Medjakovic et al 2010). Moreover, soy protein hydrolysates can decrease expression of inflammatory genes in vitro (Martinez-Villaluenga et al 2009) and, more importantly have potential clinical applications, in vivo (Nagarajan et al 2008). Further therapeutic potential is present in soy-derived di-and tripeptides which have shown recent promise in alleviating colon and ileum inflammation, in vivo (Young et al 2012).…”

Section: Traditional Medical Uses For Sweet Potato For a Modern Agementioning

confidence: 99%

Healthy aging diets other than the Mediterranean: A focus on the Okinawan diet

Willcox

Scapagnini

Willcox

2014

Mechanisms of Ageing and Development

208

121

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The traditional diet in Okinawa is anchored by root vegetables (principally sweet potatoes), green and yellow vegetables, soybean-based foods, and medicinal plants. Marine foods, lean meats, fruit, medicinal garnishes and spices, tea, alcohol are also moderately consumed. Many characteristics of the traditional Okinawan diet are shared with other healthy dietary patterns, including the traditional Mediterranean diet, DASH diet, and Portfolio diet. All these dietary patterns are associated with reduced risk for cardiovascular disease, among other age-associated diseases. Overall, the important shared features of these healthy dietary patterns include: high intake of unrefined carbohydrates, moderate protein intake with emphasis on vegetables/legumes, fish, and lean meats as sources, and a healthy fat profile (higher in mono/polyunsaturated fats, lower in saturated fat; rich in omega-3). The healthy fat intake is likely one mechanism for reducing inflammation, optimizing cholesterol, and other risk factors. Additionally, the lower caloric density of plant-rich diets results in lower caloric intake with concomitant high intake of phytonutrients and antioxidants. Other shared features include low glycemic load, less inflammation and oxidative stress, and potential modulation of aging-related biological pathways. This may reduce risk for chronic age-associated diseases and promote healthy aging and longevity.

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Section: Traditional Medical Uses For Sweet Potato For a Modern Agementioning

confidence: 99%

Healthy aging diets other than the Mediterranean: A focus on the Okinawan diet

Willcox

Scapagnini

Willcox

2014

Mechanisms of Ageing and Development

208

121

View full text Add to dashboard Cite

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“…Soy phytochemicals such as isoflavones (11,12) and saponins (13) and proteins, including Bowman-Birk trypsin inhibitors (14) and lunasin (15), have been reported to reduce inflammation. Recently, soy protein hydrolysates were shown to reduce the expression of inflammatory genes in vitro (16) and in vivo (17). Although antiinflammatory soy di-or tripeptides have not yet been reported, to our knowledge, past studies of bioactive soy peptides (18,19) suggest that with the aid of peptide transporter 1 and paracellular intestinal transport (20), these peptides can cross the intestinal barrier, arrive in an intact form, and exert bioactivity at the target site.…”

Section: Introductionmentioning

confidence: 96%

Soy-Derived Di- and Tripeptides Alleviate Colon and Ileum Inflammation in Pigs with Dextran Sodium Sulfate-Induced Colitis3

Young

Ibuki

Nakamori

et al. 2012

The Journal of Nutrition

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We evaluated the antiinflammatory activity of soy-derived di- and tripeptides in a dextran sodium sulfate (DSS)-induced pig model of intestinal inflammation. In the DSS-positive control (POS) and DSS-positive with soy peptide treatment (SOY) groups (n = 6/group), DSS was administered to piglets via i.g. catheter for 5 d, followed by a 5-d administration of saline or soy-derived peptides, respectively. A negative control (NEG) group received saline in lieu of the DSS and soy peptides. The severity of inflammation was assessed by clinical signs, morphological and histological measurements, gut permeability, and neutrophil infiltration. Local production of TNF and IL6 were measured by ELISA, colonic and ileal inflammatory gene expression were assessed by real-time RT-PCR, and CD4+CD25+ lymphocyte populations were analyzed by flow cytometry. Crypt elongation and muscle thickness, d-mannitol gut permeation, colonic expression of the inflammatory mediators IFNG, IL1B, TNF, RORC, and IL17A as well as the FOXP3 T-regulatory transcription factor, and myeloperoxidase activity were lower (P < 0.05) in the SOY pigs than in POS pigs. Messenger RNA levels of ileal IFNG, TNF, IL12B, and IL17A were lower (P < 0.05) and FOXP3 expression was greater (P < 0.05) in SOY piglets than in the POS group. In the mesenteric lymph nodes, CD4+CD25+ T cells were higher (P < 0.05) in both the POS and SOY groups than in NEG controls. Soy-derived peptides exert antiinflammatory activity in vivo, suggesting their usefulness for the treatment of inflammatory disorders.

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“…A dietary study performed using a β-conglycinin enriched genotype of soybean has suggested the importance of this protein for hypocholesterolaemic activity (Martinez-Villaluenga, Dia, Berhow, Bringe, & de Mejia, 2009). Some investigations have shown that its α′ subunit may have a major role in the cholesterol-lowering properties of soybean (Consonni et al, 2010(Consonni et al, , 2011Duranti et al, 2004).…”

Section: Introductionmentioning

confidence: 98%