Protein intake and kidney function in the middle-age population: contrast between cross-sectional and longitudinal data

Cirillo, Massimo; Lombardi, Cinzia; Chiricone, Daniela; Santo, Natale G. De; Zanchetti, Alberto; Bilancio, Giancarlo

doi:10.1093/ndt/gfu056

Cited by 67 publications

(65 citation statements)

References 27 publications

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“…16 The quoted experimental findings are strongly supported by a recently published Italian 12-year observational study of 1,144 middle-aged adults. 17 In that study, Cirillo et al demonstrated a highly significant positive correlation between protein intake and estimated GFR (eGFR) at baseline, but also a highly significant inverse relationship between baseline protein intake and the 12-year decline in eGFR. Two other large observational studies were unable to identify any effect of protein intake on baseline and subsequent eGFR changes in healthy adults, however.…”

Section: Hyperfiltration and Renal Damagementioning

confidence: 94%

High-Protein Diets and Renal Health

Marckmann

Osther

Pedersen

et al. 2015

Journal of Renal Nutrition

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Section: Hyperfiltration and Renal Damagementioning

confidence: 94%

High-Protein Diets and Renal Health

Marckmann

Osther

Pedersen

et al. 2015

Journal of Renal Nutrition

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“…There are additional studies with conflicting results for the impact of high protein diet on renal function decline in the general population. [12,13]…”

Section: Impact Of High Protein Diet On Renal Functionmentioning

confidence: 99%

Dietary protein intake and chronic kidney disease

Ko¹,

Obi

Tortorici

et al. 2017

Current Opinion in Clinical Nutrition &Amp; Metabolic Care

203

132

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Purpose of review High protein intake may lead to increased intraglomerular pressure and glomerular hyperfiltration. This can cause damage to glomerular structure leading to or aggravating chronic kidney disease (CKD). Hence, a low protein diet (LPD) of 0.6–0.8 g/kg/day is often recommended for the management of CKD. We reviewed the effect of protein intake on incidence and progression of CKD and the role of LPD the CKD management. Recent findings Actual dietary protein consumption in CKD patients remain substantially higher than the recommendations for LPD. Notwithstanding the inconclusive results of the Modification of Diet in Renal Disease (MDRD) study, the largest randomized controlled trial to examine protein restriction in CKD, several prior and subsequent studies and meta-analyses including secondary analyses of the MDRD data appear to support the role of LPD on retarding progression of CKD and delaying initiation of maintenance dialysis therapy. LPD can also be used to control metabolic derangements in CKD. Supplemented LPD with essential amino acids or their keto-analogs may be used for incremental transition to dialysis especially in non-dialysis days. An LPD management in lieu of dialysis therapy can reduce costs, enhance psychological adaptation, and preserve residual renal function upon transition to dialysis. Adherence and adequate protein and energy intake should be ensured to avoid protein-energy wasting. Summary A balanced and individualized dietary approach based on LPD should be elaborated with periodic dietitian counselling and surveillance to optimize management of CKD, to assure adequate protein and energy intake and to avoid or correct protein-energy wasting.

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“…The relationship between dietary protein and DKD is less definitive with regard to the effects of the amount and source of protein on kidney outcomes, and specifically on preventing and impeding the progression of DKD. It is well accepted that excessive dietary protein intake is associated with a worsening of kidney function, increased albuminuria, and CVD mortality ( 10 – 14 ).…”

Section: Dietary Protein and Dkdmentioning

confidence: 99%

Nutrition Intervention for Advanced Stages of Diabetic Kidney Disease

Goldstein-Fuchs

Kalantar-Zadeh

2015

Diabetes Spectrum

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IN BRIEF For the goals of reducing diabetic kidney disease (DKD) onset and progression, approaches to nutritional therapy are a subject of much debate. This article discusses selected nutrients that have a role in affecting DKD outcomes and introduces application of newer, individualized concepts for healthful eating, as supported by clinical evidence relevant to patients with DKD. Selected aspects of management of advanced DKD are also reviewed.

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Protein intake and kidney function in the middle-age population: contrast between cross-sectional and longitudinal data

Abstract: In middle-aged adults, high protein intake is associated cross-sectionally with higher GFR but longitudinally with greater GFR decline over time.

Cited by 67 publications

References 27 publications

High-Protein Diets and Renal Health

High-Protein Diets and Renal Health

Dietary protein intake and chronic kidney disease

Nutrition Intervention for Advanced Stages of Diabetic Kidney Disease

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